Detailed information of TA system TA207618

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): higBA (relBE)/HTH(antitoxin)
• Location: 4540354..4540956
• Replicon: chromosome
• Accession: NZ_CP077706
• Organism: Salmonella enterica subsp. enterica strain CFSAN058545

Toxin (Protein)

• Gene name: higB
• Uniprot ID: A0A3V8XMR3
• Locus tag: DAX52_RS21895
• Protein ID: WP_001159631.1
• Coordinates: 4540645..4540956 (-)
• Length: 104 a.a.

Antitoxin (Protein)

• Gene name: higA
• Uniprot ID: -
• Locus tag: DAX52_RS21890
• Protein ID: WP_000362050.1
• Coordinates: 4540354..4540644 (-)
• Length: 97 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
DAX52_RS21875 (4537847)	4537847..4538749	+	903	WP_000331361.1	formate dehydrogenase subunit beta	-
DAX52_RS21880 (4538746)	4538746..4539381	+	636	WP_000829025.1	formate dehydrogenase cytochrome b556 subunit	-
DAX52_RS21885 (4539378)	4539378..4540307	+	930	WP_070794361.1	formate dehydrogenase accessory protein FdhE	-
DAX52_RS21890 (4540354)	4540354..4540644	-	291	WP_000362050.1	DNA-binding transcriptional regulator	Antitoxin
DAX52_RS21895 (4540645)	4540645..4540956	-	312	WP_001159631.1	cytotoxic translational repressor of toxin-antitoxin stability system	Toxin
DAX52_RS21900 (4541174)	4541174..4542103	+	930	WP_001646963.1	alpha/beta hydrolase	-
DAX52_RS21905 (4542189)	4542189..4542500	+	312	WP_000558166.1	type II toxin-antitoxin system HigB family toxin	-
DAX52_RS21910 (4542497)	4542497..4542943	+	447	WP_001259011.1	type II toxin-antitoxin system HigA family antitoxin	-
DAX52_RS21915 (4542958)	4542958..4543899	-	942	WP_001518251.1	fatty acid biosynthesis protein FabY	-
DAX52_RS21920 (4543944)	4543944..4544381	-	438	WP_000560969.1	D-aminoacyl-tRNA deacylase	-
DAX52_RS21925 (4544378)	4544378..4545250	-	873	WP_000921423.1	virulence factor BrkB family protein	-
DAX52_RS21930 (4545244)	4545244..4545843	-	600	WP_001646959.1	glucose-1-phosphatase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• Cro/C1-type helix-turn-helix domain (36-85)

Sequences

Toxin

Protein

• Length: 104 a.a.
• Molecular weight: 12312.25 Da
• Isoelectric Point: 9.4460

>T207618 WP_001159631.1 NZ_CP077706:c4540956-4540645 [Salmonella enterica subsp. enterica]
MQFIETELFTEDVKKLLDDDEYHKLQVFMAQHPDCGDVIQETGGLRKMRWGARGKGKRSGVRIIYFHRSQRYEVRLLLIY
QKGIKDDLTPQEKAVLRMLNERW

Nucleotide

• Length: 312 bp

>T207618 NZ_CP103446:c18795-18481 [Erwinia pyrifoliae]
ATGCACTTGATAAGCCGTAGCATGATTAAGGATGCCACTGATAAGTACCCGCAGCATTCCAGGGAACTCCTGGCTCTGAT
GATCGCTATTGAAAAAGGGTACTTTAAGGCTCCCGAAGCGTTAAAGGCGGCGTTTCCATCACTGGACAATCTGAAATATT
TAGATAAGCACTACGTTATCAATATTGGCCGCAATGACTTGCGTTTAGTTGCGCTGGTATTTTTTGAGTCTCAAAAATTT
TATGTAAGACATGTGTTTACCCACAAAGAGTACGACGTATTTACAGCGTTACATCGCACAAAGGGGAAAAAATAA

Antitoxin

Protein

• Length: 97 a.a.
• Molecular weight: 10971.59 Da
• Isoelectric Point: 10.6525

>AT207618 WP_000362050.1 NZ_CP077706:c4540644-4540354 [Salmonella enterica subsp. enterica]
MDKVLFERLTQSMSQMNEIIEGTREPSRTFHIDAMKIKEIRQASGLSQSKFAELISVNVDTLRNWEQGRRSPTGPAKALL
RAIANDPRNVIQALRY

Nucleotide

• Length: 291 bp

>AT207618 NZ_CP103446:c18480-18067 [Erwinia pyrifoliae]
ATGCTCGTAGCCGACATCATCAAAGCCGGAGAGGCTTTAACCGCCGTTGCCCCTTTCCTTGCGGGTATTACTGACAAACG
GCAACATGCAGAGGCGCTGGAATTTGTGGAGCACCTTTTACTTAACGACCCGGAAAACCCACTTTTAGATCTGGTTTGTG
CCAAAATCACGGCTTACGAAGACACAGCGCCCGAATTCGCAGAATTTAATGCACAGCTGGCAGCCATGCCGGCAGGCGTT
GCTATGATCCGTTTGCTGCTCGATCAGCACGATTTAACGTTATCCGATTTACCCGAAATCGGTAGCAAATCGATGGTTTC
CCGCGTACTCAATGGCGAGCGTAAACTGACCCTGGAACATGCCAAAAAGTTAGCAACGCGGTTTGCCATATCTCCGGCGT
TGTTCATCGATTAA

Structures

Toxin

• AlphaFold DB: A0A3V8XMR3