Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 2987251..2987908 Replicon chromosome
Accession NZ_CP077411
Organism Enterobacter asburiae strain FDAARGOS 1432

Toxin (Protein)


Gene name higB Uniprot ID A0A808IF03
Locus tag I6L62_RS14210 Protein ID WP_033146338.1
Coordinates 2987251..2987550 (+) Length 100 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID A0A808ICP3
Locus tag I6L62_RS14215 Protein ID WP_033146339.1
Coordinates 2987561..2987908 (+) Length 116 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
I6L62_RS14200 (I6L62_14200) 2983620..2985818 + 2199 WP_217071732.1 type I secretion system permease/ATPase -
I6L62_RS14205 (I6L62_14205) 2985829..2986998 + 1170 WP_086374946.1 HlyD family efflux transporter periplasmic adaptor subunit -
I6L62_RS14210 (I6L62_14210) 2987251..2987550 + 300 WP_033146338.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
I6L62_RS14215 (I6L62_14215) 2987561..2987908 + 348 WP_033146339.1 HigA family addiction module antitoxin Antitoxin
I6L62_RS14220 (I6L62_14220) 2987953..2988378 + 426 WP_217071733.1 nucleoside triphosphatase NudI -
I6L62_RS14225 (I6L62_14225) 2988350..2989081 - 732 WP_211438841.1 helix-turn-helix transcriptional regulator -
I6L62_RS14230 (I6L62_14230) 2989179..2989646 + 468 WP_217071734.1 nuclear transport factor 2 family protein -
I6L62_RS14235 (I6L62_14235) 2989601..2990119 - 519 WP_217071735.1 hypothetical protein -
I6L62_RS14240 (I6L62_14240) 2990205..2991386 - 1182 WP_217071736.1 PLP-dependent aminotransferase family protein -
I6L62_RS14245 (I6L62_14245) 2991536..2991892 + 357 WP_032647964.1 hypothetical protein -
I6L62_RS14250 (I6L62_14250) 2991885..2992778 - 894 WP_217071737.1 LysR family transcriptional regulator -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(1-95)

Antitoxin

(8-86)


Sequences


Toxin        


Download         Length: 100 a.a.        Molecular weight: 11691.32 Da        Isoelectric Point: 10.0346

>T207176 WP_033146338.1 NZ_CP077411:2987251-2987550 [Enterobacter asburiae]
MISYFRDQWLEDFFLYGRSSNVIPANLETALARKLDIIRAATSHRDLRSPPGNMYEALNPPLKGYSSIRVNRQYRLVFRW
TEGKAEDLYLSPHKYTQHK

Download         Length: 300 bp

>T207176 NZ_CP102928:799543-799875 [Vibrio cholerae]
ATGAAAAGTGTATTTGTCGAATCAACAATTTTTGAAAAGTACCGAGATGAATATCTCAGTGATGAGGAGTATAGGCTCTT
TCAAGCAGAGCTAATGCTAAACCCCAAGCTGGGTGATGTGATTCAAGGTACTGGCGGTTTGCGAAAAATTCGAGTTGCGA
GTAAAGGCAAGGGAAAGCGTGGTGGTTCACGGATTATCTATTACTTTCTCGATGAAAAGAGGCGTTTCTATTTGCTAACC
ATTTACGGCAAAAATGAAATGTCTGACTTGAATGCAAATCAAAGGAAACAACTAATGGCTTTTATGGAGGCGTGGCGCAA
TGAGCAATCGTGA

Antitoxin


Download         Length: 116 a.a.        Molecular weight: 13066.02 Da        Isoelectric Point: 7.0134

>AT207176 WP_033146339.1 NZ_CP077411:2987561-2987908 [Enterobacter asburiae]
MTLQQALRKPTTPGDVLQYEYLEPLNLKISDLAEMLNVHRNTISALVNNNRKLTADMAIKLAKAFDTTIEFWLNLQLNVD
IWEAQSNPRTQEELSRIKTVADVMAKRKSGQPDVA

Download         Length: 348 bp

>AT207176 NZ_CP102928:799862-800176 [Vibrio cholerae]
ATGAGCAATCGTGATTTATTTGCAGAGTTAAGCTCAGCTCTTGTTGAGGCTAAGCAGCATTCAGAAGGTAAGCTTACTCT
GAAAACACATCATGTGAATGATGTGGGTGAGTTGAACATCTCACCGGATGAAATCGTGAGTATTCGCGAGCAGTTCAATA
TGTCCCGCGGAGTCTTCGCGCGGTTACTTCATACGTCTTCGCGCACATTAGAAAACTGGGAACAAGGTCGTAGTGTGCCA
AATGGTCAAGCGGTCACTCTTTTAAAGTTAGTACAGCGTCATCCAGAAACGTTGTCACACATAGCCGAGCTATAA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
AlphaFold DB A0A808IF03


Antitoxin

Source ID Structure
AlphaFold DB A0A808ICP3

References