Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | higBA (relBE)/HigB-HigA |
| Location | 4859726..4860480 | Replicon | chromosome |
| Accession | NZ_CP077691 | ||
| Organism | Salmonella enterica subsp. enterica strain CFSAN058620 | ||
Toxin (Protein)
| Gene name | higB | Uniprot ID | B5F003 |
| Locus tag | DAX98_RS23850 | Protein ID | WP_000558166.1 |
| Coordinates | 4859726..4860037 (+) | Length | 104 a.a. |
Antitoxin (Protein)
| Gene name | higA | Uniprot ID | - |
| Locus tag | DAX98_RS23855 | Protein ID | WP_001259012.1 |
| Coordinates | 4860034..4860480 (+) | Length | 149 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| DAX98_RS23820 (4855384) | 4855384..4856286 | + | 903 | WP_000331361.1 | formate dehydrogenase subunit beta | - |
| DAX98_RS23825 (4856283) | 4856283..4856918 | + | 636 | WP_000829025.1 | formate dehydrogenase cytochrome b556 subunit | - |
| DAX98_RS23830 (4856915) | 4856915..4857844 | + | 930 | WP_000027730.1 | formate dehydrogenase accessory protein FdhE | - |
| DAX98_RS23835 (4857891) | 4857891..4858181 | - | 291 | WP_000362050.1 | DNA-binding transcriptional regulator | - |
| DAX98_RS23840 (4858182) | 4858182..4858493 | - | 312 | WP_001159630.1 | cytotoxic translational repressor of toxin-antitoxin stability system | - |
| DAX98_RS23845 (4858711) | 4858711..4859640 | + | 930 | WP_021294279.1 | alpha/beta hydrolase | - |
| DAX98_RS23850 (4859726) | 4859726..4860037 | + | 312 | WP_000558166.1 | type II toxin-antitoxin system HigB family toxin | Toxin |
| DAX98_RS23855 (4860034) | 4860034..4860480 | + | 447 | WP_001259012.1 | type II toxin-antitoxin system HigA family antitoxin | Antitoxin |
| DAX98_RS23860 (4860495) | 4860495..4861436 | - | 942 | WP_001518251.1 | fatty acid biosynthesis protein FabY | - |
| DAX98_RS23865 (4861481) | 4861481..4861918 | - | 438 | WP_001621365.1 | D-aminoacyl-tRNA deacylase | - |
| DAX98_RS23870 (4861915) | 4861915..4862787 | - | 873 | WP_000921423.1 | virulence factor BrkB family protein | - |
| DAX98_RS23875 (4862781) | 4862781..4863380 | - | 600 | WP_000965695.1 | glucose-1-phosphatase | - |
| DAX98_RS23880 (4863571) | 4863571..4864374 | - | 804 | WP_000059693.1 | DeoR/GlpR family DNA-binding transcription regulator | - |
| DAX98_RS23885 (4864408) | 4864408..4865304 | - | 897 | WP_023197766.1 | sugar kinase | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 104 a.a. Molecular weight: 12432.40 Da Isoelectric Point: 9.5334
>T207499 WP_000558166.1 NZ_CP077691:4859726-4860037 [Salmonella enterica subsp. enterica]
VHVISRKPFNEAMLMYPNHELALTELLNVLEKKTFTQPEEMKRYIPSLDNFKYRDKWWVIDVSGNSLRLISYIDFRLHKI
FVKHIVSHAEYDKLTAYYRGNKE
VHVISRKPFNEAMLMYPNHELALTELLNVLEKKTFTQPEEMKRYIPSLDNFKYRDKWWVIDVSGNSLRLISYIDFRLHKI
FVKHIVSHAEYDKLTAYYRGNKE
Download Length: 312 bp
>T207499 NZ_CP103308:c2253621-2253343 [Rhodococcus pyridinivorans]
ATGAGCACTCCGGACCACCCGTATCGGCTGGTGATGGCGAGGTCGGCTGCACGCGCCATGGCGAGGTCGTTGCCGGAGAA
GGTAGCAACTGCGGTATACGAGTTCGTCACAGGACCCCTTCTCGAGAATCCGAAGCGGGTGGGGAAGCCGTTGAATCCGC
CTCTTGCGCCGGCGTACAGCGCCCGGCGAGGTGAATATCGCGTCCTGTATCTGATCGATGATGCGAACCGCACGGTCGAG
GTCACCGCGATTTCGCACCGTGCCGATGCGTATCGATAG
ATGAGCACTCCGGACCACCCGTATCGGCTGGTGATGGCGAGGTCGGCTGCACGCGCCATGGCGAGGTCGTTGCCGGAGAA
GGTAGCAACTGCGGTATACGAGTTCGTCACAGGACCCCTTCTCGAGAATCCGAAGCGGGTGGGGAAGCCGTTGAATCCGC
CTCTTGCGCCGGCGTACAGCGCCCGGCGAGGTGAATATCGCGTCCTGTATCTGATCGATGATGCGAACCGCACGGTCGAG
GTCACCGCGATTTCGCACCGTGCCGATGCGTATCGATAG
Antitoxin
Download Length: 149 a.a. Molecular weight: 16750.08 Da Isoelectric Point: 6.6451
>AT207499 WP_001259012.1 NZ_CP077691:4860034-4860480 [Salmonella enterica subsp. enterica]
MRTHRQMDATSAKKIVDTFSDAVKTVPLMGEDRNDNEYRRALALVEFLVDHDDLENPLFELLCARISEYEKHAPEFKSLN
QHLEKTPPGVSVLRTLMDQYGLKAADLANELGSKSNVSNILNGRRALTVNHIKALTQRFKLPADAFIE
MRTHRQMDATSAKKIVDTFSDAVKTVPLMGEDRNDNEYRRALALVEFLVDHDDLENPLFELLCARISEYEKHAPEFKSLN
QHLEKTPPGVSVLRTLMDQYGLKAADLANELGSKSNVSNILNGRRALTVNHIKALTQRFKLPADAFIE
Download Length: 447 bp
>AT207499 NZ_CP103308:c2253902-2253618 [Rhodococcus pyridinivorans]
ATGACGACTCTTCCTGTTGCCGACGCGCGGGCGCAATTGTCACGACTGGTCGATGAGGCCGAGCGCACACACGAGCGATT
CGAGATCACCCGCAACGGGCACCGCGCCGCGGTGCTTCTCGGTGCCGACGATTACGACGCGATGCAGGAGACGATCGCGG
TGTTGTCGGATACGGATCTGCTGCGGGCGCACGTCGAGGGCCGAACGGAGGTCGAGTCGGGAGACGTCGTCGATGTACAG
GAATTGACGCAGCTGATGCGTGATGCTCGGTCGTCCGAGGAATGA
ATGACGACTCTTCCTGTTGCCGACGCGCGGGCGCAATTGTCACGACTGGTCGATGAGGCCGAGCGCACACACGAGCGATT
CGAGATCACCCGCAACGGGCACCGCGCCGCGGTGCTTCTCGGTGCCGACGATTACGACGCGATGCAGGAGACGATCGCGG
TGTTGTCGGATACGGATCTGCTGCGGGCGCACGTCGAGGGCCGAACGGAGGTCGAGTCGGGAGACGTCGTCGATGTACAG
GAATTGACGCAGCTGATGCGTGATGCTCGGTCGTCCGAGGAATGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|