Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HTH(antitoxin)
Location 2326804..2327406 Replicon chromosome
Accession NZ_CP077646
Organism Escherichia coli strain ST866

Toxin (Protein)


Gene name higB Uniprot ID U9XIS6
Locus tag KTN06_RS11090 Protein ID WP_000897305.1
Coordinates 2327095..2327406 (-) Length 104 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag KTN06_RS11085 Protein ID WP_000356397.1
Coordinates 2326804..2327094 (-) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KTN06_RS11060 (2322730) 2322730..2323632 + 903 WP_000331377.1 formate dehydrogenase O subunit beta -
KTN06_RS11065 (2323629) 2323629..2324264 + 636 WP_000829013.1 formate dehydrogenase cytochrome b556 subunit -
KTN06_RS11070 (2324261) 2324261..2325190 + 930 WP_000027708.1 formate dehydrogenase accessory protein FdhE -
KTN06_RS11075 (2325519) 2325519..2325761 - 243 WP_001087409.1 protein YiiF -
KTN06_RS11080 (2325981) 2325981..2326199 - 219 WP_001315930.1 CopG family transcriptional regulator -
KTN06_RS11085 (2326804) 2326804..2327094 - 291 WP_000356397.1 NadS family protein Antitoxin
KTN06_RS11090 (2327095) 2327095..2327406 - 312 WP_000897305.1 hypothetical protein Toxin
KTN06_RS11095 (2327635) 2327635..2328543 + 909 WP_217609456.1 alpha/beta hydrolase -
KTN06_RS11100 (2328607) 2328607..2329548 - 942 WP_001297068.1 fatty acid biosynthesis protein FabY -
KTN06_RS11105 (2329593) 2329593..2330030 - 438 WP_000560983.1 D-aminoacyl-tRNA deacylase -
KTN06_RS11110 (2330027) 2330027..2330899 - 873 WP_000920762.1 virulence factor BrkB family protein -
KTN06_RS11115 (2330893) 2330893..2331492 - 600 WP_001295269.1 glucose-1-phosphatase -
KTN06_RS11120 (2331591) 2331591..2332376 - 786 WP_000059678.1 DeoR/GlpR family DNA-binding transcription regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Cro/C1-type helix-turn-helix domain

(36-85)


Sequences

Toxin        


Download         Length: 104 a.a.        Molecular weight: 12190.19 Da        Isoelectric Point: 9.7791

>T207257 WP_000897305.1 NZ_CP077646:c2327406-2327095 [Escherichia coli]
MLFIETEIFTEDVQKLLTDDEFSRFQFFLALNPDYGEVIPETGGLRKVRWVSGGKGKRAGVRVIYFHQVKHYEIRLLLIY
RKGIKDDLSPQEKAMLRLLNTRW

Download         Length: 312 bp

>T207257 NZ_CP102947:2774973-2775080 [Escherichia coli]
ATGACGCTCGCGCAGTTTGCCATGATTTTCTGGCACAACCTGGCGGCACCGATCCTGGCGGGGATTATTACCGCAGTGAT
TGTCAGCTGGTGGCGTAACCGGAAGTAA

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10846.43 Da        Isoelectric Point: 10.8907

>AT207257 WP_000356397.1 NZ_CP077646:c2327094-2326804 [Escherichia coli]
MDKALFERLTHSMAQMNEIIEGTRQPSRTFEVDAMKIKEIRRASGLSQSKFADLISVSVDTLRNWEQGRRSPTGPAKALL
RAIANDPQHVLQALNR

Download         Length: 291 bp

>AT207257 NZ_CP102947:c2774916-2774861 [Escherichia coli]
CAAGATTAGCCCCCGTTCTGTTGTCAGGTTGTACCTCTCAACGTGCGGGGGTTTTC

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0Y7I7

Antitoxin

Source ID Structure

References