Detailed information of TA system TA207520

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): higBA (relBE)/HTH(antitoxin)
• Location: 4879109..4879711
• Replicon: chromosome
• Accession: NZ_CP077693
• Organism: Salmonella enterica subsp. enterica strain CFSAN058605

Toxin (Protein)

• Gene name: higB
• Uniprot ID: C0Q3J8
• Locus tag: DAY14_RS23970
• Protein ID: WP_001159630.1
• Coordinates: 4879400..4879711 (-)
• Length: 104 a.a.

Antitoxin (Protein)

• Gene name: higA
• Uniprot ID: -
• Locus tag: DAY14_RS23965
• Protein ID: WP_000362050.1
• Coordinates: 4879109..4879399 (-)
• Length: 97 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
DAY14_RS23950 (4876602)	4876602..4877504	+	903	WP_000331361.1	formate dehydrogenase subunit beta	-
DAY14_RS23955 (4877501)	4877501..4878136	+	636	WP_000829025.1	formate dehydrogenase cytochrome b556 subunit	-
DAY14_RS23960 (4878133)	4878133..4879062	+	930	WP_000027730.1	formate dehydrogenase accessory protein FdhE	-
DAY14_RS23965 (4879109)	4879109..4879399	-	291	WP_000362050.1	DNA-binding transcriptional regulator	Antitoxin
DAY14_RS23970 (4879400)	4879400..4879711	-	312	WP_001159630.1	cytotoxic translational repressor of toxin-antitoxin stability system	Toxin
DAY14_RS23975 (4879929)	4879929..4880858	+	930	WP_021294279.1	alpha/beta hydrolase	-
DAY14_RS23980 (4880944)	4880944..4881255	+	312	WP_000558166.1	type II toxin-antitoxin system HigB family toxin	-
DAY14_RS23985 (4881252)	4881252..4881698	+	447	WP_001259012.1	type II toxin-antitoxin system HigA family antitoxin	-
DAY14_RS23990 (4881713)	4881713..4882654	-	942	WP_001518251.1	fatty acid biosynthesis protein FabY	-
DAY14_RS23995 (4882699)	4882699..4883136	-	438	WP_001621365.1	D-aminoacyl-tRNA deacylase	-
DAY14_RS24000 (4883133)	4883133..4884005	-	873	WP_000921423.1	virulence factor BrkB family protein	-
DAY14_RS24005 (4883999)	4883999..4884598	-	600	WP_000965695.1	glucose-1-phosphatase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• Cro/C1-type helix-turn-helix domain (36-85)

Sequences

Toxin

Protein

• Length: 104 a.a.
• Molecular weight: 12326.27 Da
• Isoelectric Point: 9.4460

>T207520 WP_001159630.1 NZ_CP077693:c4879711-4879400 [Salmonella enterica subsp. enterica]
MQFIETELFTEDVKKLLDDDEYHKLQVFMAQHPDCGDVIQETGGLRKMRWGARGKGKRSGVRIIYFHRSQRYEIRLLLIY
QKGIKDDLTPQEKAVLRMLNERW

Nucleotide

• Length: 312 bp

>T207520 NZ_CP103329:298218-298448 [Escherichia coli]
CTGGATCAGCTATTTAAATCACCTTTACCTCAAGGAATCAAATGGACTGATATAGAATCTCTGGTTAAAGCGTTAGGCGG
AGAAATTAAGGAAGGTAGGGGGTCGCGCTGTAAGTTCATACTAAATATGAGCGTTGCGTGTTTCCATCGGCCTCATCCGT
CGCCAGATACCGATAAAGGCGCTGTAGAAAGCGTGCGTGACTGGTTACTAAGTATAGGGGTAAAACCATGA

Antitoxin

Protein

• Length: 97 a.a.
• Molecular weight: 10971.59 Da
• Isoelectric Point: 10.6525

>AT207520 WP_000362050.1 NZ_CP077693:c4879399-4879109 [Salmonella enterica subsp. enterica]
MDKVLFERLTQSMSQMNEIIEGTREPSRTFHIDAMKIKEIRQASGLSQSKFAELISVNVDTLRNWEQGRRSPTGPAKALL
RAIANDPRNVIQALRY

Nucleotide

• Length: 291 bp

>AT207520 NZ_CP103329:298445-298804 [Escherichia coli]
ATGATCAAACTGAAGACGCCAAACTCTATGGAGATTGCCGGGCAACCTGCTGTTATCACTTACGTGCCAGAACTGAATGC
ATTTCGTGGCAAATTCCTGGGCTTGTCAGGTTATTGTGATTTTGTCTCTGACAGCATTCAGGGGCTGCAAAAAGAAGGGG
AACTTTCCCTGCGAGAGTATCTTGAGGATTGTAAAGCTGCGGGTATTGAGCCGTATGCGCGTACAGAAAAGATTAAGACC
TTTACGTTACGCTATCCAGAATCGCTGAGTGAACGCCTTAATAATGCGGCTGCGCAGCAACAAGTCTCTGTTAATACCTA
TATTATTGAAACACTGAATGAGCGTTTGAATCATTTATAA

Structures

Toxin

• AlphaFold DB: A0A0R9NS64