Detailed information of TA system TA207579

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): higBA (relBE)/HTH(antitoxin)
• Location: 4469841..4470443
• Replicon: chromosome
• Accession: NZ_CP077702
• Organism: Salmonella enterica subsp. enterica strain CFSAN058588

Toxin (Protein)

• Gene name: higB
• Uniprot ID: A0A3V8XMR3
• Locus tag: DAX60_RS21540
• Protein ID: WP_001159631.1
• Coordinates: 4470132..4470443 (-)
• Length: 104 a.a.

Antitoxin (Protein)

• Gene name: higA
• Uniprot ID: -
• Locus tag: DAX60_RS21535
• Protein ID: WP_000362050.1
• Coordinates: 4469841..4470131 (-)
• Length: 97 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
DAX60_RS21520 (4467334)	4467334..4468236	+	903	WP_000331361.1	formate dehydrogenase subunit beta	-
DAX60_RS21525 (4468233)	4468233..4468868	+	636	WP_000829025.1	formate dehydrogenase cytochrome b556 subunit	-
DAX60_RS21530 (4468865)	4468865..4469794	+	930	WP_000027730.1	formate dehydrogenase accessory protein FdhE	-
DAX60_RS21535 (4469841)	4469841..4470131	-	291	WP_000362050.1	DNA-binding transcriptional regulator	Antitoxin
DAX60_RS21540 (4470132)	4470132..4470443	-	312	WP_001159631.1	cytotoxic translational repressor of toxin-antitoxin stability system	Toxin
DAX60_RS21545 (4470661)	4470661..4471590	+	930	WP_001127691.1	alpha/beta hydrolase	-
DAX60_RS21550 (4471676)	4471676..4471987	+	312	WP_001528862.1	type II toxin-antitoxin system HigB family toxin	-
DAX60_RS21555 (4471984)	4471984..4472430	+	447	WP_001259009.1	type II toxin-antitoxin system HigA family antitoxin	-
DAX60_RS21560 (4472445)	4472445..4473386	-	942	WP_001518251.1	fatty acid biosynthesis protein FabY	-
DAX60_RS21565 (4473431)	4473431..4473868	-	438	WP_000560969.1	D-aminoacyl-tRNA deacylase	-
DAX60_RS21570 (4473865)	4473865..4474737	-	873	WP_000921423.1	virulence factor BrkB family protein	-
DAX60_RS21575 (4474731)	4474731..4475330	-	600	WP_000965695.1	glucose-1-phosphatase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• Cro/C1-type helix-turn-helix domain (36-85)

Sequences

Toxin

Protein

• Length: 104 a.a.
• Molecular weight: 12312.25 Da
• Isoelectric Point: 9.4460

>T207579 WP_001159631.1 NZ_CP077702:c4470443-4470132 [Salmonella enterica subsp. enterica]
MQFIETELFTEDVKKLLDDDEYHKLQVFMAQHPDCGDVIQETGGLRKMRWGARGKGKRSGVRIIYFHRSQRYEVRLLLIY
QKGIKDDLTPQEKAVLRMLNERW

Nucleotide

• Length: 312 bp

>T207579 NZ_CP103413:450842-451231 [Acinetobacter baumannii]
TTGATCAACCATTTGAATTTTAAGCTGAAATATAGTCGTTTTTCGATTATATTTCAGTTTTTTATTGGCTTAAGCTTAGC
AGTTCTATTTTATCAATTAATGCCGTTACTATGGTGGTTAGTTGTAATCAGCTTACTATTTATCAGCTTTATTTTCTTTT
TAAAGCGTCCGCAGCTTGCACAAATTGCTTATTTAGATAAAAAACTATGGTCGCTTGCTTATAAGTCACAGAACACCGTT
TCTCGCGTCAAAATTTTAAAAATAATTGATTGTCAGATTTTCATAGTGATCTATTTTGAAGGTCATAAAACACTAACTTC
TATCATTTGGTTTGATCAAATGTCATTAGCAGAGTGGAAAAAGCTTAAAACTTTAGAAAAACTCTATTAA

Antitoxin

Protein

• Length: 97 a.a.
• Molecular weight: 10971.59 Da
• Isoelectric Point: 10.6525

>AT207579 WP_000362050.1 NZ_CP077702:c4470131-4469841 [Salmonella enterica subsp. enterica]
MDKVLFERLTQSMSQMNEIIEGTREPSRTFHIDAMKIKEIRQASGLSQSKFAELISVNVDTLRNWEQGRRSPTGPAKALL
RAIANDPRNVIQALRY

Nucleotide

• Length: 291 bp

>AT207579 NZ_CP103413:450578-450835 [Acinetobacter baumannii]
ATGTCTGAAGAAATGACCTTGGAAGAACGTAAAGTAATCTATCGCGCACGTCGTGGTTTAAAGGAAATTGATGTCTATTT
TGACCCTTATGTGAAAAATTATTATTTAAAGGCAGACCCGGCAGAAAAAGCGTTGTTTGCTGAGTTGGTAGAACAGGAAG
ACCCTGATTTACTAGATTGGTTTATGGAAGTATCAGAACCACCACGTACCGAATTACGTGACTTTATCTATAAATTAAAA
CACTATGTTCATGGTTAA

Structures

Toxin

• AlphaFold DB: A0A3V8XMR3