Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | higBA (relBE)/Tad-HTH_37 |
| Location | 1885517..1886144 | Replicon | chromosome |
| Accession | NZ_CP077696 | ||
| Organism | Salmonella enterica subsp. enterica strain CFSAN058598 | ||
Toxin (Protein)
| Gene name | higB | Uniprot ID | A0A5Y2FSH1 |
| Locus tag | DAX72_RS24430 | Protein ID | WP_024131287.1 |
| Coordinates | 1885815..1886144 (-) | Length | 110 a.a. |
Antitoxin (Protein)
| Gene name | higA | Uniprot ID | - |
| Locus tag | DAX72_RS24425 | Protein ID | WP_000147078.1 |
| Coordinates | 1885517..1885825 (-) | Length | 103 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| DAX72_RS08725 (1880774) | 1880774..1881601 | - | 828 | WP_053299710.1 | DUF2303 family protein | - |
| DAX72_RS08730 (1881659) | 1881659..1882030 | - | 372 | WP_000997190.1 | hypothetical protein | - |
| DAX72_RS08735 (1882730) | 1882730..1883005 | - | 276 | WP_001514782.1 | hypothetical protein | - |
| DAX72_RS08740 (1883007) | 1883007..1883258 | - | 252 | WP_001574551.1 | hypothetical protein | - |
| DAX72_RS08745 (1883186) | 1883186..1883371 | - | 186 | WP_108411815.1 | ClpX C4-type zinc finger protein | - |
| DAX72_RS08750 (1883576) | 1883576..1884271 | - | 696 | WP_053299709.1 | helix-turn-helix transcriptional regulator | - |
| DAX72_RS08755 (1884369) | 1884369..1884593 | + | 225 | WP_001191666.1 | helix-turn-helix transcriptional regulator | - |
| DAX72_RS08760 (1884622) | 1884622..1885176 | + | 555 | WP_000509731.1 | YmfL family putative regulatory protein | - |
| DAX72_RS24420 (1885322) | 1885322..1885498 | + | 177 | WP_000281065.1 | DUF4222 domain-containing protein | - |
| DAX72_RS24425 (1885517) | 1885517..1885825 | - | 309 | WP_000147078.1 | helix-turn-helix transcriptional regulator | Antitoxin |
| DAX72_RS24430 (1885815) | 1885815..1886144 | - | 330 | WP_024131287.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
| DAX72_RS24435 (1886058) | 1886058..1887023 | + | 966 | WP_223196747.1 | Rha family phage regulatory protein | - |
| DAX72_RS08770 (1887020) | 1887020..1887244 | + | 225 | WP_000620702.1 | hypothetical protein | - |
| DAX72_RS08775 (1887241) | 1887241..1888203 | + | 963 | WP_108411816.1 | conserved phage C-terminal domain-containing protein | - |
| DAX72_RS08780 (1888200) | 1888200..1888673 | + | 474 | WP_000054227.1 | PerC family transcriptional regulator | - |
| DAX72_RS08785 (1888670) | 1888670..1889551 | + | 882 | WP_000200166.1 | Dam family site-specific DNA-(adenine-N6)-methyltransferase | - |
| DAX72_RS08790 (1889560) | 1889560..1889949 | + | 390 | WP_000779149.1 | RusA family crossover junction endodeoxyribonuclease | - |
| DAX72_RS08795 (1889966) | 1889966..1890826 | + | 861 | WP_001061452.1 | KilA-N domain-containing protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Prophage | - | sseK2 | 1875503..1921813 | 46310 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 110 a.a. Molecular weight: 12781.80 Da Isoelectric Point: 9.8238
>T207528 WP_024131287.1 NZ_CP077696:c1886144-1885815 [Salmonella enterica subsp. enterica]
MNYTIEYYNEEVRIEVDQLPLSMRARYQHLVERMKVYGSNLGEPHTSAFGDGLFELRIKGSDGIARVFYCTLAGKRIVML
HSFIKKTQKTPVAERKKAETRMKEVKHDW
MNYTIEYYNEEVRIEVDQLPLSMRARYQHLVERMKVYGSNLGEPHTSAFGDGLFELRIKGSDGIARVFYCTLAGKRIVML
HSFIKKTQKTPVAERKKAETRMKEVKHDW
Download Length: 330 bp
>T207528 NZ_CP103329:1880242-1880493 [Escherichia coli]
ATGCGTACAATTAGTTACAGCGAAGCGCGTCAGAATTTGTCGGCAACAATGATGAAAGCCGTTGAAGATCATGCCCCGAT
CCTTATTACTCGTCAGAATGGAGAGGCTTGTGTTCTGATGTCACTCGAAGAATACAACTCGCTGGAAGAGACGGCTTATC
TACTGCGTTCCCCCGCTAACGCCCGGAGATTGATGGACTCAATCGATAGCCTGAAATCAGGCAAAGGAACGGAAAAGGAC
ATTATTGAGTGA
ATGCGTACAATTAGTTACAGCGAAGCGCGTCAGAATTTGTCGGCAACAATGATGAAAGCCGTTGAAGATCATGCCCCGAT
CCTTATTACTCGTCAGAATGGAGAGGCTTGTGTTCTGATGTCACTCGAAGAATACAACTCGCTGGAAGAGACGGCTTATC
TACTGCGTTCCCCCGCTAACGCCCGGAGATTGATGGACTCAATCGATAGCCTGAAATCAGGCAAAGGAACGGAAAAGGAC
ATTATTGAGTGA
Antitoxin
Download Length: 103 a.a. Molecular weight: 11110.77 Da Isoelectric Point: 7.0152
>AT207528 WP_000147078.1 NZ_CP077696:c1885825-1885517 [Salmonella enterica subsp. enterica]
MTGKRNAPTITHDEMAAKWMEDPAFKAEYDAIADEFALLDEMLAARKEAGLTQAEVAERMGTKATAITRMESNLAAGVSG
PSFTTLKKFAQATGKKLQIRFV
MTGKRNAPTITHDEMAAKWMEDPAFKAEYDAIADEFALLDEMLAARKEAGLTQAEVAERMGTKATAITRMESNLAAGVSG
PSFTTLKKFAQATGKKLQIRFV
Download Length: 309 bp
>AT207528 NZ_CP103329:1880490-1880744 [Escherichia coli]
GTGAAACTAATCTGGTCTGAGGAGTCATGGGATGATTATCTGTACTGGCAGGAAACAGATAAGCGAATTGTTAAAAAGAT
CAATGAACTTATCAAAGATACCCGCAGAACACCATTTGAAGGTAAGGGGAAGCCAGAACCCCTGAAGCATAATTTGTCAG
GCTTCTGGTCCCGACGCATTACAGAGGAGCACCGTCTGGTATACGCGGTTACTGACGATTCACTGCTCATTGCAGCATGT
CGTTATCATTATTGA
GTGAAACTAATCTGGTCTGAGGAGTCATGGGATGATTATCTGTACTGGCAGGAAACAGATAAGCGAATTGTTAAAAAGAT
CAATGAACTTATCAAAGATACCCGCAGAACACCATTTGAAGGTAAGGGGAAGCCAGAACCCCTGAAGCATAATTTGTCAG
GCTTCTGGTCCCGACGCATTACAGAGGAGCACCGTCTGGTATACGCGGTTACTGACGATTCACTGCTCATTGCAGCATGT
CGTTATCATTATTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|