Detailed information of TA system TA207560

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): higBA (relBE)/HTH(antitoxin)
• Location: 4687451..4688053
• Replicon: chromosome
• Accession: NZ_CP077699
• Organism: Salmonella enterica subsp. enterica strain CFSAN058591

Toxin (Protein)

• Gene name: higB
• Uniprot ID: A0A3V8XMR3
• Locus tag: DAY16_RS22720
• Protein ID: WP_001159631.1
• Coordinates: 4687742..4688053 (-)
• Length: 104 a.a.

Antitoxin (Protein)

• Gene name: higA
• Uniprot ID: -
• Locus tag: DAY16_RS22715
• Protein ID: WP_000362050.1
• Coordinates: 4687451..4687741 (-)
• Length: 97 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
DAY16_RS22700 (4684944)	4684944..4685846	+	903	WP_000331361.1	formate dehydrogenase subunit beta	-
DAY16_RS22705 (4685843)	4685843..4686478	+	636	WP_000829025.1	formate dehydrogenase cytochrome b556 subunit	-
DAY16_RS22710 (4686475)	4686475..4687404	+	930	WP_070794361.1	formate dehydrogenase accessory protein FdhE	-
DAY16_RS22715 (4687451)	4687451..4687741	-	291	WP_000362050.1	DNA-binding transcriptional regulator	Antitoxin
DAY16_RS22720 (4687742)	4687742..4688053	-	312	WP_001159631.1	cytotoxic translational repressor of toxin-antitoxin stability system	Toxin
DAY16_RS22725 (4688271)	4688271..4689200	+	930	WP_001646963.1	alpha/beta hydrolase	-
DAY16_RS22730 (4689286)	4689286..4689597	+	312	WP_000558166.1	type II toxin-antitoxin system HigB family toxin	-
DAY16_RS22735 (4689594)	4689594..4690040	+	447	WP_001259011.1	type II toxin-antitoxin system HigA family antitoxin	-
DAY16_RS22740 (4690055)	4690055..4690996	-	942	WP_001518251.1	fatty acid biosynthesis protein FabY	-
DAY16_RS22745 (4691041)	4691041..4691478	-	438	WP_000560969.1	D-aminoacyl-tRNA deacylase	-
DAY16_RS22750 (4691475)	4691475..4692347	-	873	WP_000921423.1	virulence factor BrkB family protein	-
DAY16_RS22755 (4692341)	4692341..4692940	-	600	WP_001646959.1	glucose-1-phosphatase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• Cro/C1-type helix-turn-helix domain (36-85)

Sequences

Toxin

Protein

• Length: 104 a.a.
• Molecular weight: 12312.25 Da
• Isoelectric Point: 9.4460

>T207560 WP_001159631.1 NZ_CP077699:c4688053-4687742 [Salmonella enterica subsp. enterica]
MQFIETELFTEDVKKLLDDDEYHKLQVFMAQHPDCGDVIQETGGLRKMRWGARGKGKRSGVRIIYFHRSQRYEVRLLLIY
QKGIKDDLTPQEKAVLRMLNERW

Nucleotide

• Length: 312 bp

>T207560 NZ_CP103351:c1373989-1373243 [Bacillus subtilis]
ATGGTTTTATTCTTTCAGATCATGGTCTGGTGCATCGTGGCCGGACTGGGGTTATACGTGTATGCCACGTGGCGTTTCGA
AGCGAAGGTCAAAGAAAAAATGTCCGCCATTCGGAAAACTTGGTATTTGCTGTTTGTTCTGGGCGCTATGGTATACTGGA
CATATGAGCCCACTTCCCTATTTACCCACTGGGAACGGTATCTCATTGTCGCAGTCAGTTTTGCTTTGATTGATGCTTTT
ATCTTCTTAAGTGCATATGTCAAAAAACTGGCCGGCAGCGAGCTTGAAACAGACACAAGAGAAATTCTTGAAGAAAACAA
CGAAATGCTCCACATGTATCTCAATCGGCTGAAAACATACCAATACCTATTGAAAAACGAACCGATCCATGTTTATTATG
GAAGTATAGATGCTTATGCTGAAGGTATTGATAAGCTGCTGAAAACCTATGCTGATAAAATGAACTTAACGGCTTCTCTT
TGCCACTATTCGACACAGGCTGATAAAGACCGGTTAACCGAGCATATGGATGATCCGGCAGATGTACAAACACGGCTCGA
TCGAAAGGATGTTTATTACGACCAATACGGAAAAGTGGTTCTCATCCCTTTTACCATCGAGACACAGAACTATGTCATCA
AGCTGACGTCTGACAGCATTGTCACGGAATTTGATTATTTGCTATTTACGTCATTAACGAGCATATATGATTTGGTGCTG
CCAATTGAGGAGGAAGGTGAAGGATAA

Antitoxin

Protein

• Length: 97 a.a.
• Molecular weight: 10971.59 Da
• Isoelectric Point: 10.6525

>AT207560 WP_000362050.1 NZ_CP077699:c4687741-4687451 [Salmonella enterica subsp. enterica]
MDKVLFERLTQSMSQMNEIIEGTREPSRTFHIDAMKIKEIRQASGLSQSKFAELISVNVDTLRNWEQGRRSPTGPAKALL
RAIANDPRNVIQALRY

Nucleotide

• Length: 291 bp

>AT207560 NZ_CP103351:c1373243-1373073 [Bacillus subtilis]
ATGGAACGTGCGTTTCAAAACAGATGCGAGCCCAGAGCGGCGAAGCCGTTTAAAATCCTGAAAAAACGTTCAACCACCAG
TGTCGCAAGCTATCAAGTCAGTCCGCATACAGCAAGAATCTTCAAAGAAAACGAACGGCTGATTGACGAGTATAAACGAA
AAAAAGCATGA

Structures

Toxin

• AlphaFold DB: A0A3V8XMR3