Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | higBA (relBE)/HigB-HigA |
Location | 2987251..2987908 | Replicon | chromosome |
Accession | NZ_CP077411 | ||
Organism | Enterobacter asburiae strain FDAARGOS 1432 |
Toxin (Protein)
Gene name | higB | Uniprot ID | A0A808IF03 |
Locus tag | I6L62_RS14210 | Protein ID | WP_033146338.1 |
Coordinates | 2987251..2987550 (+) | Length | 100 a.a. |
Antitoxin (Protein)
Gene name | higA | Uniprot ID | A0A808ICP3 |
Locus tag | I6L62_RS14215 | Protein ID | WP_033146339.1 |
Coordinates | 2987561..2987908 (+) | Length | 116 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
I6L62_RS14200 (I6L62_14200) | 2983620..2985818 | + | 2199 | WP_217071732.1 | type I secretion system permease/ATPase | - |
I6L62_RS14205 (I6L62_14205) | 2985829..2986998 | + | 1170 | WP_086374946.1 | HlyD family efflux transporter periplasmic adaptor subunit | - |
I6L62_RS14210 (I6L62_14210) | 2987251..2987550 | + | 300 | WP_033146338.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
I6L62_RS14215 (I6L62_14215) | 2987561..2987908 | + | 348 | WP_033146339.1 | HigA family addiction module antitoxin | Antitoxin |
I6L62_RS14220 (I6L62_14220) | 2987953..2988378 | + | 426 | WP_217071733.1 | nucleoside triphosphatase NudI | - |
I6L62_RS14225 (I6L62_14225) | 2988350..2989081 | - | 732 | WP_211438841.1 | helix-turn-helix transcriptional regulator | - |
I6L62_RS14230 (I6L62_14230) | 2989179..2989646 | + | 468 | WP_217071734.1 | nuclear transport factor 2 family protein | - |
I6L62_RS14235 (I6L62_14235) | 2989601..2990119 | - | 519 | WP_217071735.1 | hypothetical protein | - |
I6L62_RS14240 (I6L62_14240) | 2990205..2991386 | - | 1182 | WP_217071736.1 | PLP-dependent aminotransferase family protein | - |
I6L62_RS14245 (I6L62_14245) | 2991536..2991892 | + | 357 | WP_032647964.1 | hypothetical protein | - |
I6L62_RS14250 (I6L62_14250) | 2991885..2992778 | - | 894 | WP_217071737.1 | LysR family transcriptional regulator | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 100 a.a. Molecular weight: 11691.32 Da Isoelectric Point: 10.0346
>T207176 WP_033146338.1 NZ_CP077411:2987251-2987550 [Enterobacter asburiae]
MISYFRDQWLEDFFLYGRSSNVIPANLETALARKLDIIRAATSHRDLRSPPGNMYEALNPPLKGYSSIRVNRQYRLVFRW
TEGKAEDLYLSPHKYTQHK
MISYFRDQWLEDFFLYGRSSNVIPANLETALARKLDIIRAATSHRDLRSPPGNMYEALNPPLKGYSSIRVNRQYRLVFRW
TEGKAEDLYLSPHKYTQHK
Download Length: 300 bp
>T207176 NZ_CP102928:799543-799875 [Vibrio cholerae]
ATGAAAAGTGTATTTGTCGAATCAACAATTTTTGAAAAGTACCGAGATGAATATCTCAGTGATGAGGAGTATAGGCTCTT
TCAAGCAGAGCTAATGCTAAACCCCAAGCTGGGTGATGTGATTCAAGGTACTGGCGGTTTGCGAAAAATTCGAGTTGCGA
GTAAAGGCAAGGGAAAGCGTGGTGGTTCACGGATTATCTATTACTTTCTCGATGAAAAGAGGCGTTTCTATTTGCTAACC
ATTTACGGCAAAAATGAAATGTCTGACTTGAATGCAAATCAAAGGAAACAACTAATGGCTTTTATGGAGGCGTGGCGCAA
TGAGCAATCGTGA
ATGAAAAGTGTATTTGTCGAATCAACAATTTTTGAAAAGTACCGAGATGAATATCTCAGTGATGAGGAGTATAGGCTCTT
TCAAGCAGAGCTAATGCTAAACCCCAAGCTGGGTGATGTGATTCAAGGTACTGGCGGTTTGCGAAAAATTCGAGTTGCGA
GTAAAGGCAAGGGAAAGCGTGGTGGTTCACGGATTATCTATTACTTTCTCGATGAAAAGAGGCGTTTCTATTTGCTAACC
ATTTACGGCAAAAATGAAATGTCTGACTTGAATGCAAATCAAAGGAAACAACTAATGGCTTTTATGGAGGCGTGGCGCAA
TGAGCAATCGTGA
Antitoxin
Download Length: 116 a.a. Molecular weight: 13066.02 Da Isoelectric Point: 7.0134
>AT207176 WP_033146339.1 NZ_CP077411:2987561-2987908 [Enterobacter asburiae]
MTLQQALRKPTTPGDVLQYEYLEPLNLKISDLAEMLNVHRNTISALVNNNRKLTADMAIKLAKAFDTTIEFWLNLQLNVD
IWEAQSNPRTQEELSRIKTVADVMAKRKSGQPDVA
MTLQQALRKPTTPGDVLQYEYLEPLNLKISDLAEMLNVHRNTISALVNNNRKLTADMAIKLAKAFDTTIEFWLNLQLNVD
IWEAQSNPRTQEELSRIKTVADVMAKRKSGQPDVA
Download Length: 348 bp
>AT207176 NZ_CP102928:799862-800176 [Vibrio cholerae]
ATGAGCAATCGTGATTTATTTGCAGAGTTAAGCTCAGCTCTTGTTGAGGCTAAGCAGCATTCAGAAGGTAAGCTTACTCT
GAAAACACATCATGTGAATGATGTGGGTGAGTTGAACATCTCACCGGATGAAATCGTGAGTATTCGCGAGCAGTTCAATA
TGTCCCGCGGAGTCTTCGCGCGGTTACTTCATACGTCTTCGCGCACATTAGAAAACTGGGAACAAGGTCGTAGTGTGCCA
AATGGTCAAGCGGTCACTCTTTTAAAGTTAGTACAGCGTCATCCAGAAACGTTGTCACACATAGCCGAGCTATAA
ATGAGCAATCGTGATTTATTTGCAGAGTTAAGCTCAGCTCTTGTTGAGGCTAAGCAGCATTCAGAAGGTAAGCTTACTCT
GAAAACACATCATGTGAATGATGTGGGTGAGTTGAACATCTCACCGGATGAAATCGTGAGTATTCGCGAGCAGTTCAATA
TGTCCCGCGGAGTCTTCGCGCGGTTACTTCATACGTCTTCGCGCACATTAGAAAACTGGGAACAAGGTCGTAGTGTGCCA
AATGGTCAAGCGGTCACTCTTTTAAAGTTAGTACAGCGTCATCCAGAAACGTTGTCACACATAGCCGAGCTATAA
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Structures
Toxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A808IF03 |
Antitoxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A808ICP3 |