Detailed information of TA system TA207243

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): higBA (relBE)/HigB-HigA
• Location: 935666..936266
• Replicon: chromosome
• Accession: NZ_CP077603
• Organism: Neisseria meningitidis strain S4

Toxin (Protein)

• Gene name: higB
• Uniprot ID: -
• Locus tag: KSP27_RS04720
• Protein ID: WP_002221019.1
• Coordinates: 935666..935947 (+)
• Length: 94 a.a.

Antitoxin (Protein)

• Gene name: higA
• Uniprot ID: -
• Locus tag: KSP27_RS04725
• Protein ID: WP_002221020.1
• Coordinates: 935955..936266 (+)
• Length: 104 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KSP27_RS04685	931111..931782	+	672	WP_002217215.1	CsgG/HfaB family protein	-
KSP27_RS04690	931792..932160	+	369	WP_002219297.1	DUF4810 domain-containing protein	-
KSP27_RS04695	932157..932804	+	648	WP_002217218.1	DUF799 domain-containing protein	-
KSP27_RS04700	933246..934388	+	1143	WP_002221015.1	SbmA/BacA-like family transporter	-
KSP27_RS04705	934498..934707	-	210	WP_002221016.1	hypothetical protein	-
KSP27_RS04710	934704..935000	-	297	WP_002221017.1	hypothetical protein	-
KSP27_RS04715	934979..935584	-	606	WP_002219301.1	hypothetical protein	-
KSP27_RS04720	935666..935947	+	282	WP_002221019.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
KSP27_RS04725	935955..936266	+	312	WP_002221020.1	HigA family addiction module antitoxin	Antitoxin
KSP27_RS04730	937046..939019	-	1974	WP_002221022.1	pyocin knob domain-containing protein	-
KSP27_RS04735	939030..939590	-	561	WP_002213590.1	YmfQ family protein	-
KSP27_RS04740	939587..940338	-	752	Protein_924	baseplate J/gp47 family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Integrative and Conjugative Element	-	-	915672..948260	32588
	-	flank	IS/Tn	-	-	940427..941392	965

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-1 (5-93)

Antitoxin

• Toxin-antitoxin system, antidote protein, HigA (3-80)

Sequences

Toxin

Protein

• Length: 94 a.a.
• Molecular weight: 10368.85 Da
• Isoelectric Point: 10.0980

>T207243 WP_002221019.1 NZ_CP077603:935666-935947 [Neisseria meningitidis]
MMIVSFKHKGLERFFKTGSLSGIQAGHSVKLNLLLTALNAAQTPSDMAVPSWNLHPLKGSLSGHWAVKVNGNWRLTFRFN
DGNAEVVDYQDYH

Nucleotide

• Length: 282 bp

>T207243 NZ_CP102946:c5246311-5245901 [Pseudomonas aeruginosa]
ATGCTCAAGTTCATGCTCGACACCAACATCTGCATCTTCACCATCAAAAACCGCCCGCAAGAGGTGCGCGAGGCGTTCCT
GCGCCACCACGATCAGATGTGCATCAGCACCGTGACGCTGATGGAGCTGATCTACGGCGCAGAGAAGTCCTCGAACCCCT
CGCGCAATCTTGCAGACGTGGAAGGCTTCGCTGCTCGTCTGGAGGTGCTCAAGTACGACCAGGAAGCTGCCGCCCACACC
GGCCAGCTCCGCGCTGAACTGGCCCGCCTCGGCAAGCAAATCGGCCCCTATGACCAGATGATTGCCGGGCACGCCCGCTC
TCAGGGCCTGATCGTGGTCACCAATAACCGCCGCGAGTTCGACCGCGTACCCGGCTTGAGAGTTGAGGACTGGGTCGTCC
CAATCGTGTAA

Antitoxin

Protein

• Length: 104 a.a.
• Molecular weight: 11476.32 Da
• Isoelectric Point: 10.5523

>AT207243 WP_002221020.1 NZ_CP077603:935955-936266 [Neisseria meningitidis]
MKMHNPAHPGLVLKEYINGASITDIAKRLGVSRVALSRIVNAQSSITPEMAVRLSQLLNTSPDFWLNMQAGYDLWQIRQR
KTFDIAPLFPEPPLSSMQTGARA

Nucleotide

• Length: 312 bp

>AT207243 NZ_CP102946:c5246541-5246311 [Pseudomonas aeruginosa]
ATGGAACAAGGTTCTGTTTTTCAGAGCAATCGTAGCCAGGCCGTAAGACTGCCCAAGGCAGTCGCGCTTCCCGATGACGT
TAAGCGTGTGGATGTGGTCGTTGTGGGGCGCGCCAGAATCATCACGCCTGCCGGCGAGTCTTGGGATAGCTGGTTCGATG
GCGAGGGCGTTACTGCCGACTTTATGGCAGAGCGTGAACAGCCTGCCGATCAGGAGCGCGAGACTTTCTGA