Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 225312..225969 Replicon chromosome
Accession NZ_CP077661
Organism Enterobacter cloacae complex sp. ECL112

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag KQQ05_RS01085 Protein ID WP_032609983.1
Coordinates 225312..225611 (+) Length 100 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag KQQ05_RS01090 Protein ID WP_032609984.1
Coordinates 225622..225969 (+) Length 116 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KQQ05_RS01070 220985..221692 + 708 Protein_204 TolC family protein -
KQQ05_RS01075 221689..223881 + 2193 WP_032609980.1 type I secretion system permease/ATPase -
KQQ05_RS01080 223862..225061 + 1200 WP_032609982.1 HlyD family efflux transporter periplasmic adaptor subunit -
KQQ05_RS01085 225312..225611 + 300 WP_032609983.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
KQQ05_RS01090 225622..225969 + 348 WP_032609984.1 HigA family addiction module antitoxin Antitoxin
KQQ05_RS01095 226045..227226 - 1182 WP_023314694.1 PLP-dependent aminotransferase family protein -
KQQ05_RS01100 227247..228134 - 888 WP_022651703.1 LysR family transcriptional regulator -
KQQ05_RS01105 228232..228834 + 603 WP_022651704.1 short chain dehydrogenase -
KQQ05_RS01110 228831..229562 - 732 WP_042863460.1 class I SAM-dependent methyltransferase -
KQQ05_RS01115 229637..230635 - 999 WP_022651706.1 transketolase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 207146..229562 22416


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(1-95)

Antitoxin

Toxin-antitoxin system, antidote protein, HigA

(6-103)


Sequences

Toxin        


Download         Length: 100 a.a.        Molecular weight: 11610.24 Da        Isoelectric Point: 9.6776

>T207338 WP_032609983.1 NZ_CP077661:225312-225611 [Enterobacter cloacae complex sp. ECL112]
MINHFRDQWLEDFFLYGRSSNVIPLNLETALARKLDIINAAMSHLDLRSPPGNIYEALSPTLKGYSSIRVNRQYRLVFRW
SEGKADDLYLSPHKYTQHK

Download         Length: 300 bp

>T207338 NZ_CP102961:c2458413-2458147 [Staphylococcus aureus]
ATGGCTAGGTTAAATATTACGTTTTCGCCTCAAGCCTTTGAAGATTATAAGTATTTTCAGCAGAACGATAAAAAAATGGT
GAAGAAGATTAATGAGTTACTTAAAAGTATTGACAGAAATGGTGCATTGGAAGGTATAGGTAAGCCTGAAAAGTTAAAAT
CGAATCTGACTGGGTATTATAGTAGACGTATCAATCACGAACATAGATTGGTTTATACAGTAGATGACAATCATATAAAA
ATAGCATCATGTAAATACCATTATTAA

Antitoxin


Download         Length: 116 a.a.        Molecular weight: 13094.06 Da        Isoelectric Point: 9.5932

>AT207338 WP_032609984.1 NZ_CP077661:225622-225969 [Enterobacter cloacae complex sp. ECL112]
MTLQQALRKPTTPGEVLQYEYLEPLNLKINDLAEVLNVHRNTVSALVNNNRKLTADMAIKLAKAFNTTIEFWLNLQLNVD
IWETQSNSRTQEELSRIKTVAEVMAKRKSGKPDVA

Download         Length: 348 bp

>AT207338 NZ_CP102961:c2458664-2458413 [Staphylococcus aureus]
ATGATTATTAAAAATTATTCATACGCTCGACAGAATTTAAAGGCACTTATGACAAAAGTAAATGATGATAGTGATATGGT
AACTGTAACATCTACTGATGATAAAAACGTAGTAATCATGTCAGAATCAGATTATAACTCCATGATGGAAACACTTTACC
TCCAACAGAATCCAAATAATGCTGAACACTTAGCTCAATCAATTGCAGATCTAGAACGTGGGAAAACTATAACGAAAGAT
ATAGATGTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References