Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | yefM-yoeB (relBE)/YoeB-YefM |
| Location | 769247..769780 | Replicon | chromosome |
| Accession | NZ_CP077403 | ||
| Organism | Jonesia denitrificans strain FDAARGOS 1440 | ||
Toxin (Protein)
| Gene name | yoeB | Uniprot ID | C7QYS0 |
| Locus tag | I6L70_RS03665 | Protein ID | WP_015771937.1 |
| Coordinates | 769526..769780 (+) | Length | 85 a.a. |
Antitoxin (Protein)
| Gene name | yefM | Uniprot ID | C7QYS1 |
| Locus tag | I6L70_RS03660 | Protein ID | WP_015771938.1 |
| Coordinates | 769247..769525 (+) | Length | 93 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| I6L70_RS03620 (I6L70_03620) | 764763..765245 | + | 483 | WP_015771946.1 | pantetheine-phosphate adenylyltransferase | - |
| I6L70_RS03625 (I6L70_03625) | 765315..765827 | + | 513 | WP_015771945.1 | hypothetical protein | - |
| I6L70_RS03630 (I6L70_03630) | 765995..766525 | + | 531 | WP_015771943.1 | DUF177 domain-containing protein | - |
| I6L70_RS03635 (I6L70_03635) | 766528..766722 | + | 195 | WP_015771942.1 | 50S ribosomal protein L32 | - |
| I6L70_RS03640 (I6L70_03640) | 766745..767485 | + | 741 | WP_049754459.1 | ribonuclease III | - |
| I6L70_RS03645 (I6L70_03645) | 767492..768421 | + | 930 | WP_015771940.1 | bifunctional DNA-formamidopyrimidine glycosylase/DNA-(apurinic or apyrimidinic site) lyase | - |
| I6L70_RS03650 (I6L70_03650) | 768432..768953 | - | 522 | WP_226926569.1 | GNAT family N-acetyltransferase | - |
| I6L70_RS12875 | 769015..769119 | - | 105 | Protein_709 | NAD(P)-dependent oxidoreductase | - |
| I6L70_RS03660 (I6L70_03660) | 769247..769525 | + | 279 | WP_015771938.1 | type II toxin-antitoxin system prevent-host-death family antitoxin | Antitoxin |
| I6L70_RS03665 (I6L70_03665) | 769526..769780 | + | 255 | WP_015771937.1 | Txe/YoeB family addiction module toxin | Toxin |
| I6L70_RS03670 (I6L70_03670) | 769922..770554 | - | 633 | WP_231953686.1 | NAD(P)-dependent oxidoreductase | - |
| I6L70_RS03675 (I6L70_03675) | 771036..771659 | + | 624 | WP_015771935.1 | response regulator transcription factor | - |
| I6L70_RS03680 (I6L70_03680) | 771669..772898 | - | 1230 | WP_015771934.1 | histidine kinase | - |
| I6L70_RS03685 (I6L70_03685) | 772940..774721 | - | 1782 | WP_015771933.1 | thiol reductant ABC exporter subunit CydC | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 85 a.a. Molecular weight: 10110.50 Da Isoelectric Point: 6.7175
>T207124 WP_015771937.1 NZ_CP077403:769526-769780 [Jonesia denitrificans]
VRLVWDEAAWEDYKHWQTADRRVLKRINLLIDACLREPFEGIGKPEQLKYGVQGSWSRRINEEHRLVYLVDGDDLVILQA
RYHY
VRLVWDEAAWEDYKHWQTADRRVLKRINLLIDACLREPFEGIGKPEQLKYGVQGSWSRRINEEHRLVYLVDGDDLVILQA
RYHY
Download Length: 255 bp
>T207124 NZ_CP102891:802681-803091 [Klebsiella pneumoniae]
GTGGTCCTGTGGCAATCTGATCTCCGTATCTCCTGGCGCGCGCAGTGGTTTTCCCTGCTGCTTCACGGCGTGGTGGCGGC
CCTGGTGCTGTTGGTTCCCTGGCCGCTGAGCTATACCCCGATCTGGCTGCTGCTGCTGTCGCTGGTGGTCTTCGACTGCG
TGCGCAGCCAGCGGCGGATCCATGCCCGTCGCGGGGAGATAAAACTGCTCACCGATTCCCGTCTTCGCTGGCAAAACGCC
GAATGGGAAATCCTCGGGACGCCGTGGGTTATCAATAGCGGTATGCTGCTGCGTTTGCGCCATGTCGATACCCGGCGCGG
ACAGCATCTTTGGCTGGCGGCGGACAGCATGGACGCCGGAGAGTGGCGCGATCTGCGCCGGCTGGTGCTGCAAAAACCGG
CGCAGGAGTAA
GTGGTCCTGTGGCAATCTGATCTCCGTATCTCCTGGCGCGCGCAGTGGTTTTCCCTGCTGCTTCACGGCGTGGTGGCGGC
CCTGGTGCTGTTGGTTCCCTGGCCGCTGAGCTATACCCCGATCTGGCTGCTGCTGCTGTCGCTGGTGGTCTTCGACTGCG
TGCGCAGCCAGCGGCGGATCCATGCCCGTCGCGGGGAGATAAAACTGCTCACCGATTCCCGTCTTCGCTGGCAAAACGCC
GAATGGGAAATCCTCGGGACGCCGTGGGTTATCAATAGCGGTATGCTGCTGCGTTTGCGCCATGTCGATACCCGGCGCGG
ACAGCATCTTTGGCTGGCGGCGGACAGCATGGACGCCGGAGAGTGGCGCGATCTGCGCCGGCTGGTGCTGCAAAAACCGG
CGCAGGAGTAA
Antitoxin
Download Length: 93 a.a. Molecular weight: 10366.60 Da Isoelectric Point: 5.7185
>AT207124 WP_015771938.1 NZ_CP077403:769247-769525 [Jonesia denitrificans]
MSISASEARKTLFPLIERVNQDHEAIEIVSRKGNAVLMPADEYAAWQETAYLFRSPANARRLLDAYDRARAGKVQAHELD
RSDEPADQPRGI
MSISASEARKTLFPLIERVNQDHEAIEIVSRKGNAVLMPADEYAAWQETAYLFRSPANARRLLDAYDRARAGKVQAHELD
RSDEPADQPRGI
Download Length: 279 bp
>AT207124 NZ_CP102891:802434-802700 [Klebsiella pneumoniae]
ATGGACATTAACAATAAAGCACGTATCCACTGGGCATGCCGCCGCGGGATGCGCGAACTCGACATCTCCATCATGCCGTT
CTTTGAGTATGAGTACGATACCCTCAGCGACGCTGACAAACAGCTGTTCATTCGCCTGCTGGAAAATGACGATCCGGATC
TGTTCAACTGGCTGATGAACCACGGCAAACCGGCCGATGCGGAGCTGCAGCGGATGGTAACCTTAATTCAGACACGGAAT
CGGGAACGTGGTCCTGTGGCAATCTGA
ATGGACATTAACAATAAAGCACGTATCCACTGGGCATGCCGCCGCGGGATGCGCGAACTCGACATCTCCATCATGCCGTT
CTTTGAGTATGAGTACGATACCCTCAGCGACGCTGACAAACAGCTGTTCATTCGCCTGCTGGAAAATGACGATCCGGATC
TGTTCAACTGGCTGATGAACCACGGCAAACCGGCCGATGCGGAGCTGCAGCGGATGGTAACCTTAATTCAGACACGGAAT
CGGGAACGTGGTCCTGTGGCAATCTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|