Detailed information of TA system TA207305

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): higBA (relBE)/COG4683-HTH_37
• Location: 4099082..4099848
• Replicon: chromosome
• Accession: NZ_CP077658
• Organism: Streptomyces sp. GMY02

Toxin (Protein)

• Gene name: HigB2
• Uniprot ID: -
• Locus tag: KQY30_RS17130
• Protein ID: WP_254407181.1
• Coordinates: 4099468..4099848 (-)
• Length: 127 a.a.

Antitoxin (Protein)

• Gene name: higA
• Uniprot ID: -
• Locus tag: KQY30_RS17125
• Protein ID: WP_217307576.1
• Coordinates: 4099082..4099411 (-)
• Length: 110 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KQY30_RS17115 (KQY30_17115)	4095458..4097755	+	2298	WP_217307574.1	SpoIIE family protein phosphatase	-
KQY30_RS17120 (KQY30_17120)	4097955..4098992	-	1038	WP_217307575.1	AI-2E family transporter	-
KQY30_RS17125 (KQY30_17125)	4099082..4099411	-	330	WP_217307576.1	XRE family transcriptional regulator	Antitoxin
KQY30_RS17130 (KQY30_17130)	4099468..4099848	-	381	WP_254407181.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
KQY30_RS17135 (KQY30_17135)	4100015..4100968	-	954	WP_217307577.1	pirin family protein	-
KQY30_RS17140 (KQY30_17140)	4101172..4101678	-	507	WP_217307578.1	SseB family protein	-
KQY30_RS17145 (KQY30_17145)	4101848..4103674	+	1827	WP_217307579.1	acyl-CoA dehydrogenase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-like (18-111)

Antitoxin

• Cro/C1-type helix-turn-helix domain (42-95)

Sequences

Toxin

Protein

• Length: 127 a.a.
• Molecular weight: 14226.94 Da
• Isoelectric Point: 4.9496

>T207305 WP_254407181.1 NZ_CP077658:c4099848-4099468 [Streptomyces sp. GMY02]
VSWEIILCKEVHDWYLDLAEKDPESAHLVEQAIDLLAESGPTLGRPMVDRVGRSRHHNMKELRPGSVGSSEIRMLFAFDP
KRQALIMVAGDKNGTWNGWYDRNIPIADERFDQHLDDLNNTGGSGT

Nucleotide

• Length: 381 bp

>T207305 NZ_CP102956:c1883088-1882936 [Staphylococcus aureus]
ATGTCTAAAGACAAAGATCCAAAATTAAATTATCATGAAGAAGAAAACAGTATTGTAACGGATTTTGAAGATTTAAAAGA
ATTAGGTAAAGAAATGGAACAAATCTCTGATCAAAATGATCAAGAAAAGAATTCTGAAGAAGACAGTCAGTAA

Antitoxin

Protein

• Length: 110 a.a.
• Molecular weight: 12063.49 Da
• Isoelectric Point: 6.4795

>AT207305 WP_217307576.1 NZ_CP077658:c4099411-4099082 [Streptomyces sp. GMY02]
MHNWKDTKAEAAAIHETNGTQISDERKAAIREGMESRIRAYRLAEIREEQALTQTDVAKAMGTTQSNVSRFERGELGRSE
LATIAAYVEALGGTLRLVADFGDRQLRVG

Nucleotide

• Length: 330 bp

>AT207305 NZ_CP102956:c1883712-1883113 [Staphylococcus aureus]
ATGGCAATGAACTTTAAAGTCTTTGACAATAGTCAACTTGTAGCAGAATATGCTGCTGATATTATTAGAAAGCAATTTAA
CAATAATCCTACTACAATTGCAGGTTTTCATTTAGATACAGATCAAGCGCCAGTTCTAGATGAATTAAAGAAAAATGTTG
AAAAACATGCTGTTGATTTTAGCCAAATAAATATTTTAGATTATGACGATAAAAAATCATATTTCGAAGCGTTAGGTGTA
CCAGCAGGTCAAGTTTATCCAATTGCTTATGAAAAAGATGCAATCGAATTAATCGCTGATAAGATTAAAACTAAAGAAAA
TAAAGGGAAATTAACATTACAAGTTGTTTCTATCGATGAGCAAGGTAAGTTAAATGTTAGTATTCGTCAAGGACTAATGG
AAGCAAGAGAAATTTTCTTAGTAGTGACAGGTGCTAATAAACGAGATGTAGTTGAAAAATTATATCAAGAAAATGGTAAA
ACAAGCTTCGAACCAGCCGATTTAAAAGCACATAGAATGGTAAATGTTATTCTTGATAAAGAAGCGGCTGCAGGTTTACC
TGAAGATGTTAAAGCTTACTTTACGTCACGCTTTGCTTAA