Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HTH(antitoxin)
Location 3963587..3964189 Replicon chromosome
Accession NZ_CP077411
Organism Enterobacter asburiae strain FDAARGOS 1432

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag I6L62_RS18920 Protein ID WP_217071955.1
Coordinates 3963878..3964189 (-) Length 104 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag I6L62_RS18915 Protein ID WP_048975654.1
Coordinates 3963587..3963877 (-) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
I6L62_RS18900 (I6L62_18900) 3961086..3961988 + 903 WP_010436855.1 formate dehydrogenase subunit beta -
I6L62_RS18905 (I6L62_18905) 3961985..3962620 + 636 WP_010436852.1 formate dehydrogenase cytochrome b556 subunit -
I6L62_RS18910 (I6L62_18910) 3962617..3963546 + 930 WP_023309751.1 formate dehydrogenase accessory protein FdhE -
I6L62_RS18915 (I6L62_18915) 3963587..3963877 - 291 WP_048975654.1 NadS family protein Antitoxin
I6L62_RS18920 (I6L62_18920) 3963878..3964189 - 312 WP_217071955.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
I6L62_RS18925 (I6L62_18925) 3964338..3965279 - 942 WP_039264191.1 fatty acid biosynthesis protein FabY -
I6L62_RS18930 (I6L62_18930) 3965324..3965761 - 438 WP_033146964.1 D-aminoacyl-tRNA deacylase -
I6L62_RS18935 (I6L62_18935) 3965758..3966639 - 882 WP_033146965.1 virulence factor BrkB family protein -
I6L62_RS18940 (I6L62_18940) 3966633..3967232 - 600 WP_033146966.1 glucose-1-phosphatase -
I6L62_RS18945 (I6L62_18945) 3967639..3968415 + 777 WP_217071956.1 hypothetical protein -
I6L62_RS18950 (I6L62_18950) 3968418..3968702 + 285 WP_217071957.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Cro/C1-type helix-turn-helix domain

(36-85)


Sequences

Toxin        


Download         Length: 104 a.a.        Molecular weight: 12188.18 Da        Isoelectric Point: 9.7548

>T207178 WP_217071955.1 NZ_CP077411:c3964189-3963878 [Enterobacter asburiae]
MLFIETDIFTEDVKTLLDDDEYHRFQVFLAPQPEFGDLIQNTGGLRKIRWLAGGKGKRGGVRVIYFHRTREYEIRLLLIY
RKGIKDDLSASEKAILKKMIERW

Download         Length: 312 bp

>T207178 NZ_CP102928:804835-805122 [Vibrio cholerae]
ATGACCTATAAGTTAAAGTTTCTGCCGGCTGCGCAAAAGGAATGGAGTAAGTTAGCTCCGACAATTCAGAGTCAGTTCAA
GAAGAAGTTAAAGGAACGATTAGAAAATCCGCACGTCCCTTCGGCTAAGCTTCGAGGATACGACGCTGTTTACAAGATTA
AACTTCGTACGGCGGGTTATCGTTTAGCTTATGAGGTTATTGACGATGAGATAGTTGTCTATGTCCTTGCTGTCGGTAAA
CGTGACAAAGATGCTGTCTATAAAAAACTGGCTTCACGCTTCGGTTAG

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10703.30 Da        Isoelectric Point: 10.8780

>AT207178 WP_048975654.1 NZ_CP077411:c3963877-3963587 [Enterobacter asburiae]
MDKALFERLTKSMAQMNEIAEGKREPSRTFQIDAIKIKEIRQASGLSQSKFANLISVSVDTLRNWEQGRRSPTGPAKALL
RAIANDPQHVIPALSQ

Download         Length: 291 bp

>AT207178 NZ_CP102928:804594-804845 [Vibrio cholerae]
ATGAGACAAGTTTTAGCGAATTGCTCTGCAAGTATTTCAGAGTTAAAGAAGAACCCAACAGCTTTGTTGAATGAGGCTGA
TGGGTCTGCAATTGCAATTTTAAACCACAACAAGCCAGCGGCTTACCTTGTGCCAGCGGAAACGTATGAGTATCTCATCG
ATATGCTCGATGATTATGAGCTTTCCCAAATTGTCGATAGTCGCCGAGCTGACTTAGCACAAGCTGTGGAAGTAAATATT
GATGACCTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References