Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 935666..936266 Replicon chromosome
Accession NZ_CP077603
Organism Neisseria meningitidis strain S4

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag KSP27_RS04720 Protein ID WP_002221019.1
Coordinates 935666..935947 (+) Length 94 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag KSP27_RS04725 Protein ID WP_002221020.1
Coordinates 935955..936266 (+) Length 104 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KSP27_RS04685 931111..931782 + 672 WP_002217215.1 CsgG/HfaB family protein -
KSP27_RS04690 931792..932160 + 369 WP_002219297.1 DUF4810 domain-containing protein -
KSP27_RS04695 932157..932804 + 648 WP_002217218.1 DUF799 domain-containing protein -
KSP27_RS04700 933246..934388 + 1143 WP_002221015.1 SbmA/BacA-like family transporter -
KSP27_RS04705 934498..934707 - 210 WP_002221016.1 hypothetical protein -
KSP27_RS04710 934704..935000 - 297 WP_002221017.1 hypothetical protein -
KSP27_RS04715 934979..935584 - 606 WP_002219301.1 hypothetical protein -
KSP27_RS04720 935666..935947 + 282 WP_002221019.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
KSP27_RS04725 935955..936266 + 312 WP_002221020.1 HigA family addiction module antitoxin Antitoxin
KSP27_RS04730 937046..939019 - 1974 WP_002221022.1 pyocin knob domain-containing protein -
KSP27_RS04735 939030..939590 - 561 WP_002213590.1 YmfQ family protein -
KSP27_RS04740 939587..940338 - 752 Protein_924 baseplate J/gp47 family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - - 915672..948260 32588
- flank IS/Tn - - 940427..941392 965


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(5-93)

Antitoxin

Toxin-antitoxin system, antidote protein, HigA

(3-80)


Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 10368.85 Da        Isoelectric Point: 10.0980

>T207243 WP_002221019.1 NZ_CP077603:935666-935947 [Neisseria meningitidis]
MMIVSFKHKGLERFFKTGSLSGIQAGHSVKLNLLLTALNAAQTPSDMAVPSWNLHPLKGSLSGHWAVKVNGNWRLTFRFN
DGNAEVVDYQDYH

Download         Length: 282 bp

>T207243 NZ_CP102946:c5246311-5245901 [Pseudomonas aeruginosa]
ATGCTCAAGTTCATGCTCGACACCAACATCTGCATCTTCACCATCAAAAACCGCCCGCAAGAGGTGCGCGAGGCGTTCCT
GCGCCACCACGATCAGATGTGCATCAGCACCGTGACGCTGATGGAGCTGATCTACGGCGCAGAGAAGTCCTCGAACCCCT
CGCGCAATCTTGCAGACGTGGAAGGCTTCGCTGCTCGTCTGGAGGTGCTCAAGTACGACCAGGAAGCTGCCGCCCACACC
GGCCAGCTCCGCGCTGAACTGGCCCGCCTCGGCAAGCAAATCGGCCCCTATGACCAGATGATTGCCGGGCACGCCCGCTC
TCAGGGCCTGATCGTGGTCACCAATAACCGCCGCGAGTTCGACCGCGTACCCGGCTTGAGAGTTGAGGACTGGGTCGTCC
CAATCGTGTAA

Antitoxin


Download         Length: 104 a.a.        Molecular weight: 11476.32 Da        Isoelectric Point: 10.5523

>AT207243 WP_002221020.1 NZ_CP077603:935955-936266 [Neisseria meningitidis]
MKMHNPAHPGLVLKEYINGASITDIAKRLGVSRVALSRIVNAQSSITPEMAVRLSQLLNTSPDFWLNMQAGYDLWQIRQR
KTFDIAPLFPEPPLSSMQTGARA

Download         Length: 312 bp

>AT207243 NZ_CP102946:c5246541-5246311 [Pseudomonas aeruginosa]
ATGGAACAAGGTTCTGTTTTTCAGAGCAATCGTAGCCAGGCCGTAAGACTGCCCAAGGCAGTCGCGCTTCCCGATGACGT
TAAGCGTGTGGATGTGGTCGTTGTGGGGCGCGCCAGAATCATCACGCCTGCCGGCGAGTCTTGGGATAGCTGGTTCGATG
GCGAGGGCGTTACTGCCGACTTTATGGCAGAGCGTGAACAGCCTGCCGATCAGGAGCGCGAGACTTTCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References