Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | higBA (relBE)/HigB-VapI |
| Location | 1739355..1739925 | Replicon | chromosome |
| Accession | NZ_CP077403 | ||
| Organism | Jonesia denitrificans strain FDAARGOS 1440 | ||
Toxin (Protein)
| Gene name | graT | Uniprot ID | C7R1W2 |
| Locus tag | I6L70_RS08190 | Protein ID | WP_015771058.1 |
| Coordinates | 1739644..1739925 (-) | Length | 94 a.a. |
Antitoxin (Protein)
| Gene name | higA | Uniprot ID | - |
| Locus tag | I6L70_RS08185 | Protein ID | WP_015771059.1 |
| Coordinates | 1739355..1739657 (-) | Length | 101 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| I6L70_RS08150 (I6L70_08150) | 1735273..1735944 | - | 672 | WP_226926660.1 | hypothetical protein | - |
| I6L70_RS13045 | 1736070..1736204 | + | 135 | WP_264284697.1 | hypothetical protein | - |
| I6L70_RS08155 (I6L70_08155) | 1736584..1737237 | - | 654 | WP_015771065.1 | hypothetical protein | - |
| I6L70_RS08160 (I6L70_08160) | 1737359..1737652 | - | 294 | WP_233459007.1 | type II toxin-antitoxin system RelE/ParE family toxin | - |
| I6L70_RS08165 (I6L70_08165) | 1737720..1738040 | + | 321 | WP_143713239.1 | hypothetical protein | - |
| I6L70_RS08170 (I6L70_08170) | 1738042..1738329 | + | 288 | WP_015771062.1 | transcriptional regulator | - |
| I6L70_RS08175 (I6L70_08175) | 1738367..1738753 | + | 387 | WP_015771061.1 | hypothetical protein | - |
| I6L70_RS08180 (I6L70_08180) | 1738843..1739358 | - | 516 | WP_015771060.1 | GNAT family N-acetyltransferase | - |
| I6L70_RS08185 (I6L70_08185) | 1739355..1739657 | - | 303 | WP_015771059.1 | HigA family addiction module antitoxin | Antitoxin |
| I6L70_RS08190 (I6L70_08190) | 1739644..1739925 | - | 282 | WP_015771058.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
| I6L70_RS08195 (I6L70_08195) | 1740125..1740370 | + | 246 | WP_015771057.1 | hypothetical protein | - |
| I6L70_RS08200 (I6L70_08200) | 1740367..1741356 | + | 990 | WP_015771056.1 | Clp protease N-terminal domain-containing protein | - |
| I6L70_RS08205 (I6L70_08205) | 1741461..1741796 | + | 336 | WP_015771055.1 | hypothetical protein | - |
| I6L70_RS08210 (I6L70_08210) | 1741887..1742114 | + | 228 | WP_015771054.1 | hypothetical protein | - |
| I6L70_RS08215 (I6L70_08215) | 1742150..1742512 | + | 363 | WP_015771053.1 | hypothetical protein | - |
| I6L70_RS08220 (I6L70_08220) | 1742653..1743105 | + | 453 | WP_015771052.1 | type II toxin-antitoxin system prevent-host-death family antitoxin | - |
| I6L70_RS08225 (I6L70_08225) | 1743533..1743730 | + | 198 | WP_015771050.1 | hypothetical protein | - |
| I6L70_RS08230 (I6L70_08230) | 1743723..1744067 | + | 345 | WP_015771049.1 | hypothetical protein | - |
| I6L70_RS08235 (I6L70_08235) | 1744113..1744517 | + | 405 | WP_041288145.1 | hypothetical protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Genomic island | - | - | 1731852..1750558 | 18706 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 94 a.a. Molecular weight: 10927.43 Da Isoelectric Point: 10.9360
>T207125 WP_015771058.1 NZ_CP077403:c1739925-1739644 [Jonesia denitrificans]
VIRSFGDKETERLWRRERVRSIDPRIHRVALRKLRQVGSAESIEDLRVPPGNRLEALKGNRSGQHSIRINDQWRICFVWT
AAGPEEVQIVDYH
VIRSFGDKETERLWRRERVRSIDPRIHRVALRKLRQVGSAESIEDLRVPPGNRLEALKGNRSGQHSIRINDQWRICFVWT
AAGPEEVQIVDYH
Download Length: 282 bp
>T207125 NZ_CP102891:1907438-1907540 [Klebsiella pneumoniae]
GCAAGGCGACTTAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATACA
GGAATCGTATTCGGTCTCTTTTT
GCAAGGCGACTTAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATACA
GGAATCGTATTCGGTCTCTTTTT
Antitoxin
Download Length: 101 a.a. Molecular weight: 11063.60 Da Isoelectric Point: 4.8129
>AT207125 WP_015771059.1 NZ_CP077403:c1739657-1739355 [Jonesia denitrificans]
MTTTDKIEPIHPGEVLMEDFIEGFGITQNKLAVSIGVPPRRINEIVHGKRGITADTALRLAKYFGTSAEFWINLQSHYEL
DRAEDLAGEQIASITPLQVA
MTTTDKIEPIHPGEVLMEDFIEGFGITQNKLAVSIGVPPRRINEIVHGKRGITADTALRLAKYFGTSAEFWINLQSHYEL
DRAEDLAGEQIASITPLQVA
Download Length: 303 bp
>AT207125 NZ_CP102891:c1907547-1907402 [Klebsiella pneumoniae]
TAAAGATAAAAAGAGACCGAATACGATTCCTGTATTCGGTCCAGGGAAATGGCTCTTGGGAGAGAGCCGTGCGCTAAAAG
TTGGCATTAATGCAGGCTAAGTCGCCTTGCACTATAAGAATAGTTTAACGCGTCAGCTTTTCCAGT
TAAAGATAAAAAGAGACCGAATACGATTCCTGTATTCGGTCCAGGGAAATGGCTCTTGGGAGAGAGCCGTGCGCTAAAAG
TTGGCATTAATGCAGGCTAAGTCGCCTTGCACTATAAGAATAGTTTAACGCGTCAGCTTTTCCAGT
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|