Detailed information of TA system TA207585

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): higBA (relBE)/COG4683-HTH_37
• Location: 1900563..1901223
• Replicon: chromosome
• Accession: NZ_CP077704
• Organism: Salmonella enterica subsp. enterica strain CFSAN058565

Toxin (Protein)

• Gene name: higB
• Uniprot ID: A0A3Z1E706
• Locus tag: DBO17_RS08995
• Protein ID: WP_000269841.1
• Coordinates: 1900563..1900916 (+)
• Length: 118 a.a.

Antitoxin (Protein)

• Gene name: higA
• Uniprot ID: -
• Locus tag: DBO17_RS09000
• Protein ID: WP_000533827.1
• Coordinates: 1900921..1901223 (+)
• Length: 101 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
DBO17_RS08970 (1896632)	1896632..1897387	+	756	WP_001089671.1	multiubiquitin domain-containing protein	-
DBO17_RS08975 (1897362)	1897362..1898546	+	1185	WP_023203877.1	ThiF family adenylyltransferase	-
DBO17_RS08980 (1898540)	1898540..1899004	+	465	WP_000912782.1	DUF6527 family protein	-
DBO17_RS08985 (1899381)	1899381..1899848	+	468	WP_000201258.1	hypothetical protein	-
DBO17_RS08990 (1899848)	1899848..1900066	+	219	WP_161976074.1	cell morphology transcriptional regulator XreR2	-
DBO17_RS08995 (1900563)	1900563..1900916	+	354	WP_000269841.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
DBO17_RS09000 (1900921)	1900921..1901223	+	303	WP_000533827.1	XRE family transcriptional regulator	Antitoxin
DBO17_RS09005 (1901729)	1901729..1902613	+	885	WP_023203878.1	integrase domain-containing protein	-
DBO17_RS09010 (1903482)	1903482..1904743	-	1262	Protein_1769	integrase arm-type DNA-binding domain-containing protein	-
DBO17_RS09020 (1905081)	1905081..1905878	-	798	WP_108408446.1	DgsA anti-repressor MtfA	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	1875635..1950763	75128

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-like (12-106)

Antitoxin

• Cro/C1-type helix-turn-helix domain (33-81)

Sequences

Toxin

Protein

• Length: 118 a.a.
• Molecular weight: 13477.35 Da
• Isoelectric Point: 9.5699

>T207585 WP_000269841.1 NZ_CP077704:1900563-1900916 [Salmonella enterica subsp. enterica]
VWTIKTTDTFDRWFASLNDTDRVSVLAALLVLREKGPGLSRPYADTVRGSRYSNMKELRIQSRGEPIRAFFAFDPTRTGI
VLCAGNKVGNEKRFYDEMLPVADREFTNWLNTLKEKE

Nucleotide

• Length: 354 bp

>T207585 NZ_CP103419:343298-343645 [Klebsiella variicola]
ATGTGGGATGTAGAAACGACGGATACGTTTGATGCCTGGTTCGAATTACAAAGTAGAGCTTTAAAAGAGGATATGTTGGC
CACGATGCTCATCTTGTCTGAGTTTGGTCCGCAGCTTGGGCGCCCGTATGTTGATACGGTGAAAGATTCAACGTTTCAGA
ATATGAAAGAACTCCGGGTTCAGCATCATGGGCTCCCCATCCGCGCCTTTTTTGCTTTTGATCCTCTGCGGAAAGCTATC
GTTTTATGTGCGGGCAATAAGGATGGCATGAATGAGAAACGTTTTTACAAAGAGATGATTACTCTGGCTGACAGAGAATT
CAGCCAACACCTGACTAAGGAGCGATAA

Antitoxin

Protein

• Length: 101 a.a.
• Molecular weight: 11040.81 Da
• Isoelectric Point: 5.7316

>AT207585 WP_000533827.1 NZ_CP077704:1900921-1901223 [Salmonella enterica subsp. enterica]
MGRTLEQLIADEKPEVVAEAQAMATDILLNIHLAELREKVQKTQVEMAQALGIRQPTVAGMEKPGRDLKLSTLKRYVEAT
GGKLRLDVELPDGSHYGFVL

Nucleotide

• Length: 303 bp

>AT207585 NZ_CP103419:343645-343944 [Klebsiella variicola]
ATGGCCACGCTAAAAGAACTCATGGCGAAACAGAGTCCTGAAAGCCAGCAGCGTATTGCAGCGAAAGCGGCAGAGATACG
CCAGTCTGTCGCTTTAAACTTGCTTCGAGAAGAGTTGCAAATGTCGCAAACAGAGATGGCTGCGGCTATGGGGGTAAAGC
AGCCAACGATCGCTAAAATGGAACAGGCTGATAACGATCCGCGGCTTTCGACCCTAAAACGCTACATTGCGGCATTGGGG
GGAGAACTCAGTATAAATGTCACGTTGCCGACTGGAAAAAAAGTCTCGTTTAATTTGTGA

Structures

Toxin

• AlphaFold DB: A0A3Z1E706