Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | higBA (relBE)/HigB-HigA |
| Location | 31377..32076 | Replicon | plasmid pCFSAN058588 |
| Accession | NZ_CP077703 | ||
| Organism | Salmonella enterica subsp. enterica strain CFSAN058588 | ||
Toxin (Protein)
| Gene name | higB | Uniprot ID | A0A617ZXM9 |
| Locus tag | DAX60_RS22690 | Protein ID | WP_000037759.1 |
| Coordinates | 31774..32076 (-) | Length | 101 a.a. |
Antitoxin (Protein)
| Gene name | higA | Uniprot ID | - |
| Locus tag | DAX60_RS22685 | Protein ID | WP_000806443.1 |
| Coordinates | 31377..31712 (-) | Length | 112 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| DAX60_RS22640 (DAX60_022635) | 26841..27203 | + | 363 | WP_181377893.1 | lysogeny establishment protein | - |
| DAX60_RS22645 (DAX60_022640) | 27200..27358 | + | 159 | WP_001252573.1 | hypothetical protein | - |
| DAX60_RS22650 (DAX60_022645) | 27473..28093 | + | 621 | WP_000527000.1 | hypothetical protein | - |
| DAX60_RS22655 (DAX60_022650) | 28080..28523 | + | 444 | WP_000169636.1 | DUF2591 family protein | - |
| DAX60_RS22660 (DAX60_022655) | 28526..28837 | + | 312 | WP_000934524.1 | hypothetical protein | - |
| DAX60_RS22665 (DAX60_022660) | 28970..29521 | + | 552 | WP_001533528.1 | Ref family recombination enhancement nuclease | - |
| DAX60_RS22670 (DAX60_022665) | 29549..29788 | + | 240 | WP_000354001.1 | hypothetical protein | - |
| DAX60_RS22675 (DAX60_022670) | 29994..30644 | + | 651 | WP_000933936.1 | DUF2829 domain-containing protein | - |
| DAX60_RS22680 (DAX60_022675) | 30742..31320 | + | 579 | WP_023226264.1 | hypothetical protein | - |
| DAX60_RS22685 (DAX60_022680) | 31377..31712 | - | 336 | WP_000806443.1 | HigA family addiction module antitoxin | Antitoxin |
| DAX60_RS22690 (DAX60_022685) | 31774..32076 | - | 303 | WP_000037759.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
| DAX60_RS22695 (DAX60_022690) | 32351..32992 | + | 642 | WP_024133281.1 | hypothetical protein | - |
| DAX60_RS22700 (DAX60_022695) | 33161..33538 | + | 378 | WP_000235963.1 | hypothetical protein | - |
| DAX60_RS22705 (DAX60_022700) | 33551..34768 | + | 1218 | WP_001143859.1 | hypothetical protein | - |
| DAX60_RS22710 (DAX60_022705) | 34772..35512 | + | 741 | WP_000896790.1 | hypothetical protein | - |
| DAX60_RS22715 (DAX60_022710) | 35496..36287 | + | 792 | WP_000224251.1 | hypothetical protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Non-Mobilizable plasmid | - | - | 1..85811 | 85811 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 101 a.a. Molecular weight: 11866.45 Da Isoelectric Point: 9.8539
>T207581 WP_000037759.1 NZ_CP077703:c32076-31774 [Salmonella enterica subsp. enterica]
MSKKINIGSFREAWLDDFFEYSTQHRKIPPDIHTALARKLDIINAATSHRDLRSPPGNRYEELSGKLQDYSSIRINKQYR
LIFRWVNGKAEDLYLDPHKY
MSKKINIGSFREAWLDDFFEYSTQHRKIPPDIHTALARKLDIINAATSHRDLRSPPGNRYEELSGKLQDYSSIRINKQYR
LIFRWVNGKAEDLYLDPHKY
Download Length: 303 bp
>T207581 NZ_CP103415:4237-4593 [Acinetobacter baumannii]
ATGTGGACAGTCATTACAACGGATCTGTTTAATGAATGGCTTGAACAGCAAGATGAAGCAACACAAGAGAAAGTCTTAGC
TGCATTGGTTGTTCTACAACAGCAAGGGCCTAGTTTAGGTCGTCCTTTAGTAGATACCGTCTACGATTCTAAATTTACCA
ATATGAAGGAACTACGTGTTCAGCATCGTGGTAAACCGTTAAGGGCATTTTTTGCATTCGATCCCCTAAGACAAGCGATT
GTGCTGTGTATTGGTGATAAGAGTAATAAAAAGCGTTTTTATACAGAGATGCTAGCAATTGCAGATGAGCAATACGCACT
TCATCTCTCAACTTTAGGAGATCAATCTAATGGCTAA
ATGTGGACAGTCATTACAACGGATCTGTTTAATGAATGGCTTGAACAGCAAGATGAAGCAACACAAGAGAAAGTCTTAGC
TGCATTGGTTGTTCTACAACAGCAAGGGCCTAGTTTAGGTCGTCCTTTAGTAGATACCGTCTACGATTCTAAATTTACCA
ATATGAAGGAACTACGTGTTCAGCATCGTGGTAAACCGTTAAGGGCATTTTTTGCATTCGATCCCCTAAGACAAGCGATT
GTGCTGTGTATTGGTGATAAGAGTAATAAAAAGCGTTTTTATACAGAGATGCTAGCAATTGCAGATGAGCAATACGCACT
TCATCTCTCAACTTTAGGAGATCAATCTAATGGCTAA
Antitoxin
Download Length: 112 a.a. Molecular weight: 12738.60 Da Isoelectric Point: 5.7457
>AT207581 WP_000806443.1 NZ_CP077703:c31712-31377 [Salmonella enterica subsp. enterica]
MKQATRKPTTVGDILLYEYLEPLELKINDLAEMLHVHRNTVSALVNNNRKLTTDMAFRLSKVFDTSVDFWLNLQAAVDLW
EVENDARAQEELSRICTVSDFIAKREAKKAA
MKQATRKPTTVGDILLYEYLEPLELKINDLAEMLHVHRNTVSALVNNNRKLTTDMAFRLSKVFDTSVDFWLNLQAAVDLW
EVENDARAQEELSRICTVSDFIAKREAKKAA
Download Length: 336 bp
>AT207581 NZ_CP103415:4586-4888 [Acinetobacter baumannii]
ATGGCTAAGAGCTTACAAGAATTATTGGCTAGTCGCTCTCCAGAGAGTCAAGCTCGTATTCAAAAAATGGCTGATGAATT
ACTTTTAGAAAGTCAGCTTCACCTTATCCGAGAAGAGTTAGAAATTTCCCAGAAAGAACTAGCTGCAACCCTTGGAATTA
AACAGCCGTCATTATCAGCAATCGAAAATCGTGGTCATGATCTTAAAATTTCAACGATGAAAAAGTATGTTGAAGCAATG
GGTGGAAAACTTCGTATTGATGTAGAGCTTCCAACAGGAAAACACATAGGGTTCAATGTCTAA
ATGGCTAAGAGCTTACAAGAATTATTGGCTAGTCGCTCTCCAGAGAGTCAAGCTCGTATTCAAAAAATGGCTGATGAATT
ACTTTTAGAAAGTCAGCTTCACCTTATCCGAGAAGAGTTAGAAATTTCCCAGAAAGAACTAGCTGCAACCCTTGGAATTA
AACAGCCGTCATTATCAGCAATCGAAAATCGTGGTCATGATCTTAAAATTTCAACGATGAAAAAGTATGTTGAAGCAATG
GGTGGAAAACTTCGTATTGATGTAGAGCTTCCAACAGGAAAACACATAGGGTTCAATGTCTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|