Detailed information of TA system TA207399

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): higBA (relBE)/HTH(antitoxin)
• Location: 4757442..4758044
• Replicon: chromosome
• Accession: NZ_CP077668
• Organism: Salmonella enterica strain SP

Toxin (Protein)

• Gene name: higB
• Uniprot ID: C0Q3J8
• Locus tag: KTP12_RS23395
• Protein ID: WP_001159630.1
• Coordinates: 4757733..4758044 (-)
• Length: 104 a.a.

Antitoxin (Protein)

• Gene name: higA
• Uniprot ID: -
• Locus tag: KTP12_RS23390
• Protein ID: WP_000362050.1
• Coordinates: 4757442..4757732 (-)
• Length: 97 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KTP12_RS23375 (4754935)	4754935..4755837	+	903	WP_022742856.1	formate dehydrogenase subunit beta	-
KTP12_RS23380 (4755834)	4755834..4756469	+	636	WP_000829025.1	formate dehydrogenase cytochrome b556 subunit	-
KTP12_RS23385 (4756466)	4756466..4757395	+	930	WP_000027730.1	formate dehydrogenase accessory protein FdhE	-
KTP12_RS23390 (4757442)	4757442..4757732	-	291	WP_000362050.1	DNA-binding transcriptional regulator	Antitoxin
KTP12_RS23395 (4757733)	4757733..4758044	-	312	WP_001159630.1	cytotoxic translational repressor of toxin-antitoxin stability system	Toxin
KTP12_RS23400 (4758262)	4758262..4759191	+	930	WP_001127703.1	alpha/beta hydrolase	-
KTP12_RS23405 (4759277)	4759277..4759588	+	312	WP_000558166.1	type II toxin-antitoxin system HigB family toxin	-
KTP12_RS23410 (4759585)	4759585..4760031	+	447	WP_001259011.1	type II toxin-antitoxin system HigA family antitoxin	-
KTP12_RS23415 (4760046)	4760046..4760987	-	942	WP_001518251.1	fatty acid biosynthesis protein FabY	-
KTP12_RS23420 (4761032)	4761032..4761469	-	438	WP_000560974.1	D-aminoacyl-tRNA deacylase	-
KTP12_RS23425 (4761466)	4761466..4762338	-	873	WP_000921427.1	virulence factor BrkB family protein	-
KTP12_RS23430 (4762332)	4762332..4762931	-	600	WP_000965695.1	glucose-1-phosphatase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• Cro/C1-type helix-turn-helix domain (36-85)

Sequences

Toxin

Protein

• Length: 104 a.a.
• Molecular weight: 12326.27 Da
• Isoelectric Point: 9.4460

>T207399 WP_001159630.1 NZ_CP077668:c4758044-4757733 [Salmonella enterica]
MQFIETELFTEDVKKLLDDDEYHKLQVFMAQHPDCGDVIQETGGLRKMRWGARGKGKRSGVRIIYFHRSQRYEIRLLLIY
QKGIKDDLTPQEKAVLRMLNERW

Nucleotide

• Length: 312 bp

>T207399 NZ_CP102977:c818116-817928 [Staphylococcus aureus]
ATGTCTTTACATTTTGCAATTCTGTTTTGGCTAGCATTAATTTTCTTAGTTGCCGCTACGTTTATACTCGTATTAATGAA
AAAAACTGGCAAAGAATCTAAAAAAGAGTCCTATTTAAGTTTCACTGTCATTCTCTATATTTTTGGATTCGCTATATTAA
TATACACATTTATATTTGGTGTGCTATAA

Antitoxin

Protein

• Length: 97 a.a.
• Molecular weight: 10971.59 Da
• Isoelectric Point: 10.6525

>AT207399 WP_000362050.1 NZ_CP077668:c4757732-4757442 [Salmonella enterica]
MDKVLFERLTQSMSQMNEIIEGTREPSRTFHIDAMKIKEIRQASGLSQSKFAELISVNVDTLRNWEQGRRSPTGPAKALL
RAIANDPRNVIQALRY

Nucleotide

• Length: 291 bp

>AT207399 NZ_CP102977:c818405-818145 [Staphylococcus aureus]
ATGAATAACATTTTGTTAAATGCTATCAATATAGTTATTACTACCACTTTTGTTATCTTTAATATTTTAATCACATATAA
TAAAGATTTAGATGATTTATGTTGGCTCCTGCCTGGTATTATCATTTGTGGTGTGATACTCATCGTATCCTTTACCATTG
CAATGATAACTAAAAACTGGTTAAGTGAAATATTATTTTTTATAAATATCGTACTCGTTCTCTATTACATTTATCCTATT
TTTTATAGTTTTATAGGTTAA

Structures

Toxin

• AlphaFold DB: A0A0R9NS64