Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) DinJ-YafQ (relBE)/YafQ-RelB
Location 351211..351749 Replicon chromosome
Accession NZ_CP077662
Organism Salmonella enterica strain S146

Toxin (Protein)


Gene name yafQ Uniprot ID A0A3V8R2L4
Locus tag KTP10_RS01565 Protein ID WP_023231798.1
Coordinates 351474..351749 (+) Length 92 a.a.

Antitoxin (Protein)


Gene name dinJ Uniprot ID A0A7U1KUN1
Locus tag KTP10_RS01560 Protein ID WP_000729714.1
Coordinates 351211..351471 (+) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KTP10_RS01545 (346964) 346964..348517 + 1554 WP_023231801.1 TROVE domain-containing protein -
KTP10_RS01550 (348865) 348865..350079 + 1215 WP_052895236.1 RNA-splicing ligase RtcB -
KTP10_RS01555 (350083) 350083..351102 + 1020 WP_023231799.1 RNA 3'-terminal phosphate cyclase -
KTP10_RS01560 (351211) 351211..351471 + 261 WP_000729714.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
KTP10_RS01565 (351474) 351474..351749 + 276 WP_023231798.1 type II toxin-antitoxin system YafQ family toxin Toxin
KTP10_RS01570 (351837) 351837..354542 - 2706 WP_000907030.1 HTH-type transcriptional regulator MalT -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, YafQ-like toxin

(4-91)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(4-84)


Sequences

Toxin        


Download         Length: 92 a.a.        Molecular weight: 10645.22 Da        Isoelectric Point: 8.8623

>T207354 WP_023231798.1 NZ_CP077662:351474-351749 [Salmonella enterica]
MGQREIEYSGQFQKDVKRAQKRHKDVGKLKTLMTLLIHHPFPLPAIYKDYPLQGSYSGYRDAHIGPDWILIDKITDECLR
FERTGTHADLF

Download         Length: 276 bp

>T207354 NZ_CP102966:c2084644-2084435 [Staphylococcus aureus]
ATGATACATCAAAATACGATTTACACAGCGGGAATTGAAACAGAAGAACAAGTAAGTCAATTGACAGAACGCATTTCAAA
TATGATAGGTGTTCATCAAGTGAATATTAATATAATAGATGGTCAAGTAACTGTATCGTATGAGACACCAGCAAATTTGA
ATAGTATTGAAAAAGAAATCTATGATGAAGGATACAAAATTGTATTTTAG

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9445.82 Da        Isoelectric Point: 4.6028

>AT207354 WP_000729714.1 NZ_CP077662:351211-351471 [Salmonella enterica]
MAANALVRARIDETLKNQAADVLAEMGLTISDLIRITLTKVAREKALPFDLRIPNELTSRTIENSEAGVDIHKAKDADDL
FDQLGI

Download         Length: 261 bp

>AT207354 NZ_CP102966:c2084949-2084656 [Staphylococcus aureus]
ATGACTGAACAAGATAATGCACATCATTCTGAACAAATAAAAACGAATCTTAAATCACGTTTAAATCGAATTGAAGGACA
AGTGAGAGCGATTAATCGCATGATTGAAGAAGATGTCTATTGTGATGATGTCCTTACACAAATAAGAGCGACACGTTCGG
CGTTAAACAGTGTTGCGATAAAGTTATTAGAACAACATATGAAAAGTTGTATTATGAATAAAGTTAATCAAGGTGCTCAG
GAAGAGGCAATGGAAGAGTTATTAGTGACTTTTCAAAAATTGATTAAAGACTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3V8R2L4

Antitoxin

Source ID Structure
AlphaFold DB A0A7U1KUN1

References