Detailed information of TA system TA207600

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): higBA (relBE)/HTH(antitoxin)
• Location: 4652947..4653549
• Replicon: chromosome
• Accession: NZ_CP077704
• Organism: Salmonella enterica subsp. enterica strain CFSAN058565

Toxin (Protein)

• Gene name: higB
• Uniprot ID: M7S4R6
• Locus tag: DBO17_RS22650
• Protein ID: WP_001159635.1
• Coordinates: 4653238..4653549 (-)
• Length: 104 a.a.

Antitoxin (Protein)

• Gene name: higA
• Uniprot ID: -
• Locus tag: DBO17_RS22645
• Protein ID: WP_000362050.1
• Coordinates: 4652947..4653237 (-)
• Length: 97 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
DBO17_RS22630 (4650440)	4650440..4651342	+	903	WP_000331364.1	formate dehydrogenase subunit beta	-
DBO17_RS22635 (4651339)	4651339..4651974	+	636	WP_000829025.1	formate dehydrogenase cytochrome b556 subunit	-
DBO17_RS22640 (4651971)	4651971..4652900	+	930	WP_000027730.1	formate dehydrogenase accessory protein FdhE	-
DBO17_RS22645 (4652947)	4652947..4653237	-	291	WP_000362050.1	DNA-binding transcriptional regulator	Antitoxin
DBO17_RS22650 (4653238)	4653238..4653549	-	312	WP_001159635.1	cytotoxic translational repressor of toxin-antitoxin stability system	Toxin
DBO17_RS22655 (4653767)	4653767..4654696	+	930	WP_108408514.1	alpha/beta hydrolase	-
DBO17_RS22660 (4654782)	4654782..4655093	+	312	WP_000558166.1	type II toxin-antitoxin system HigB family toxin	-
DBO17_RS22665 (4655090)	4655090..4655536	+	447	WP_079960354.1	type II toxin-antitoxin system HigA family antitoxin	-
DBO17_RS22670 (4655551)	4655551..4656492	-	942	WP_001518251.1	fatty acid biosynthesis protein FabY	-
DBO17_RS22675 (4656537)	4656537..4656974	-	438	WP_000560969.1	D-aminoacyl-tRNA deacylase	-
DBO17_RS22680 (4656971)	4656971..4657843	-	873	WP_000921423.1	virulence factor BrkB family protein	-
DBO17_RS22685 (4657837)	4657837..4658436	-	600	WP_000965695.1	glucose-1-phosphatase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• Cro/C1-type helix-turn-helix domain (36-85)

Sequences

Toxin

Protein

• Length: 104 a.a.
• Molecular weight: 12340.30 Da
• Isoelectric Point: 9.4460

>T207600 WP_001159635.1 NZ_CP077704:c4653549-4653238 [Salmonella enterica subsp. enterica]
MQFIETELFTEDVKKLLDEDEYHKLQVFMAQHPDCGDVIQETGGLRKMRWGARGKGKRSGVRIIYFHRSQRYEIRLLLIY
QKGIKDDLTPQEKAVLRMLNERW

Nucleotide

• Length: 312 bp

>T207600 NZ_CP103420:4341343-4341561 [Klebsiella variicola]
ATGTCTGATAAGCCATTAACTAAAACAGACTATTTGATGCGCTTACGTCGTTGCCAGACAATTGACACGCTGGAGCGCGT
CATTGAAAAAAATAAATATGAACTGTCTGATAATGAACTGGCGGTATTTTACTCAGCCGCCGATCATCGTCTGGCTGAAC
TGACCATGAATAAGCTGTACGATAAGATCCCGACCTCAGTCTGGAAGTTTATCCGCTAA

Antitoxin

Protein

• Length: 97 a.a.
• Molecular weight: 10971.59 Da
• Isoelectric Point: 10.6525

>AT207600 WP_000362050.1 NZ_CP077704:c4653237-4652947 [Salmonella enterica subsp. enterica]
MDKVLFERLTQSMSQMNEIIEGTREPSRTFHIDAMKIKEIRQASGLSQSKFAELISVNVDTLRNWEQGRRSPTGPAKALL
RAIANDPRNVIQALRY

Nucleotide

• Length: 291 bp

>AT207600 NZ_CP103420:4340942-4341316 [Klebsiella variicola]
ATGGACGAATACTCGCCAAAAAGACATGATATTGCACAGCTACGCTTTCTCTGCGAAACGCTGTATCATGACTGCCTTGC
AAACCTGGAAGAGAGCAACCATGGCTGGGTCAACGACCCGACTTCGGCTGTCAATCTTCAGTTAAATGAATTGATCGAGC
ACATTGCCACATTCGCGCTTAATTATAAAATTAAGTACACTGAGGATAATAAACTGGTCGCTCAGGTTGACGAATATCTG
GACGATACTTTTACCTTGTTCAGTAACTACGGCATTAACTCAACGGATTTGCAAAAGTGGAAAAAATCCGGTAATCGACT
ATTTCGTTGCTTTGTCAACGCCAGCCGGGAAAACCCGGCCAGTCTCTCGTGTTAG

Structures

Toxin

• AlphaFold DB: A0A3V2JK97