Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | higBA (relBE)/HigB-HigA |
| Location | 4654782..4655536 | Replicon | chromosome |
| Accession | NZ_CP077704 | ||
| Organism | Salmonella enterica subsp. enterica strain CFSAN058565 | ||
Toxin (Protein)
| Gene name | higB | Uniprot ID | B5F003 |
| Locus tag | DBO17_RS22660 | Protein ID | WP_000558166.1 |
| Coordinates | 4654782..4655093 (+) | Length | 104 a.a. |
Antitoxin (Protein)
| Gene name | higA | Uniprot ID | - |
| Locus tag | DBO17_RS22665 | Protein ID | WP_079960354.1 |
| Coordinates | 4655090..4655536 (+) | Length | 149 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| DBO17_RS22630 (4650440) | 4650440..4651342 | + | 903 | WP_000331364.1 | formate dehydrogenase subunit beta | - |
| DBO17_RS22635 (4651339) | 4651339..4651974 | + | 636 | WP_000829025.1 | formate dehydrogenase cytochrome b556 subunit | - |
| DBO17_RS22640 (4651971) | 4651971..4652900 | + | 930 | WP_000027730.1 | formate dehydrogenase accessory protein FdhE | - |
| DBO17_RS22645 (4652947) | 4652947..4653237 | - | 291 | WP_000362050.1 | DNA-binding transcriptional regulator | - |
| DBO17_RS22650 (4653238) | 4653238..4653549 | - | 312 | WP_001159635.1 | cytotoxic translational repressor of toxin-antitoxin stability system | - |
| DBO17_RS22655 (4653767) | 4653767..4654696 | + | 930 | WP_108408514.1 | alpha/beta hydrolase | - |
| DBO17_RS22660 (4654782) | 4654782..4655093 | + | 312 | WP_000558166.1 | type II toxin-antitoxin system HigB family toxin | Toxin |
| DBO17_RS22665 (4655090) | 4655090..4655536 | + | 447 | WP_079960354.1 | type II toxin-antitoxin system HigA family antitoxin | Antitoxin |
| DBO17_RS22670 (4655551) | 4655551..4656492 | - | 942 | WP_001518251.1 | fatty acid biosynthesis protein FabY | - |
| DBO17_RS22675 (4656537) | 4656537..4656974 | - | 438 | WP_000560969.1 | D-aminoacyl-tRNA deacylase | - |
| DBO17_RS22680 (4656971) | 4656971..4657843 | - | 873 | WP_000921423.1 | virulence factor BrkB family protein | - |
| DBO17_RS22685 (4657837) | 4657837..4658436 | - | 600 | WP_000965695.1 | glucose-1-phosphatase | - |
| DBO17_RS22690 (4658627) | 4658627..4659430 | - | 804 | WP_000059694.1 | DeoR/GlpR family DNA-binding transcription regulator | - |
| DBO17_RS22695 (4659464) | 4659464..4660360 | - | 897 | WP_001651900.1 | sugar kinase | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 104 a.a. Molecular weight: 12432.40 Da Isoelectric Point: 9.5334
>T207601 WP_000558166.1 NZ_CP077704:4654782-4655093 [Salmonella enterica subsp. enterica]
VHVISRKPFNEAMLMYPNHELALTELLNVLEKKTFTQPEEMKRYIPSLDNFKYRDKWWVIDVSGNSLRLISYIDFRLHKI
FVKHIVSHAEYDKLTAYYRGNKE
VHVISRKPFNEAMLMYPNHELALTELLNVLEKKTFTQPEEMKRYIPSLDNFKYRDKWWVIDVSGNSLRLISYIDFRLHKI
FVKHIVSHAEYDKLTAYYRGNKE
Download Length: 312 bp
>T207601 NZ_CP103420:c4948765-4948478 [Klebsiella variicola]
ATGCCAATGGAGTTTGAGTGGGATGCAAACAAGGCATTAAGTAATCTACGAAAACATGGAGTCCGGTTTGAAGAAGCGGT
ATTAGTCTTTGACGATCCGCGGCACCTTTCCCGCCAGGAGCGGTTTGAGAATGGTGAATATCGCTGGCAGACCATCGGTC
TTGTGCATGGGATCCTTGTTATCCTGGTGGCGCATTCGGTCCGTTTTGAAAGTGGAACTGAGGTTATTCGTATTATCAGC
GCCCGGAAGGCGGACAGAAAAGAGAGGAATCGTTATGAGCATGGTTAA
ATGCCAATGGAGTTTGAGTGGGATGCAAACAAGGCATTAAGTAATCTACGAAAACATGGAGTCCGGTTTGAAGAAGCGGT
ATTAGTCTTTGACGATCCGCGGCACCTTTCCCGCCAGGAGCGGTTTGAGAATGGTGAATATCGCTGGCAGACCATCGGTC
TTGTGCATGGGATCCTTGTTATCCTGGTGGCGCATTCGGTCCGTTTTGAAAGTGGAACTGAGGTTATTCGTATTATCAGC
GCCCGGAAGGCGGACAGAAAAGAGAGGAATCGTTATGAGCATGGTTAA
Antitoxin
Download Length: 149 a.a. Molecular weight: 16749.05 Da Isoelectric Point: 6.0016
>AT207601 WP_079960354.1 NZ_CP077704:4655090-4655536 [Salmonella enterica subsp. enterica]
MRTHRQMDATSAKKIVDTFSDAVKTIPLMGEDRNDNEYRRALALVEFLVDHDDLENPLFELLCARISEYEKHAPEFKALN
QHLEETPPGVSVLRTLMDQYGLKAADLANELGSKSNVSNILNGRRALTVNHIKALTQRFKLPADAFIE
MRTHRQMDATSAKKIVDTFSDAVKTIPLMGEDRNDNEYRRALALVEFLVDHDDLENPLFELLCARISEYEKHAPEFKALN
QHLEETPPGVSVLRTLMDQYGLKAADLANELGSKSNVSNILNGRRALTVNHIKALTQRFKLPADAFIE
Download Length: 447 bp
>AT207601 NZ_CP103420:c4948491-4948189 [Klebsiella variicola]
ATGAGCATGGTTAAACATAAACGCGGCAATACGGCGGCGCTTACCGCTAAGCGTGATGCCGAACTCAAAGCGCTAGCGAG
CAAAGCCGATGAGGATATCGATTACAGCGATATCCCCGCTACAGACGATGCGCAATGGTCAGATGCCGTTCGCGGCAAAT
TTTTTCGACCGCTAAAAACACAGGCTTCTGTGCGCATTGATGCCGATGTCATGGAGTGGCTCAAACGTCCAGGAAAAGGC
TATCAAACTCGACTGAATGCGATTTTAAGAGAAGCGATGATTCGCGATCTTAATAAGAAATAG
ATGAGCATGGTTAAACATAAACGCGGCAATACGGCGGCGCTTACCGCTAAGCGTGATGCCGAACTCAAAGCGCTAGCGAG
CAAAGCCGATGAGGATATCGATTACAGCGATATCCCCGCTACAGACGATGCGCAATGGTCAGATGCCGTTCGCGGCAAAT
TTTTTCGACCGCTAAAAACACAGGCTTCTGTGCGCATTGATGCCGATGTCATGGAGTGGCTCAAACGTCCAGGAAAAGGC
TATCAAACTCGACTGAATGCGATTTTAAGAGAAGCGATGATTCGCGATCTTAATAAGAAATAG
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|