Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | higBA (relBE)/HigB-HigA |
| Location | 17939..18554 | Replicon | chromosome |
| Accession | NZ_CP077425 | ||
| Organism | Vibrio mimicus strain Y4 | ||
Toxin (Protein)
| Gene name | higB | Uniprot ID | Q9KMG5 |
| Locus tag | KSS82_RS00155 | Protein ID | WP_001162670.1 |
| Coordinates | 17939..18226 (+) | Length | 96 a.a. |
Antitoxin (Protein)
| Gene name | higA | Uniprot ID | - |
| Locus tag | KSS82_RS00160 | Protein ID | WP_001232701.1 |
| Coordinates | 18237..18554 (+) | Length | 106 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| KSS82_RS20435 | 13665..13727 | + | 63 | Protein_27 | acetyltransferase | - |
| KSS82_RS00120 (KSS82_00120) | 13767..14684 | + | 918 | WP_217009283.1 | ATP-binding protein | - |
| KSS82_RS00125 (KSS82_00125) | 14729..15918 | + | 1190 | WP_088124793.1 | IS3 family transposase | - |
| KSS82_RS00130 (KSS82_00130) | 16044..16346 | + | 303 | WP_217009284.1 | hypothetical protein | - |
| KSS82_RS00135 (KSS82_00135) | 16549..16806 | + | 258 | WP_000861987.1 | type II toxin-antitoxin system Phd/YefM family antitoxin | - |
| KSS82_RS00140 (KSS82_00140) | 16794..17096 | + | 303 | WP_000807826.1 | type II toxin-antitoxin system RelE/ParE family toxin | - |
| KSS82_RS00145 (KSS82_00145) | 17256..17714 | + | 459 | WP_041051874.1 | hypothetical protein | - |
| KSS82_RS00150 (KSS82_00150) | 17776..17898 | + | 123 | WP_217009285.1 | acetyltransferase | - |
| KSS82_RS00155 (KSS82_00155) | 17939..18226 | + | 288 | WP_001162670.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
| KSS82_RS00160 (KSS82_00160) | 18237..18554 | + | 318 | WP_001232701.1 | HigA family addiction module antitoxin | Antitoxin |
| KSS82_RS00165 (KSS82_00165) | 18644..19006 | + | 363 | WP_170831679.1 | DUF4144 domain-containing protein | - |
| KSS82_RS00170 (KSS82_00170) | 19039..19830 | + | 792 | WP_000417875.1 | PhzF family phenazine biosynthesis protein | - |
| KSS82_RS00175 (KSS82_00175) | 20156..20359 | + | 204 | WP_142610251.1 | hypothetical protein | - |
| KSS82_RS00180 (KSS82_00180) | 20585..21316 | + | 732 | WP_217009286.1 | DUF2971 domain-containing protein | - |
| KSS82_RS00185 (KSS82_00185) | 21520..21909 | + | 390 | WP_000491261.1 | VOC family protein | - |
| KSS82_RS00190 (KSS82_00190) | 22466..23071 | + | 606 | WP_217009287.1 | DUF922 domain-containing protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Integron | - | cqsA / hlyA / vgrG-3 / vasL / icmF/vasK / vasJ / vasI / vasH / clpB/vasG / vasF / vasE / vasD / vasC / vasB / vasA / VCA0109 / vipB/mglB / vipA/mglA / vgrG-2 / hcp-2 / hlyA | 1..1082609 | 1082608 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 96 a.a. Molecular weight: 11349.95 Da Isoelectric Point: 6.7187
>T207220 WP_001162670.1 NZ_CP077425:17939-18226 [Vibrio mimicus]
MALEFKDKWLEQFYEDDKRHRLIPSSIENALFRKLEILDAAQAESDLRIPPGNRFEHLEGNLKGWCSIRVNKQYRLIFQW
VDGVALNTYLDPHKY
MALEFKDKWLEQFYEDDKRHRLIPSSIENALFRKLEILDAAQAESDLRIPPGNRFEHLEGNLKGWCSIRVNKQYRLIFQW
VDGVALNTYLDPHKY
Download Length: 288 bp
>T207220 NZ_CP102944:168810-169103 [Pseudomonas aeruginosa]
ATGCCACAAGTGATCCTCTCTCCGGCTGCTCTGCGTGACCTTAAACGGCTGCGCGAGTTCTTGCACAGTAAGAGCCCAGT
TGTTGCACAGCGAGCAGCCCAAACCATCCGTTCGGCGCTGGCCCAGCTCGGGCAACAACCCGCGATGGGGCGTCCTATTG
AAGGGCTCCCGGAGGTGTTCCGCGAGTGGGTCATCCCCTTTGGGGACAGTGGTTATCTGGCGCGTTACCGCCTAGAGGGC
GAAACCGTAGTGATCTTGGCTCTGCGTCACCAGCGCGAAGCCGGGTTTATTTAG
ATGCCACAAGTGATCCTCTCTCCGGCTGCTCTGCGTGACCTTAAACGGCTGCGCGAGTTCTTGCACAGTAAGAGCCCAGT
TGTTGCACAGCGAGCAGCCCAAACCATCCGTTCGGCGCTGGCCCAGCTCGGGCAACAACCCGCGATGGGGCGTCCTATTG
AAGGGCTCCCGGAGGTGTTCCGCGAGTGGGTCATCCCCTTTGGGGACAGTGGTTATCTGGCGCGTTACCGCCTAGAGGGC
GAAACCGTAGTGATCTTGGCTCTGCGTCACCAGCGCGAAGCCGGGTTTATTTAG
Antitoxin
Download Length: 106 a.a. Molecular weight: 11705.63 Da Isoelectric Point: 10.4711
>AT207220 WP_001232701.1 NZ_CP077425:18237-18554 [Vibrio mimicus]
MRKTKRRPVSVGEMLKVEFLEPMGITSKALAEAMGVHRNTVSNLINGGVLTAPVAIKLAAALGNTPEFWLNIQHAVDLWD
TRNRYQEEAKFVKPLFVSLEQSART
MRKTKRRPVSVGEMLKVEFLEPMGITSKALAEAMGVHRNTVSNLINGGVLTAPVAIKLAAALGNTPEFWLNIQHAVDLWD
TRNRYQEEAKFVKPLFVSLEQSART
Download Length: 318 bp
>AT207220 NZ_CP102944:168535-168822 [Pseudomonas aeruginosa]
ATGTCCGCAGCTACCAAACCCATGTCTATCAAACTTGATAGCGATACCCAAAGCCGGATCAAGCAGCTAGCTGCTGCCCG
CGACCGTTCAGCGCACTGGATGATGCGCGAAGCTATCACCCAGTATGTTGAGCGCGAAGAGCGCAAGGAGGCGTTCCGCC
GCGATACCCTCGATGCTTGGCAGGAGTTTCAGGAGACTGGTTTGCATGTCTCTCTTGAGGAGACCGATCAGTGGTTGGCT
GGTTGGGGCACCGAGATTGAAGGTGGTGCACCTGCATGCCACAAGTGA
ATGTCCGCAGCTACCAAACCCATGTCTATCAAACTTGATAGCGATACCCAAAGCCGGATCAAGCAGCTAGCTGCTGCCCG
CGACCGTTCAGCGCACTGGATGATGCGCGAAGCTATCACCCAGTATGTTGAGCGCGAAGAGCGCAAGGAGGCGTTCCGCC
GCGATACCCTCGATGCTTGGCAGGAGTTTCAGGAGACTGGTTTGCATGTCTCTCTTGAGGAGACCGATCAGTGGTTGGCT
GGTTGGGGCACCGAGATTGAAGGTGGTGCACCTGCATGCCACAAGTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|