Detailed information of TA system TA207374

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): higBA (relBE)/HigB-HigA
• Location: 4641309..4642063
• Replicon: chromosome
• Accession: NZ_CP077662
• Organism: Salmonella enterica strain S146

Toxin (Protein)

• Gene name: higB
• Uniprot ID: A0A3V4SQJ3
• Locus tag: KTP10_RS22360
• Protein ID: WP_000558164.1
• Coordinates: 4641309..4641620 (+)
• Length: 104 a.a.

Antitoxin (Protein)

• Gene name: higA
• Uniprot ID: -
• Locus tag: KTP10_RS22365
• Protein ID: WP_001259011.1
• Coordinates: 4641617..4642063 (+)
• Length: 149 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KTP10_RS22330 (4636967)	4636967..4637869	+	903	WP_000331361.1	formate dehydrogenase subunit beta	-
KTP10_RS22335 (4637866)	4637866..4638501	+	636	WP_000829025.1	formate dehydrogenase cytochrome b556 subunit	-
KTP10_RS22340 (4638498)	4638498..4639427	+	930	WP_000027730.1	formate dehydrogenase accessory protein FdhE	-
KTP10_RS22345 (4639474)	4639474..4639764	-	291	WP_000362050.1	DNA-binding transcriptional regulator	-
KTP10_RS22350 (4639765)	4639765..4640076	-	312	WP_023232499.1	hypothetical protein	-
KTP10_RS22355 (4640294)	4640294..4641223	+	930	WP_023232500.1	alpha/beta hydrolase	-
KTP10_RS22360 (4641309)	4641309..4641620	+	312	WP_000558164.1	type II toxin-antitoxin system HigB family toxin	Toxin
KTP10_RS22365 (4641617)	4641617..4642063	+	447	WP_001259011.1	type II toxin-antitoxin system HigA family antitoxin	Antitoxin
KTP10_RS22370 (4642078)	4642078..4643019	-	942	WP_001518251.1	fatty acid biosynthesis protein FabY	-
KTP10_RS22375 (4643064)	4643064..4643501	-	438	WP_000560969.1	D-aminoacyl-tRNA deacylase	-
KTP10_RS22380 (4643498)	4643498..4644367	-	870	WP_023203606.1	virulence factor BrkB family protein	-
KTP10_RS22385 (4644361)	4644361..4644960	-	600	WP_000965695.1	glucose-1-phosphatase	-
KTP10_RS22390 (4645151)	4645151..4645954	-	804	WP_000059693.1	DeoR/GlpR family DNA-binding transcription regulator	-
KTP10_RS22395 (4645988)	4645988..4646884	-	897	WP_001520529.1	sugar kinase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, mRNA interferase HigB (21-93)

Antitoxin

• Cro/C1-type helix-turn-helix domain (93-146)

Sequences

Toxin

Protein

• Length: 104 a.a.
• Molecular weight: 12404.39 Da
• Isoelectric Point: 9.5206

>T207374 WP_000558164.1 NZ_CP077662:4641309-4641620 [Salmonella enterica]
VHVISRKPFNEAMLMYPNHELALTELLNVLEKKTFTQPEEMKRYIPSLDNFKYRDKWWVIDVSGNSLKLISYIDFRLHKI
FVKHIVSHAEYDKLTAYYRGNKE

Nucleotide

• Length: 312 bp

>T207374 NZ_CP102970:c2514501-2514235 [Staphylococcus aureus]
ATGAGCAATTACACGGTTAAGATTAAAAATTCAGCGAAATCAGATTTAAGGAAAATAAAACATCCTTATTTAAAGAAGAC
ATTTATAGAAATTGTTGAGACTTTAAAAAATGATCCTTATAAAATAACACAATCCTTTGAAAAATTAGAACCTAAATATT
TAGAGCGATATTCAAGAAGAATTAACCTTCAGCACAGGGTCGTCTATACCATAGATGATCGAAATAAAGTAGTATTAATA
CTATCGGCATGGTCACATTATGATTAA

Antitoxin

Protein

• Length: 149 a.a.
• Molecular weight: 16734.08 Da
• Isoelectric Point: 6.6451

>AT207374 WP_001259011.1 NZ_CP077662:4641617-4642063 [Salmonella enterica]
MRTHRQMDATSAKKIVDTFSDAVKTVPLMGEDRNDNEYRRALALVEFLVDHDDLENPLFELLCARISEYEKHAPEFKALN
QHLEKTPPGVSVLRTLMDQYGLKAADLANELGSKSNVSNILNGRRALTVNHIKALTQRFKLPADAFIE

Nucleotide

• Length: 447 bp

>AT207374 NZ_CP102970:c2514758-2514501 [Staphylococcus aureus]
ATGATTATCACTAGCCCTACAGAAGCGAGAAAAGATTTTTATCAATTACTAAAAAATGTTAATAATAATCACGAACCAAT
TTATATTAGTGGCAATAATGCCGAAAATAATGCTGTGATTATAGGTTTAGAAGATTGGAAAAGTATACAAGAGACAATAT
ATCTTGAATCTACTGGTACAATGGACAAAGTAAGAGAAAGAGAAAAGGATAGTAGTGGTACAACAAATATAGATGATATT
GATTGGGATAATCTTTAA

Structures

Toxin

• AlphaFold DB: A0A3V4SQJ3