Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | yefM-yoeB (relBE)/Txe-RelB |
| Location | 2479407..2479924 | Replicon | chromosome |
| Accession | NC_003923 | ||
| Organism | Staphylococcus aureus subsp. aureus MW2 | ||
Toxin (Protein)
| Gene name | yoeB | Uniprot ID | T1YC79 |
| Locus tag | MW_RS12605 | Protein ID | WP_000113262.1 |
| Coordinates | 2479407..2479673 (-) | Length | 89 a.a. |
Antitoxin (Protein)
| Gene name | yefM | Uniprot ID | T1YB60 |
| Locus tag | MW_RS12610 | Protein ID | WP_000584499.1 |
| Coordinates | 2479673..2479924 (-) | Length | 84 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| MW_RS12580 (MW2324) | 2474835..2475362 | - | 528 | WP_000973468.1 | GNAT family N-acetyltransferase | - |
| MW_RS12585 (MW2325) | 2475606..2476430 | - | 825 | WP_000572040.1 | formate/nitrite transporter family protein | - |
| MW_RS12590 (MW2326) | 2476647..2476829 | - | 183 | WP_000230294.1 | hypothetical protein | - |
| MW_RS12595 (MW2327) | 2476913..2477380 | - | 468 | WP_000153344.1 | SRPBCC domain-containing protein | - |
| MW_RS12600 (MW2328) | 2477566..2479113 | - | 1548 | WP_000727756.1 | zinc ABC transporter substrate-binding lipoprotein AdcA | - |
| MW_RS12605 (MW2329) | 2479407..2479673 | - | 267 | WP_000113262.1 | Txe/YoeB family addiction module toxin | Toxin |
| MW_RS12610 (MW2330) | 2479673..2479924 | - | 252 | WP_000584499.1 | type II toxin-antitoxin system Phd/YefM family antitoxin | Antitoxin |
| MW_RS12615 | 2480089..2480190 | - | 102 | Protein_2380 | hypothetical protein | - |
| MW_RS12620 (MW2331) | 2480197..2480796 | - | 600 | WP_000162810.1 | DsbA family protein | - |
| MW_RS12625 (MW2332) | 2480815..2481177 | - | 363 | WP_000819843.1 | DUF4467 domain-containing protein | - |
| MW_RS12630 (MW2333) | 2481433..2482683 | + | 1251 | WP_001012222.1 | FemA/FemB family glycyltransferase FmhA | - |
| MW_RS12635 (MW2334) | 2482780..2483511 | - | 732 | WP_000615458.1 | amino acid ABC transporter ATP-binding protein | - |
| MW_RS12640 | 2483508..2484227 | - | 720 | WP_000479576.1 | amino acid ABC transporter permease | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 89 a.a. Molecular weight: 10437.95 Da Isoelectric Point: 9.9143
>T20743 WP_000113262.1 NC_003923:c2479673-2479407 [Staphylococcus aureus subsp. aureus MW2]
MARLNITFSPQAFEDYKYFQQNDKKMVKKINELLKSIDRNGALEGIGKPEKLKSNLTGYYSRRINHEHRLVYTVDDNHIK
IASCKYHY
MARLNITFSPQAFEDYKYFQQNDKKMVKKINELLKSIDRNGALEGIGKPEKLKSNLTGYYSRRINHEHRLVYTVDDNHIK
IASCKYHY
Download Length: 267 bp
>T20743 NC_003923:c2479673-2479407 [Staphylococcus aureus subsp. aureus MW2]
ATGGCTAGGTTAAATATTACGTTTTCGCCTCAAGCCTTTGAAGATTATAAGTATTTTCAGCAGAACGATAAAAAAATGGT
GAAGAAAATTAATGAGTTACTTAAAAGTATTGACAGAAATGGTGCATTGGAAGGTATAGGTAAGCCTGAAAAGTTAAAAT
CGAATCTGACTGGGTATTATAGTAGACGTATCAATCACGAACATAGATTGGTTTATACAGTAGATGACAATCATATAAAA
ATAGCATCATGTAAATACCATTATTAA
ATGGCTAGGTTAAATATTACGTTTTCGCCTCAAGCCTTTGAAGATTATAAGTATTTTCAGCAGAACGATAAAAAAATGGT
GAAGAAAATTAATGAGTTACTTAAAAGTATTGACAGAAATGGTGCATTGGAAGGTATAGGTAAGCCTGAAAAGTTAAAAT
CGAATCTGACTGGGTATTATAGTAGACGTATCAATCACGAACATAGATTGGTTTATACAGTAGATGACAATCATATAAAA
ATAGCATCATGTAAATACCATTATTAA
Antitoxin
Download Length: 84 a.a. Molecular weight: 9433.60 Da Isoelectric Point: 4.3407
>AT20743 WP_000584499.1 NC_003923:c2479924-2479673 [Staphylococcus aureus subsp. aureus MW2]
MIIKNYSYARQNLKALMTKVNDDSDMVTVTSTDDKNVVIMSESDYNSMMETLYLQQNPNNAEHLAQSIADLERGKTITKD
IDV
MIIKNYSYARQNLKALMTKVNDDSDMVTVTSTDDKNVVIMSESDYNSMMETLYLQQNPNNAEHLAQSIADLERGKTITKD
IDV
Download Length: 252 bp
>AT20743 NC_003923:c2479924-2479673 [Staphylococcus aureus subsp. aureus MW2]
ATGATTATTAAAAATTATTCATACGCTCGACAGAATTTAAAGGCACTTATGACAAAAGTAAATGATGATAGTGATATGGT
AACTGTAACATCTACTGATGATAAAAACGTAGTAATCATGTCAGAATCAGATTATAACTCCATGATGGAAACACTTTACC
TCCAACAGAACCCAAATAATGCTGAACACTTAGCTCAATCAATTGCAGATCTAGAACGTGGGAAAACTATAACGAAAGAT
ATAGATGTATAA
ATGATTATTAAAAATTATTCATACGCTCGACAGAATTTAAAGGCACTTATGACAAAAGTAAATGATGATAGTGATATGGT
AACTGTAACATCTACTGATGATAAAAACGTAGTAATCATGTCAGAATCAGATTATAACTCCATGATGGAAACACTTTACC
TCCAACAGAACCCAAATAATGCTGAACACTTAGCTCAATCAATTGCAGATCTAGAACGTGGGAAAACTATAACGAAAGAT
ATAGATGTATAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|