Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-RelB
Location 1974113..1974626 Replicon chromosome
Accession NZ_CP077404
Organism Streptococcus mutans strain FDAARGOS 1458

Toxin (Protein)


Gene name yoeB Uniprot ID -
Locus tag I6L88_RS09745 Protein ID WP_002270995.1
Coordinates 1974113..1974367 (-) Length 85 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID -
Locus tag I6L88_RS09750 Protein ID WP_002270994.1
Coordinates 1974360..1974626 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
I6L88_RS09710 (I6L88_09710) 1969989..1970405 - 417 WP_002271002.1 conjugal transfer protein -
I6L88_RS09715 (I6L88_09715) 1970407..1970634 - 228 WP_002280083.1 hypothetical protein -
I6L88_RS09720 (I6L88_09720) 1970651..1971643 - 993 WP_002280082.1 conjugal transfer protein -
I6L88_RS09725 (I6L88_09725) 1971653..1972207 - 555 WP_002280081.1 hypothetical protein -
I6L88_RS09730 (I6L88_09730) 1972204..1972440 - 237 WP_002280080.1 hypothetical protein -
I6L88_RS09735 (I6L88_09735) 1972460..1972846 - 387 WP_002280079.1 hypothetical protein -
I6L88_RS09740 (I6L88_09740) 1972824..1974056 - 1233 WP_002280078.1 replication initiation factor domain-containing protein -
I6L88_RS09745 (I6L88_09745) 1974113..1974367 - 255 WP_002270995.1 Txe/YoeB family addiction module toxin Toxin
I6L88_RS09750 (I6L88_09750) 1974360..1974626 - 267 WP_002270994.1 type II toxin-antitoxin system prevent-host-death family antitoxin Antitoxin
I6L88_RS09755 (I6L88_09755) 1974890..1976548 - 1659 WP_002280077.1 FtsK/SpoIIIE domain-containing protein -
I6L88_RS09760 (I6L88_09760) 1976555..1976965 - 411 WP_002280076.1 DUF961 family protein -
I6L88_RS09765 (I6L88_09765) 1976988..1977302 - 315 WP_000406626.1 hypothetical protein -
I6L88_RS09770 (I6L88_09770) 1977641..1977937 - 297 WP_231872042.1 hypothetical protein -
I6L88_RS09775 (I6L88_09775) 1978006..1978284 - 279 WP_002280073.1 type II toxin-antitoxin system YafQ family toxin -
I6L88_RS09780 (I6L88_09780) 1978285..1978557 - 273 WP_002280072.1 type II toxin-antitoxin system RelB/DinJ family antitoxin -
I6L88_RS09785 (I6L88_09785) 1978709..1979422 + 714 WP_002280071.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(2-83)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-74)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 10474.89 Da        Isoelectric Point: 8.3800

>T207128 WP_002270995.1 NZ_CP077404:c1974367-1974113 [Streptococcus mutans]
MFNFTEQAWKDYVSWQQEDKKILKRINRLIEDIKRNPFEGIGKPEPLKYRYSGAWSRRITDEHRLVYLVEEDEIYFLSFR
DHYK

Download         Length: 255 bp

>T207128 NZ_CP102891:c4617730-4617197 [Klebsiella pneumoniae]
ATGGAGCAGCAACTGACGATTGAGATGATTGCCGATGCGTTCAGCTACGATATCACTGGATTTGATTGCGGCGAGGAAGC
GCTGAATACGTTTTTAAAAGAGCACCTCAAGCGGCAGCACGATGGACAAATCTTAAGGGGTTATGCGCTGGTCTCCGGGG
ATACCGTTCCCAGGTTGCTGGGTTATTACACCTTATCGGGGAGTTGTTTCGAGCGAGGCATGTTGCCGTCTAAAACTCAG
CAAAAGAAAATCCCGTATCAAAATGCGCCAAGCGTAACCCTCGGGCGGCTGGCCATTGATAAATCTGTTCAGGGGCAGGG
CTGGGGAGAGATGTTGGTTGCCCATGCGATGCGAGTGGTGTGGGGAGCGTCTAAAGCCGTTGGTATCTACGGATTGTTTG
TTGAAGCCCTTAATGAGAAGGCTAAAGCATTCTATCTTCGTCTGGGGTTTATACAGCTCGTGGATGAAAATAGTAACTTA
CTGTTTTATCCGACCAAATCGATTGAACAGCTCTTTACTGACGATGAGTCATAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10422.91 Da        Isoelectric Point: 4.6437

>AT207128 WP_002270994.1 NZ_CP077404:c1974626-1974360 [Streptococcus mutans]
MEAVVYSNFRNNLKNYMKKVNDEYEPLMVVNKNPDENIVVLSKENWDSIQETIRLMNNDYLSDKVLSGMEQVKQKKVVQR
QLLEVEDV

Download         Length: 267 bp

>AT207128 NZ_CP102891:c4618007-4617741 [Klebsiella pneumoniae]
ATGCCCGCACTTAAAAAGCAGCGTATAGATTTGAGATTAACCGATGATGATAAGAGCATCATCGAGGAAGCTGCGGCAAT
TTCGAATCAGACGATTACCCAGTTTGTGGTTGCCAGTGCCTCAGAACGTGCTGCGGAAGTGATTGAGCAGCACCGCAGAA
TGGTCCTCAATGAGCAATCATGGAGCCTGGTGATGGAGGCGATTACCCAACCGCCAGCCCCGAATGATCGACTGAAACGT
GCAGCGAAGCGTCTACAAACCAGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References