Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | higBA (relBE)/HTH(antitoxin) |
| Location | 239398..240000 | Replicon | chromosome |
| Accession | NZ_CP077680 | ||
| Organism | Salmonella enterica subsp. enterica serovar Kentucky strain YZ20MCS16 | ||
Toxin (Protein)
| Gene name | higB | Uniprot ID | A0A603E470 |
| Locus tag | KTJ81_RS01190 | Protein ID | WP_023138876.1 |
| Coordinates | 239398..239709 (+) | Length | 104 a.a. |
Antitoxin (Protein)
| Gene name | higA | Uniprot ID | - |
| Locus tag | KTJ81_RS01195 | Protein ID | WP_000362052.1 |
| Coordinates | 239710..240000 (+) | Length | 97 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| KTJ81_RS01155 (234511) | 234511..235110 | + | 600 | WP_000965695.1 | glucose-1-phosphatase | - |
| KTJ81_RS01160 (235104) | 235104..235976 | + | 873 | WP_000921423.1 | virulence factor BrkB family protein | - |
| KTJ81_RS01165 (235973) | 235973..236410 | + | 438 | WP_000560969.1 | D-aminoacyl-tRNA deacylase | - |
| KTJ81_RS01170 (236455) | 236455..237396 | + | 942 | WP_001518251.1 | fatty acid biosynthesis protein FabY | - |
| KTJ81_RS01175 (237411) | 237411..237857 | - | 447 | WP_001259011.1 | type II toxin-antitoxin system HigA family antitoxin | - |
| KTJ81_RS01180 (237854) | 237854..238165 | - | 312 | WP_000558166.1 | type II toxin-antitoxin system HigB family toxin | - |
| KTJ81_RS01185 (238251) | 238251..239180 | - | 930 | WP_001127698.1 | alpha/beta hydrolase | - |
| KTJ81_RS01190 (239398) | 239398..239709 | + | 312 | WP_023138876.1 | hypothetical protein | Toxin |
| KTJ81_RS01195 (239710) | 239710..240000 | + | 291 | WP_000362052.1 | DNA-binding transcriptional regulator | Antitoxin |
| KTJ81_RS01200 (240047) | 240047..240976 | - | 930 | WP_000027730.1 | formate dehydrogenase accessory protein FdhE | - |
| KTJ81_RS01205 (240973) | 240973..241608 | - | 636 | WP_000829025.1 | formate dehydrogenase cytochrome b556 subunit | - |
| KTJ81_RS01210 (241605) | 241605..242507 | - | 903 | WP_000331361.1 | formate dehydrogenase subunit beta | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 104 a.a. Molecular weight: 12356.30 Da Isoelectric Point: 9.4460
>T207455 WP_023138876.1 NZ_CP077680:239398-239709 [Salmonella enterica subsp. enterica serovar Kentucky]
MQFIETELFTEDVKKLLDEDEYHKLQVFMAQHPDCGDVIQETGGLRKMRWGSRGKGKRSGVRIIYFHRSQRYEIRLLLIY
QKGIKDDLTPQEKAVLRMLNERW
MQFIETELFTEDVKKLLDEDEYHKLQVFMAQHPDCGDVIQETGGLRKMRWGSRGKGKRSGVRIIYFHRSQRYEIRLLLIY
QKGIKDDLTPQEKAVLRMLNERW
Download Length: 312 bp
>T207455 NZ_CP103290:c342556-341810 [Bacillus atrophaeus]
ATGCTTTTATTCTTTCAGATTATGGTTTGGTGCATAATGGCCGCATTAGGCCTATACGTATATGCGGTGTGGCGGTTTGA
AGCAAAGGTGAAAGAAAAAATGTTTGCGATCCGGAAAACGTGGTATTTGATCTTTGTGATCGGCGCCATGGTATACTGGA
CGTATGACCCCTCTTCCCTTTTCAGGGAATGGACGAATTATTTGATTGTCGCTGTCAGCTTTGCTTTGGTTGACGCCTTT
ATCTTTTTGAGCGCTTACGTAAAGAAACTTGCCGGCAATGAATTAGAAACCGACACACGGGAAATCCTTGAAGAAAACAA
TGAAATGCTCCACGTTTATCTTGATAAATTAAAAACGTACCAATACCTATTGAAAAATGAACCGATCCATGTTTATTATG
GAAGTATAGAAGCATACGCCGAGGGCATCGACAAGCTGCTCAAAACCTATGCCGACAAAATGAACTTAACGGCTTCACTG
TGTGAATATTCGACACAGCTTGAAAAAGACCGCTTAACCGAGCATATGGATGATGCATTTGAGGTGCAGAGCCGGCTGGA
TCGAAAAGATGTATACTATGATCAGCACGGGAAGCTGGCACTCATCCCTTTTACAGTCCAGACACGCAGCTACGTCATCA
AGCTGGCGTCAGACAGCATTGTAACAGAATTTGATTATTTGCTTTTCACGTCATTAACTAGCATTTACGATTTGGTGCTG
CCAATTGAGGAGGAAGGTGACGGATAA
ATGCTTTTATTCTTTCAGATTATGGTTTGGTGCATAATGGCCGCATTAGGCCTATACGTATATGCGGTGTGGCGGTTTGA
AGCAAAGGTGAAAGAAAAAATGTTTGCGATCCGGAAAACGTGGTATTTGATCTTTGTGATCGGCGCCATGGTATACTGGA
CGTATGACCCCTCTTCCCTTTTCAGGGAATGGACGAATTATTTGATTGTCGCTGTCAGCTTTGCTTTGGTTGACGCCTTT
ATCTTTTTGAGCGCTTACGTAAAGAAACTTGCCGGCAATGAATTAGAAACCGACACACGGGAAATCCTTGAAGAAAACAA
TGAAATGCTCCACGTTTATCTTGATAAATTAAAAACGTACCAATACCTATTGAAAAATGAACCGATCCATGTTTATTATG
GAAGTATAGAAGCATACGCCGAGGGCATCGACAAGCTGCTCAAAACCTATGCCGACAAAATGAACTTAACGGCTTCACTG
TGTGAATATTCGACACAGCTTGAAAAAGACCGCTTAACCGAGCATATGGATGATGCATTTGAGGTGCAGAGCCGGCTGGA
TCGAAAAGATGTATACTATGATCAGCACGGGAAGCTGGCACTCATCCCTTTTACAGTCCAGACACGCAGCTACGTCATCA
AGCTGGCGTCAGACAGCATTGTAACAGAATTTGATTATTTGCTTTTCACGTCATTAACTAGCATTTACGATTTGGTGCTG
CCAATTGAGGAGGAAGGTGACGGATAA
Antitoxin
Download Length: 97 a.a. Molecular weight: 10970.65 Da Isoelectric Point: 11.0303
>AT207455 WP_000362052.1 NZ_CP077680:239710-240000 [Salmonella enterica subsp. enterica serovar Kentucky]
MDKVLFERLTQSMSQMNEIIEGTRKPSRTFHIDAMKIKEIRQASGLSQSKFAELISVNVDTLRNWEQGRRSPTGPAKALL
RAIANDPRNVIQALRY
MDKVLFERLTQSMSQMNEIIEGTRKPSRTFHIDAMKIKEIRQASGLSQSKFAELISVNVDTLRNWEQGRRSPTGPAKALL
RAIANDPRNVIQALRY
Download Length: 291 bp
>AT207455 NZ_CP103290:c341810-341640 [Bacillus atrophaeus]
ATGGAACGTGCTTTTCAAAACGATCATTCGCCCCGCGCGGCTAAACCGTTTAAGATATTAAAAAAGAGATCAACCACCAG
CGTCGCAAGCTATCAGGTCAGCCCCCACACGGCAAGAATTTTCAAAGAAAATGAGCGGCTGATTGACGAGTATAAAAGAA
AAAAAGCATGA
ATGGAACGTGCTTTTCAAAACGATCATTCGCCCCGCGCGGCTAAACCGTTTAAGATATTAAAAAAGAGATCAACCACCAG
CGTCGCAAGCTATCAGGTCAGCCCCCACACGGCAAGAATTTTCAAAGAAAATGAGCGGCTGATTGACGAGTATAAAAGAA
AAAAAGCATGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|