Detailed information of TA system TA207619

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): higBA (relBE)/HigB-HigA
• Location: 4542189..4542943
• Replicon: chromosome
• Accession: NZ_CP077706
• Organism: Salmonella enterica subsp. enterica strain CFSAN058545

Toxin (Protein)

• Gene name: higB
• Uniprot ID: B5F003
• Locus tag: DAX52_RS21905
• Protein ID: WP_000558166.1
• Coordinates: 4542189..4542500 (+)
• Length: 104 a.a.

Antitoxin (Protein)

• Gene name: higA
• Uniprot ID: -
• Locus tag: DAX52_RS21910
• Protein ID: WP_001259011.1
• Coordinates: 4542497..4542943 (+)
• Length: 149 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
DAX52_RS21875 (4537847)	4537847..4538749	+	903	WP_000331361.1	formate dehydrogenase subunit beta	-
DAX52_RS21880 (4538746)	4538746..4539381	+	636	WP_000829025.1	formate dehydrogenase cytochrome b556 subunit	-
DAX52_RS21885 (4539378)	4539378..4540307	+	930	WP_070794361.1	formate dehydrogenase accessory protein FdhE	-
DAX52_RS21890 (4540354)	4540354..4540644	-	291	WP_000362050.1	DNA-binding transcriptional regulator	-
DAX52_RS21895 (4540645)	4540645..4540956	-	312	WP_001159631.1	cytotoxic translational repressor of toxin-antitoxin stability system	-
DAX52_RS21900 (4541174)	4541174..4542103	+	930	WP_001646963.1	alpha/beta hydrolase	-
DAX52_RS21905 (4542189)	4542189..4542500	+	312	WP_000558166.1	type II toxin-antitoxin system HigB family toxin	Toxin
DAX52_RS21910 (4542497)	4542497..4542943	+	447	WP_001259011.1	type II toxin-antitoxin system HigA family antitoxin	Antitoxin
DAX52_RS21915 (4542958)	4542958..4543899	-	942	WP_001518251.1	fatty acid biosynthesis protein FabY	-
DAX52_RS21920 (4543944)	4543944..4544381	-	438	WP_000560969.1	D-aminoacyl-tRNA deacylase	-
DAX52_RS21925 (4544378)	4544378..4545250	-	873	WP_000921423.1	virulence factor BrkB family protein	-
DAX52_RS21930 (4545244)	4545244..4545843	-	600	WP_001646959.1	glucose-1-phosphatase	-
DAX52_RS21935 (4546034)	4546034..4546837	-	804	WP_023137059.1	DeoR/GlpR family DNA-binding transcription regulator	-
DAX52_RS21940 (4546871)	4546871..4547767	-	897	WP_001520529.1	sugar kinase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, mRNA interferase HigB (21-93)

Antitoxin

• Cro/C1-type helix-turn-helix domain (93-146)

Sequences

Toxin

Protein

• Length: 104 a.a.
• Molecular weight: 12432.40 Da
• Isoelectric Point: 9.5334

>T207619 WP_000558166.1 NZ_CP077706:4542189-4542500 [Salmonella enterica subsp. enterica]
VHVISRKPFNEAMLMYPNHELALTELLNVLEKKTFTQPEEMKRYIPSLDNFKYRDKWWVIDVSGNSLRLISYIDFRLHKI
FVKHIVSHAEYDKLTAYYRGNKE

Nucleotide

• Length: 312 bp

>T207619 NZ_CP103446:c19790-19503 [Erwinia pyrifoliae]
ATGACTTATAAACTCAAGTTTGTCCCTTCCGCAGAGAAGGAATGGAAAAGGCTCGGGCACCCTGTCAGGGAGCAGTTCAA
AAAAAAGCTTGCTGAACGCCTGGAAAACCCCCGAGTGCCTTCAGCACAGCTTCATGGTCGTAAAGATCAGTACAAAATTA
AGCTAAAGTCTGCCGGTTACAGGCTGGTTTATCTGGTCCAGGAGCACACCATTACGATAATGGTTATGGGCATTGGCAAA
CGTGAAGGTAATCAGATTTACTCTGATACAGAGAACCGGCTTCCCTGA

Antitoxin

Protein

• Length: 149 a.a.
• Molecular weight: 16734.08 Da
• Isoelectric Point: 6.6451

>AT207619 WP_001259011.1 NZ_CP077706:4542497-4542943 [Salmonella enterica subsp. enterica]
MRTHRQMDATSAKKIVDTFSDAVKTVPLMGEDRNDNEYRRALALVEFLVDHDDLENPLFELLCARISEYEKHAPEFKALN
QHLEKTPPGVSVLRTLMDQYGLKAADLANELGSKSNVSNILNGRRALTVNHIKALTQRFKLPADAFIE

Nucleotide

• Length: 447 bp

>AT207619 NZ_CP103446:c20034-19780 [Erwinia pyrifoliae]
ATGGCATTCAACATACTCACTAATACCGCAGCAAGCATCACGGATTTGAAGCGCGACCCAATGGGCACAGTCCGTGCTGC
CGAAGGGGAAACTATCGCAATTTTAAACCGTAACGAGCCGGCATTTTATTGCGTACCACCCGCTATGTACGCTTATCTGA
TGGAGCTGGCAGAGGATGCTGAGCTTGGATGTATCGTTGACGATCGCATGTCAGAGTTACCGGTTGCGAAAGAGATATCA
TTGGATGACTTATAA

Structures

Toxin

• AlphaFold DB: A0A0R9ME90