Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) SprA2-SprA2AS/-
Location 2504766..2504950 Replicon chromosome
Accession NC_003923
Organism Staphylococcus aureus subsp. aureus MW2

Toxin (Protein)


Gene name SprA2 Uniprot ID A0A2P7CQJ7
Locus tag MW_RS12760 Protein ID WP_000482647.1
Coordinates 2504843..2504950 (-) Length 36 a.a.

Antitoxin (RNA)


Gene name SprA2AS
Locus tag -
Coordinates 2504766..2504826 (+)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MW_RS12735 2500240..2500407 - 168 WP_001793334.1 hypothetical protein -
MW_RS12745 (MW2351) 2500638..2502371 - 1734 WP_000486494.1 ABC transporter ATP-binding protein/permease -
MW_RS12750 (MW2352) 2502396..2504159 - 1764 WP_001064815.1 ABC transporter ATP-binding protein/permease -
- 2504766..2504826 + 61 - - Antitoxin
MW_RS12760 2504843..2504950 - 108 WP_000482647.1 type I toxin-antitoxin system Fst family toxin Toxin
MW_RS12765 (MW2355) 2505084..2505470 - 387 WP_000779360.1 flippase GtxA -
MW_RS12770 (MW2356) 2505728..2506870 + 1143 WP_001176871.1 glycerate kinase -
MW_RS12775 (MW2357) 2506930..2507589 + 660 WP_000831301.1 membrane protein -
MW_RS12780 (MW2358) 2507771..2508982 + 1212 WP_001192075.1 multidrug effflux MFS transporter -
MW_RS12785 (MW2359) 2509105..2509578 - 474 WP_000456497.1 GyrI-like domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.



Sequences

Toxin        


Download         Length: 36 a.a.        Molecular weight: 4012.76 Da        Isoelectric Point: 10.4935

>T20744 WP_000482647.1 NC_003923:c2504950-2504843 [Staphylococcus aureus subsp. aureus MW2]
MFNLLIDIMTSALSGCLVAFFAHWLRTRNNKKGDK

Download         Length: 108 bp

>T20744 NC_003923:c2504950-2504843 [Staphylococcus aureus subsp. aureus MW2]
ATGTTCAATTTATTAATTGACATCATGACTTCAGCTTTAAGCGGCTGTCTTGTTGCGTTTTTTGCACATTGGTTACGAAC
GCGCAACAATAAAAAAGGTGACAAATAA

Antitoxin


Download         Length: 61 bp

>AT20744 NC_003923:2504766-2504826 [Staphylococcus aureus subsp. aureus MW2]
TACATAATAAATTGAACATCTAAATACACCAAATCCCCTCACTACTGCCATAGTGAGGGGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2P7CQJ7

Antitoxin

Download structure file

References