Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 3771726..3772314 Replicon chromosome
Accession NZ_CP077679
Organism Stenotrophomonas maltophilia strain Col1

Toxin (Protein)


Gene name graT Uniprot ID -
Locus tag KS456_RS17325 Protein ID WP_049435905.1
Coordinates 3772036..3772314 (-) Length 93 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag KS456_RS17320 Protein ID WP_049435907.1
Coordinates 3771726..3772025 (-) Length 100 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KS456_RS17300 3767163..3768350 + 1188 WP_217014256.1 pyridoxal phosphate-dependent aminotransferase -
KS456_RS17305 3768461..3770557 - 2097 WP_010481373.1 prolyl oligopeptidase family serine peptidase -
KS456_RS17310 3770627..3770953 - 327 WP_071305877.1 hypothetical protein -
KS456_RS17315 3771081..3771683 + 603 WP_010481371.1 lipocalin family protein -
KS456_RS17320 3771726..3772025 - 300 WP_049435907.1 HigA family addiction module antitoxin Antitoxin
KS456_RS17325 3772036..3772314 - 279 WP_049435905.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
KS456_RS17330 3772552..3773241 - 690 WP_010481370.1 methionine ABC transporter permease -
KS456_RS17335 3773238..3774245 - 1008 WP_054172533.1 methionine ABC transporter ATP-binding protein -
KS456_RS17340 3774401..3775297 - 897 WP_049435902.1 DMT family transporter -
KS456_RS17345 3775389..3775871 + 483 WP_006471121.1 YajQ family cyclic di-GMP-binding protein -
KS456_RS17350 3775907..3777004 - 1098 WP_217014258.1 helix-turn-helix domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(27-92)

Antitoxin

Cro/C1-type helix-turn-helix domain

(21-68)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10739.24 Da        Isoelectric Point: 10.4115

>T207453 WP_049435905.1 NZ_CP077679:c3772314-3772036 [Stenotrophomonas maltophilia]
MIRSFRCKQTRALFEGTCPRAWRPIRRAAERKLQLLDSAQTLAFLRSPPGNRLEALSGDRRGQYSLRINDQWRLCFTWTD
NGADAVEIVDYH

Download         Length: 279 bp

>T207453 NZ_CP103288:1220455-1220781 [Pseudarthrobacter sp. NS4]
GTGAATCGAGGCGAGCTGTGGACAGTCTCAGGCGGAATTTATGCACAAAAGCCCCGGCCAGCGCTGATCATCCAGGACGA
CCTGTTTGAGGCGTCGGAGTCAGTCACTCTTTTGCCGCTGACGTCCCAACTGACCGACGCCCCGATATTGAGGTTAACGG
TTGAGCCAGGTGACCTCACAGGACTGGAGCGCGAAAGCCAGATCATGGTGGACAAATTGACCACCGTACGGCGTGCCAAT
CTTGGGCAGCGGGTAGGGCAAGTAGATGCCAAGACGATGGCAGCCGTCGAACAATCCCTTGCCGTCTTCCTGGGGCTGGG
GAGTTGA

Antitoxin


Download         Length: 100 a.a.        Molecular weight: 10893.57 Da        Isoelectric Point: 10.8423

>AT207453 WP_049435907.1 NZ_CP077679:c3772025-3771726 [Stenotrophomonas maltophilia]
MKRPYNGMRAIHPGEVLREEFLIPLGLSVNALARALDVPATRLHAIVHGERGISADTAARLARHFGGDAASWLAMQAAYD
LKTLPTRNEIERRVQPRAA

Download         Length: 300 bp

>AT207453 NZ_CP103288:1220255-1220458 [Pseudarthrobacter sp. NS4]
ATGAGTGTCAGGGACCGCGTTGCACGGCACCGGATTGCTATGCGTGAGCGTGGCCTACGGCAGATTCAGATGTGGGTGCC
GGACATCCGTACAGAGGAGTTCAAGCGTGAAGCGCGGCGGCAGGCACTGGCTGTTGCTGCCGCAGACCGGGCTGCCGACG
ACCAGGACTTTATCGAGGAGATCTCGGAAGACTGGCCGGAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References