Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) prlF-yhaV (relBE)/YhaV-PrlF
Location 3120717..3121516 Replicon chromosome
Accession NZ_CP077646
Organism Escherichia coli strain ST866

Toxin (Protein)


Gene name yhaV Uniprot ID U9XVR9
Locus tag KTN06_RS14940 Protein ID WP_000347267.1
Coordinates 3120717..3121181 (-) Length 155 a.a.

Antitoxin (Protein)


Gene name prlF Uniprot ID S1EB98
Locus tag KTN06_RS14945 Protein ID WP_001307405.1
Coordinates 3121181..3121516 (-) Length 112 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KTN06_RS14910 (3115718) 3115718..3116152 - 435 WP_000948824.1 PTS galactosamine/N-acetylgalactosamine transporter subunit IIA -
KTN06_RS14915 (3116170) 3116170..3117048 - 879 WP_001298758.1 PTS N-acetylgalactosamine transporter subunit IID -
KTN06_RS14920 (3117038) 3117038..3117817 - 780 WP_157702017.1 PTS N-acetylgalactosamine transporter subunit IIC -
KTN06_RS14925 (3117828) 3117828..3118301 - 474 WP_016235805.1 PTS N-acetylgalactosamine transporter subunit IIB -
KTN06_RS14930 (3118324) 3118324..3119604 - 1281 WP_000681920.1 tagatose-bisphosphate aldolase subunit KbaZ -
KTN06_RS14935 (3119853) 3119853..3120662 + 810 WP_000072193.1 aga operon transcriptional regulator AgaR -
KTN06_RS14940 (3120717) 3120717..3121181 - 465 WP_000347267.1 type II toxin-antitoxin system ribonuclease toxin YhaV Toxin
KTN06_RS14945 (3121181) 3121181..3121516 - 336 WP_001307405.1 type II toxin-antitoxin system antitoxin PrlF Antitoxin
KTN06_RS14950 (3121665) 3121665..3123236 - 1572 WP_001273741.1 galactarate dehydratase -
KTN06_RS14955 (3123611) 3123611..3124945 + 1335 WP_000599636.1 galactarate/glucarate/glycerate transporter GarP -
KTN06_RS14960 (3124961) 3124961..3125731 + 771 WP_001058227.1 2-dehydro-3-deoxyglucarate aldolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin endonuclease, YhaV

(12-150)

Antitoxin

PrlF antitoxin

(14-110)


Sequences

Toxin        


Download         Length: 155 a.a.        Molecular weight: 17807.17 Da        Isoelectric Point: 9.4947

>T207259 WP_000347267.1 NZ_CP077646:c3121181-3120717 [Escherichia coli]
MDFPQRVNGWALYAHPCFQETYDALVAEVETLKGKDPENYQRKAATKLLAVVHKVIEEHITVNPSSPAFRHGKSLGSGKN
KDWSRVKFGAGRYRLFFRYSEKEKVIILGWMNDENTLRTYGKKTDAYTVFSKMLKRGHPPADWESLTQETEENH

Download         Length: 465 bp

>T207259 NZ_CP102947:3632109-3632327 [Escherichia coli]
ATGTCCGAAAAACCTTTAACGAAAACCGATTATTTAATGCGTTTACGTCGTTGCCAGACAATTGACACGCTGGAGCGTGT
TATCGAGAAAAATAAATACGAATTATCAGATAATGAACTGGCGGTATTTTACTCAGCCGCAGATCACCGCCTCGCCGAAT
TGACCATGAATAAACTGTACGACAAGATCCCTTCCTCAGTATGGAAATTTATTCGCTAA

Antitoxin


Download         Length: 112 a.a.        Molecular weight: 12358.94 Da        Isoelectric Point: 4.8616

>AT207259 WP_001307405.1 NZ_CP077646:c3121516-3121181 [Escherichia coli]
MPANARSHAVLTTESKVTIRGQTTIPAPVREALKLKPGQDSIHYEILPGGQVFMCRLGDEQEDHTMNAFLRFLDADIQNN
PQKTRPFNIQQGKKLVAGMDVNIDDEIGDDE

Download         Length: 336 bp

>AT207259 NZ_CP102947:3631709-3632083 [Escherichia coli]
ATGGATGAATACTCACCCAAAAGACATGATATCGCACAGCTTAAGTTTCTCTGTGAAACCCTGTATCATGACTGCCTTGC
AAACCTTGAAGAAAGCAATCATGGCTGGGTTAACGACCCAACCTCGGCGATCAACCTCCAGTTGAATGAACTGATTGAGC
ATATTGCGACCTTCGCACTTAATTACAAAATTAAGTATAATGAAGACAATAAGCTCATTGAGCAGATCGACGAATATCTG
GATGACACCTTTATGTTGTTCAGTAGTTATGGTATTAATATGCAGGATCTTCAGAAATGGCGGAAGTCAGGTAATCGACT
ATTCCGTTGTTTTGTCAATGCGACGAAAGAGAATCCTGCGAGTTTATCTTGTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0XTR4

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0XVC7

References