207391

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) stbDE/ParE-YafN
Location 2533751..2534273 Replicon chromosome
Accession NZ_CP077668
Organism Salmonella enterica strain SP

Toxin (Protein)


Gene name stbE Uniprot ID B5F5Y5
Locus tag KTP12_RS12545 Protein ID WP_000221343.1
Coordinates 2533989..2534273 (+) Length 95 a.a.

Antitoxin (Protein)


Gene name stbD Uniprot ID V1H457
Locus tag KTP12_RS12540 Protein ID WP_000885424.1
Coordinates 2533751..2533999 (+) Length 83 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KTP12_RS12510 (2528901) 2528901..2529581 - 681 Protein_2451 substrate-binding domain-containing protein -
KTP12_RS12515 (2529580) 2529580..2530503 + 924 Protein_2452 hypothetical protein -
KTP12_RS12520 (2531311) 2531311..2532025 + 715 Protein_2453 helix-turn-helix domain-containing protein -
KTP12_RS12525 (2532071) 2532071..2532919 - 849 Protein_2454 hypothetical protein -
KTP12_RS12530 (2533062) 2533062..2533394 - 333 WP_022742691.1 DUF1493 family protein -
KTP12_RS12535 (2533384) 2533384..2533599 - 216 WP_000206207.1 hypothetical protein -
KTP12_RS12540 (2533751) 2533751..2533999 + 249 WP_000885424.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
KTP12_RS12545 (2533989) 2533989..2534273 + 285 WP_000221343.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
KTP12_RS12550 (2534444) 2534444..2534833 + 390 WP_000194089.1 RidA family protein -
KTP12_RS12555 (2534885) 2534885..2535964 - 1080 WP_000954688.1 S-adenosylmethionine:tRNA ribosyltransferase-isomerase -
KTP12_RS12560 (2536157) 2536157..2536645 - 489 WP_001293638.1 MarR family winged helix-turn-helix transcriptional regulator -
KTP12_RS12565 (2536690) 2536690..2538198 + 1509 WP_000199411.1 FAD-dependent oxidoreductase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - - 2529631..2541055 11424


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-84)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11075.85 Da        Isoelectric Point: 10.6500

>T207391 WP_000221343.1 NZ_CP077668:2533989-2534273 [Salmonella enterica]
MTYKLAFNESALKEWKKLGHTIQEQFKKKLRERLENPRVPASQLHGRKDQYKIKLRGAGYRLVYSVEDEIITVTVIGVGK
RENDAVYKMTRHRS

Download         Length: 285 bp

>T207391 NZ_CP102974:c2403648-2403382 [Staphylococcus aureus]
ATGGCTAGGTTAAATATTACGTTTTCGCCTCAAGCCTTTGAAGATTATAAGTATTTTCAGCAGAACGATAAAAAAATGGT
GAAGAAGATTAATGAGTTACTTAAAAGTATTGACAGAAATGGTGCATTGGAAGGTATAGGTAAGCCTGAAAAGTTAAAAT
CGAATCTGACTGGGTATTATAGTAGACGTATCAATCACGAACATAGATTGGTTTATACAGTAGATGACAATCATATAAAA
ATAGCATCATGTAAATACCATTATTAA

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 9090.32 Da        Isoelectric Point: 3.9820

>AT207391 WP_000885424.1 NZ_CP077668:2533751-2533999 [Salmonella enterica]
MAFQILTTTAASITELKRDPMGTFNAGDGAPVAILNRNEPAFYCVPPALYAHLMDILEDEELGRIIDERANERVIEVNID
DL

Download         Length: 249 bp

>AT207391 NZ_CP102974:c2403899-2403648 [Staphylococcus aureus]
ATGATTATTAAAAATTATTCATACGCTCGACAGAATTTAAAGGCACTTATGACAAAAGTAAATGATGATAGTGATATGGT
AACTGTAACATCTACTGATGATAAAAACGTAGTAATCATGTCAGAATCAGATTATAACTCCATGATGGAAACACTTTACC
TCCAACAGAATCCAAATAATGCTGAACACTTAGCTCAATCAATTGCAGATCTAGAACGTGGGAAAACTATAACGAAAGAT
ATAGATGTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A5H5JSW4

Antitoxin

Source ID Structure
AlphaFold DB A0A5I0WPN5

References