Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | higBA (relBE)/HigB-HigA |
| Location | 4471676..4472430 | Replicon | chromosome |
| Accession | NZ_CP077702 | ||
| Organism | Salmonella enterica subsp. enterica strain CFSAN058588 | ||
Toxin (Protein)
| Gene name | higB | Uniprot ID | A0A629ZU15 |
| Locus tag | DAX60_RS21550 | Protein ID | WP_001528862.1 |
| Coordinates | 4471676..4471987 (+) | Length | 104 a.a. |
Antitoxin (Protein)
| Gene name | higA | Uniprot ID | - |
| Locus tag | DAX60_RS21555 | Protein ID | WP_001259009.1 |
| Coordinates | 4471984..4472430 (+) | Length | 149 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| DAX60_RS21520 (4467334) | 4467334..4468236 | + | 903 | WP_000331361.1 | formate dehydrogenase subunit beta | - |
| DAX60_RS21525 (4468233) | 4468233..4468868 | + | 636 | WP_000829025.1 | formate dehydrogenase cytochrome b556 subunit | - |
| DAX60_RS21530 (4468865) | 4468865..4469794 | + | 930 | WP_000027730.1 | formate dehydrogenase accessory protein FdhE | - |
| DAX60_RS21535 (4469841) | 4469841..4470131 | - | 291 | WP_000362050.1 | DNA-binding transcriptional regulator | - |
| DAX60_RS21540 (4470132) | 4470132..4470443 | - | 312 | WP_001159631.1 | cytotoxic translational repressor of toxin-antitoxin stability system | - |
| DAX60_RS21545 (4470661) | 4470661..4471590 | + | 930 | WP_001127691.1 | alpha/beta hydrolase | - |
| DAX60_RS21550 (4471676) | 4471676..4471987 | + | 312 | WP_001528862.1 | type II toxin-antitoxin system HigB family toxin | Toxin |
| DAX60_RS21555 (4471984) | 4471984..4472430 | + | 447 | WP_001259009.1 | type II toxin-antitoxin system HigA family antitoxin | Antitoxin |
| DAX60_RS21560 (4472445) | 4472445..4473386 | - | 942 | WP_001518251.1 | fatty acid biosynthesis protein FabY | - |
| DAX60_RS21565 (4473431) | 4473431..4473868 | - | 438 | WP_000560969.1 | D-aminoacyl-tRNA deacylase | - |
| DAX60_RS21570 (4473865) | 4473865..4474737 | - | 873 | WP_000921423.1 | virulence factor BrkB family protein | - |
| DAX60_RS21575 (4474731) | 4474731..4475330 | - | 600 | WP_000965695.1 | glucose-1-phosphatase | - |
| DAX60_RS21580 (4475521) | 4475521..4476324 | - | 804 | WP_000059693.1 | DeoR/GlpR family DNA-binding transcription regulator | - |
| DAX60_RS21585 (4476358) | 4476358..4477254 | - | 897 | WP_001528888.1 | sugar kinase | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 104 a.a. Molecular weight: 12464.46 Da Isoelectric Point: 9.5334
>T207580 WP_001528862.1 NZ_CP077702:4471676-4471987 [Salmonella enterica subsp. enterica]
VHVISRKPFNEAMLMYPNHELALTELLNVLEKKTFTQPEEMKRYIPSLDNFKYRDKWWMIDVSGNSLRLISYIDFRLHKI
FVKHIVSHAEYDKLTAYYRGNKE
VHVISRKPFNEAMLMYPNHELALTELLNVLEKKTFTQPEEMKRYIPSLDNFKYRDKWWMIDVSGNSLRLISYIDFRLHKI
FVKHIVSHAEYDKLTAYYRGNKE
Download Length: 312 bp
>T207580 NZ_CP077702:4471676-4471987 [Salmonella enterica subsp. enterica]
GTGCATGTTATCAGCCGAAAACCGTTCAATGAAGCGATGCTCATGTATCCAAACCATGAGCTTGCCCTCACTGAGTTGCT
GAATGTTCTTGAGAAAAAAACATTCACTCAGCCTGAAGAGATGAAGCGGTATATTCCTTCACTGGATAATTTTAAGTACA
GAGATAAATGGTGGATGATTGATGTTTCTGGTAACAGCCTGAGACTCATTTCCTACATAGATTTCAGGTTACATAAGATA
TTTGTGAAACATATCGTTTCCCATGCCGAATATGACAAACTGACCGCATATTATCGGGGTAATAAAGAATGA
GTGCATGTTATCAGCCGAAAACCGTTCAATGAAGCGATGCTCATGTATCCAAACCATGAGCTTGCCCTCACTGAGTTGCT
GAATGTTCTTGAGAAAAAAACATTCACTCAGCCTGAAGAGATGAAGCGGTATATTCCTTCACTGGATAATTTTAAGTACA
GAGATAAATGGTGGATGATTGATGTTTCTGGTAACAGCCTGAGACTCATTTCCTACATAGATTTCAGGTTACATAAGATA
TTTGTGAAACATATCGTTTCCCATGCCGAATATGACAAACTGACCGCATATTATCGGGGTAATAAAGAATGA
Antitoxin
Download Length: 149 a.a. Molecular weight: 16720.06 Da Isoelectric Point: 6.6451
>AT207580 WP_001259009.1 NZ_CP077702:4471984-4472430 [Salmonella enterica subsp. enterica]
MRTHRQMDATSAKKIVDTFSDAVKSVPLMGEDRNDNEYRRALALVEFLVDHDDLENPLFELLCARISEYEKHAPEFKALN
QHLEKTPPGVSVLRTLMDQYGLKAADLANELGSKSNVSNILNGRRALTVNHIKALTQRFKLPADAFIE
MRTHRQMDATSAKKIVDTFSDAVKSVPLMGEDRNDNEYRRALALVEFLVDHDDLENPLFELLCARISEYEKHAPEFKALN
QHLEKTPPGVSVLRTLMDQYGLKAADLANELGSKSNVSNILNGRRALTVNHIKALTQRFKLPADAFIE
Download Length: 447 bp
>AT207580 NZ_CP077702:4471984-4472430 [Salmonella enterica subsp. enterica]
ATGAGAACTCATCGTCAGATGGATGCAACCAGCGCAAAAAAGATCGTTGATACCTTCAGCGATGCGGTAAAAAGCGTCCC
ACTGATGGGGGAAGACCGAAATGACAATGAGTATCGCAGGGCACTAGCGCTAGTGGAGTTTCTGGTCGACCACGACGATC
TTGAAAACCCACTATTTGAATTGCTCTGTGCCCGAATCAGTGAATACGAAAAACATGCGCCGGAATTCAAAGCACTCAAC
CAACACCTGGAGAAAACGCCCCCTGGCGTTTCAGTATTGCGAACGCTCATGGATCAATACGGTCTCAAAGCAGCAGATCT
TGCCAACGAACTTGGTTCTAAATCGAACGTCAGCAACATCTTAAATGGCCGCAGAGCACTAACGGTTAATCATATTAAAG
CGCTTACACAACGCTTTAAACTACCAGCGGATGCCTTCATCGAGTAG
ATGAGAACTCATCGTCAGATGGATGCAACCAGCGCAAAAAAGATCGTTGATACCTTCAGCGATGCGGTAAAAAGCGTCCC
ACTGATGGGGGAAGACCGAAATGACAATGAGTATCGCAGGGCACTAGCGCTAGTGGAGTTTCTGGTCGACCACGACGATC
TTGAAAACCCACTATTTGAATTGCTCTGTGCCCGAATCAGTGAATACGAAAAACATGCGCCGGAATTCAAAGCACTCAAC
CAACACCTGGAGAAAACGCCCCCTGGCGTTTCAGTATTGCGAACGCTCATGGATCAATACGGTCTCAAAGCAGCAGATCT
TGCCAACGAACTTGGTTCTAAATCGAACGTCAGCAACATCTTAAATGGCCGCAGAGCACTAACGGTTAATCATATTAAAG
CGCTTACACAACGCTTTAAACTACCAGCGGATGCCTTCATCGAGTAG
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|