Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | higBA (relBE)/HigB-HigA |
| Location | 4498231..4498985 | Replicon | chromosome |
| Accession | NZ_CP077670 | ||
| Organism | Salmonella enterica strain S90 | ||
Toxin (Protein)
| Gene name | higB | Uniprot ID | A0A4Y6MJG6 |
| Locus tag | KTP13_RS21720 | Protein ID | WP_000558165.1 |
| Coordinates | 4498231..4498542 (+) | Length | 104 a.a. |
Antitoxin (Protein)
| Gene name | higA | Uniprot ID | - |
| Locus tag | KTP13_RS21725 | Protein ID | WP_001259009.1 |
| Coordinates | 4498539..4498985 (+) | Length | 149 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| KTP13_RS21690 (4493897) | 4493897..4494799 | + | 903 | WP_051129234.1 | formate dehydrogenase subunit beta | - |
| KTP13_RS21695 (4494796) | 4494796..4495431 | + | 636 | WP_000829028.1 | formate dehydrogenase cytochrome b556 subunit | - |
| KTP13_RS21700 (4495428) | 4495428..4496357 | + | 930 | WP_000027730.1 | formate dehydrogenase accessory protein FdhE | - |
| KTP13_RS21705 (4496395) | 4496395..4496769 | - | 375 | WP_000238494.1 | type II toxin-antitoxin system VapC family toxin | - |
| KTP13_RS21710 (4496769) | 4496769..4497011 | - | 243 | WP_001523745.1 | CopG family transcriptional regulator | - |
| KTP13_RS21715 (4497216) | 4497216..4498145 | + | 930 | WP_001162861.1 | alpha/beta hydrolase | - |
| KTP13_RS21720 (4498231) | 4498231..4498542 | + | 312 | WP_000558165.1 | type II toxin-antitoxin system HigB family toxin | Toxin |
| KTP13_RS21725 (4498539) | 4498539..4498985 | + | 447 | WP_001259009.1 | type II toxin-antitoxin system HigA family antitoxin | Antitoxin |
| KTP13_RS21730 (4499000) | 4499000..4499941 | - | 942 | WP_001518251.1 | fatty acid biosynthesis protein FabY | - |
| KTP13_RS21735 (4499986) | 4499986..4500423 | - | 438 | WP_000560969.1 | D-aminoacyl-tRNA deacylase | - |
| KTP13_RS21740 (4500420) | 4500420..4501292 | - | 873 | WP_000921423.1 | virulence factor BrkB family protein | - |
| KTP13_RS21745 (4501286) | 4501286..4501885 | - | 600 | WP_023227076.1 | glucose-1-phosphatase | - |
| KTP13_RS21750 (4502076) | 4502076..4502879 | - | 804 | WP_000059689.1 | DeoR family transcriptional regulator | - |
| KTP13_RS21755 (4502913) | 4502913..4503809 | - | 897 | WP_023227075.1 | sugar kinase | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 104 a.a. Molecular weight: 12433.34 Da Isoelectric Point: 8.4020
>T207420 WP_000558165.1 NZ_CP077670:4498231-4498542 [Salmonella enterica]
VHVISRKPFNEAMLMYPNHELALTELLNVLEKKTFTQPEEMKRYIPSLDNFKYRDKWWVIDVSGNSLRLISYIDFRLHKI
FVKHIVSHAEYDKLTAYYRGNEE
VHVISRKPFNEAMLMYPNHELALTELLNVLEKKTFTQPEEMKRYIPSLDNFKYRDKWWVIDVSGNSLRLISYIDFRLHKI
FVKHIVSHAEYDKLTAYYRGNEE
Download Length: 312 bp
>T207420 NZ_CP102987:c5204763-5204380 [Klebsiella pneumoniae]
ATGACCTCCGGATCTGCGCTTTTTGATACCAATATTCTTATTGATTTATTTAGCGGGCGTCGCGAAGCCAAACAGGCGCT
GGAGGCCTGGCCACCGCAGAATGCGATCAGTCTGATTACCTGGATGGAGGTGATGGTTGGCGCTAAAAAATATCACCAGG
AGCAGCGCACGCGAATGGCGCTGAGCACCTTTAATATCATTAACATCTCACAGGATATTGCAGAGCGAAGCGTTGCGCTG
CGGCAGGAGTATAAGCTTAAGCTGCCGGATGCCATCATTCTGGCGACGGCGCAACTCCATCGTCTGGAACTAATTACGCG
GAATACGAAGGATTTTGCCGGTATTCCTGGCGTAGTCACGCCGTACGAAATCCACCCTGAATAA
ATGACCTCCGGATCTGCGCTTTTTGATACCAATATTCTTATTGATTTATTTAGCGGGCGTCGCGAAGCCAAACAGGCGCT
GGAGGCCTGGCCACCGCAGAATGCGATCAGTCTGATTACCTGGATGGAGGTGATGGTTGGCGCTAAAAAATATCACCAGG
AGCAGCGCACGCGAATGGCGCTGAGCACCTTTAATATCATTAACATCTCACAGGATATTGCAGAGCGAAGCGTTGCGCTG
CGGCAGGAGTATAAGCTTAAGCTGCCGGATGCCATCATTCTGGCGACGGCGCAACTCCATCGTCTGGAACTAATTACGCG
GAATACGAAGGATTTTGCCGGTATTCCTGGCGTAGTCACGCCGTACGAAATCCACCCTGAATAA
Antitoxin
Download Length: 149 a.a. Molecular weight: 16720.06 Da Isoelectric Point: 6.6451
>AT207420 WP_001259009.1 NZ_CP077670:4498539-4498985 [Salmonella enterica]
MRTHRQMDATSAKKIVDTFSDAVKSVPLMGEDRNDNEYRRALALVEFLVDHDDLENPLFELLCARISEYEKHAPEFKALN
QHLEKTPPGVSVLRTLMDQYGLKAADLANELGSKSNVSNILNGRRALTVNHIKALTQRFKLPADAFIE
MRTHRQMDATSAKKIVDTFSDAVKSVPLMGEDRNDNEYRRALALVEFLVDHDDLENPLFELLCARISEYEKHAPEFKALN
QHLEKTPPGVSVLRTLMDQYGLKAADLANELGSKSNVSNILNGRRALTVNHIKALTQRFKLPADAFIE
Download Length: 447 bp
>AT207420 NZ_CP102987:c5205005-5204763 [Klebsiella pneumoniae]
ATGATGGCTGAAAGGGATATGGGCAGAATTCTTCTCGATTTATCAGACGATGTCATTCAACGTCTCGATGACCTCAAAGT
GCAGCGTAACATTCCGCGAGCGGAACTGTTACGTGAAGCGGTTGAACAATATCTGGAGAAACAAGATCGAGCTAAAGATA
CCATCTCCAGTGCGCTGGGTCTGTGGCAAGACTGCGAAGAAGACGGCATGGAATATCAACGTCAGCTACGCAAGGAGTGG
TAA
ATGATGGCTGAAAGGGATATGGGCAGAATTCTTCTCGATTTATCAGACGATGTCATTCAACGTCTCGATGACCTCAAAGT
GCAGCGTAACATTCCGCGAGCGGAACTGTTACGTGAAGCGGTTGAACAATATCTGGAGAAACAAGATCGAGCTAAAGATA
CCATCTCCAGTGCGCTGGGTCTGTGGCAAGACTGCGAAGAAGACGGCATGGAATATCAACGTCAGCTACGCAAGGAGTGG
TAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|