Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/Txe-RelB
Location 2535956..2536479 Replicon chromosome
Accession NC_003923
Organism Staphylococcus aureus subsp. aureus MW2

Toxin (Protein)


Gene name yoeB Uniprot ID X5DYX7
Locus tag MW_RS12915 Protein ID WP_000074048.1
Coordinates 2535956..2536222 (-) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID W8TQT5
Locus tag MW_RS12920 Protein ID WP_000587616.1
Coordinates 2536222..2536479 (-) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MW_RS12895 (MW2376) 2531262..2532449 - 1188 WP_000026194.1 MFS transporter -
MW_RS12900 (MW2377) 2532845..2533621 - 777 WP_000072145.1 iron export ABC transporter permease subunit FetB -
MW_RS12905 (MW2378) 2533614..2534276 - 663 WP_000923523.1 ATP-binding cassette domain-containing protein -
MW_RS12910 (MW2379) 2534524..2535600 - 1077 WP_001076671.1 M42 family metallopeptidase -
MW_RS12915 (MW2380) 2535956..2536222 - 267 WP_000074048.1 Txe/YoeB family addiction module toxin Toxin
MW_RS12920 (MW2381) 2536222..2536479 - 258 WP_000587616.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
MW_RS12930 (MW2382) 2536838..2537293 + 456 WP_000732082.1 DUF1307 domain-containing protein -
MW_RS12935 (MW2383) 2537461..2539038 - 1578 WP_000143496.1 FMN-binding glutamate synthase family protein -
MW_RS12940 (MW2384) 2539234..2539983 + 750 WP_000072445.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(25-87)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-68)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10648.23 Da        Isoelectric Point: 10.1384

>T20746 WP_000074048.1 NC_003923:c2536222-2535956 [Staphylococcus aureus subsp. aureus MW2]
MSNYTVKIKNSAKSDLKKIKHSYLKKSFLEIVETLKNDPYKITQSFEKLEPKYLERYSRRINHQHRVVYTVDDRNKEVLI
LSAWSHYD

Download         Length: 267 bp

>T20746 NC_003923:c2536222-2535956 [Staphylococcus aureus subsp. aureus MW2]
ATGAGCAATTACACGGTTAAGATTAAAAATTCAGCGAAATCAGATTTAAAGAAAATAAAACATTCTTATTTAAAGAAGTC
ATTTTTAGAAATTGTTGAGACTTTAAAAAATGATCCGTATAAAATAACACAATCTTTTGAAAAATTAGAGCCTAAATATT
TAGAGCGATATTCAAGAAGAATTAACCATCAGCACAGGGTCGTCTATACCGTAGATGATCGAAATAAAGAAGTATTAATA
CTATCGGCATGGTCACATTATGATTAA

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9774.73 Da        Isoelectric Point: 4.1353

>AT20746 WP_000587616.1 NC_003923:c2536479-2536222 [Staphylococcus aureus subsp. aureus MW2]
MIITSPTEARKDFYQLLKNVNNNHEPIYISGNNAENNAVIIGLEDWKSIQETIYLESTGTMDKVREREKDNSGTTNIDDI
DWDNL

Download         Length: 258 bp

>AT20746 NC_003923:c2536479-2536222 [Staphylococcus aureus subsp. aureus MW2]
ATGATTATCACTAGCCCTACAGAAGCGAGAAAAGATTTTTATCAATTACTAAAAAATGTTAATAATAATCACGAACCAAT
TTATATTAGTGGCAATAATGCCGAAAATAATGCTGTGATTATAGGTTTAGAAGATTGGAAAAGTATACAAGAGACAATAT
ATCTTGAATCTACTGGTACAATGGACAAAGTAAGAGAAAGAGAAAAAGATAATAGTGGTACAACAAATATAGATGATATT
GATTGGGATAATCTTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 7V6W
PDB 7V5Y
PDB 7V5Z

Antitoxin

Source ID Structure
PDB 7V6W
PDB 7V5Z
PDB 7V5Y
AlphaFold DB W8TQT5

References