Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 4608326..4609080 Replicon chromosome
Accession NZ_CP077696
Organism Salmonella enterica subsp. enterica strain CFSAN058598

Toxin (Protein)


Gene name higB Uniprot ID B5F003
Locus tag DAX72_RS22670 Protein ID WP_000558166.1
Coordinates 4608326..4608637 (+) Length 104 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag DAX72_RS22675 Protein ID WP_001259009.1
Coordinates 4608634..4609080 (+) Length 149 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DAX72_RS22640 (4603984) 4603984..4604886 + 903 WP_000331361.1 formate dehydrogenase subunit beta -
DAX72_RS22645 (4604883) 4604883..4605518 + 636 WP_000829025.1 formate dehydrogenase cytochrome b556 subunit -
DAX72_RS22650 (4605515) 4605515..4606444 + 930 WP_108411810.1 formate dehydrogenase accessory protein FdhE -
DAX72_RS22655 (4606491) 4606491..4606781 - 291 WP_000362050.1 DNA-binding transcriptional regulator -
DAX72_RS22660 (4606782) 4606782..4607093 - 312 WP_001159631.1 cytotoxic translational repressor of toxin-antitoxin stability system -
DAX72_RS22665 (4607311) 4607311..4608240 + 930 WP_001127691.1 alpha/beta hydrolase -
DAX72_RS22670 (4608326) 4608326..4608637 + 312 WP_000558166.1 type II toxin-antitoxin system HigB family toxin Toxin
DAX72_RS22675 (4608634) 4608634..4609080 + 447 WP_001259009.1 type II toxin-antitoxin system HigA family antitoxin Antitoxin
DAX72_RS22680 (4609095) 4609095..4610036 - 942 WP_001518251.1 fatty acid biosynthesis protein FabY -
DAX72_RS22685 (4610081) 4610081..4610518 - 438 WP_000560974.1 D-aminoacyl-tRNA deacylase -
DAX72_RS22690 (4610515) 4610515..4611387 - 873 WP_000921423.1 virulence factor BrkB family protein -
DAX72_RS22695 (4611381) 4611381..4611980 - 600 WP_000965695.1 glucose-1-phosphatase -
DAX72_RS22700 (4612171) 4612171..4612974 - 804 WP_000059693.1 DeoR/GlpR family DNA-binding transcription regulator -
DAX72_RS22705 (4613008) 4613008..4613904 - 897 WP_001520529.1 sugar kinase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, mRNA interferase HigB

(21-93)

Antitoxin

Cro/C1-type helix-turn-helix domain

(93-146)


Sequences

Toxin        


Download         Length: 104 a.a.        Molecular weight: 12432.40 Da        Isoelectric Point: 9.5334

>T207541 WP_000558166.1 NZ_CP077696:4608326-4608637 [Salmonella enterica subsp. enterica]
VHVISRKPFNEAMLMYPNHELALTELLNVLEKKTFTQPEEMKRYIPSLDNFKYRDKWWVIDVSGNSLRLISYIDFRLHKI
FVKHIVSHAEYDKLTAYYRGNKE

Download         Length: 312 bp

>T207541 NZ_CP103333:13104-13253 [Escherichia coli]
ATGACGAAATATGCCCTTATCGGGTTGCTCGCCGTGTGTGCCACGGTATTGTGTTTTTCACTGATATTCAGGGAACGGTT
ATGTGAACTGAATATTCACAGGGGAAATACAGTGGTGCAGGTAACTCTGGCCTACGAAGCACGGAAGTAA

Antitoxin


Download         Length: 149 a.a.        Molecular weight: 16720.06 Da        Isoelectric Point: 6.6451

>AT207541 WP_001259009.1 NZ_CP077696:4608634-4609080 [Salmonella enterica subsp. enterica]
MRTHRQMDATSAKKIVDTFSDAVKSVPLMGEDRNDNEYRRALALVEFLVDHDDLENPLFELLCARISEYEKHAPEFKALN
QHLEKTPPGVSVLRTLMDQYGLKAADLANELGSKSNVSNILNGRRALTVNHIKALTQRFKLPADAFIE

Download         Length: 447 bp

>AT207541 NZ_CP103333:c13059-13000 [Escherichia coli]
TAAGTACTTCATGCAGACCTCACGAGTTAATGGATTAACGAGTGGGGTCTTCGCATTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0R9ME90

Antitoxin

Source ID Structure

References