Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HTH(antitoxin)
Location 968916..969518 Replicon chromosome
Accession NZ_CP077392
Organism Enterobacter hormaechei strain FDAARGOS 1435

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag I6L65_RS04585 Protein ID WP_045308723.1
Coordinates 968916..969227 (+) Length 104 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag I6L65_RS04590 Protein ID WP_032626927.1
Coordinates 969228..969518 (+) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
I6L65_RS04555 (I6L65_04555) 964023..964919 + 897 WP_048966000.1 sugar kinase -
I6L65_RS04560 (I6L65_04560) 964954..965754 + 801 WP_048965999.1 DeoR/GlpR family DNA-binding transcription regulator -
I6L65_RS04565 (I6L65_04565) 965873..966472 + 600 WP_003861947.1 glucose-1-phosphatase -
I6L65_RS04570 (I6L65_04570) 966466..967347 + 882 WP_023298923.1 virulence factor BrkB family protein -
I6L65_RS04575 (I6L65_04575) 967344..967781 + 438 WP_048965998.1 D-aminoacyl-tRNA deacylase -
I6L65_RS04580 (I6L65_04580) 967826..968767 + 942 WP_022649838.1 fatty acid biosynthesis protein FabY -
I6L65_RS04585 (I6L65_04585) 968916..969227 + 312 WP_045308723.1 toxin HigB-2 Toxin
I6L65_RS04590 (I6L65_04590) 969228..969518 + 291 WP_032626927.1 NadS family protein Antitoxin
I6L65_RS04595 (I6L65_04595) 969560..970489 - 930 WP_022649835.1 formate dehydrogenase accessory protein FdhE -
I6L65_RS04600 (I6L65_04600) 970486..971121 - 636 WP_006808711.1 formate dehydrogenase cytochrome b556 subunit -
I6L65_RS04605 (I6L65_04605) 971118..972020 - 903 WP_003861960.1 formate dehydrogenase subunit beta -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 968916..980086 11170


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Cro/C1-type helix-turn-helix domain

(36-85)


Sequences

Toxin        


Download         Length: 104 a.a.        Molecular weight: 12134.10 Da        Isoelectric Point: 9.4455

>T207105 WP_045308723.1 NZ_CP077392:968916-969227 [Enterobacter hormaechei]
MLFIETDIFTEDVKTLLDDDEYHRFQIFLATQPDYGDLIQNSGGLRKIRWLAGGKGKRSGVRVIYFHRTRECEIRLLLIY
RKGIKDDLSAGEKAILKKMIERW

Download         Length: 312 bp

>T207105 NZ_CP102883:c5242820-5242437 [Klebsiella pneumoniae]
ATGACCTCCGGATCTGCGCTTTTTGATACCAATATTCTTATTGATTTATTTAGCGGGCGTCGCGAAGCCAAACAGGCGCT
GGAGGCCTGGCCACCGCAGAATGCGATCAGTCTGATTACCTGGATGGAGGTGATGGTTGGCGCTAAAAAATATCACCAGG
AGCAGCGCACGCGAATGGCGCTGAGCACCTTTAATATCATTAACATCTCACAGGATATTGCAGAGCGAAGCGTTGCGCTG
CGGCAGGAGTATAAGCTTAAGCTGCCGGATGCCATCATTCTGGCGACGGCGCAACTCCATCGTCTGGAACTAATTACGCG
GAATACGAAGGATTTTACCGGTATTCCTGGCGTAGTCACGCCGTACGAAATCCACCCTGAATAA

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10685.18 Da        Isoelectric Point: 10.5888

>AT207105 WP_032626927.1 NZ_CP077392:969228-969518 [Enterobacter hormaechei]
MDKALFERLTQSIAQINEIAEGQREPSRTFQIDAMKIKEIRQASGLSQSKFANLISVSVDTLRNWEQGRRSPTGPAKALL
RAIANDPQHVIPALSQ

Download         Length: 291 bp

>AT207105 NZ_CP102883:c5243062-5242820 [Klebsiella pneumoniae]
ATGATGGCTGAAAGGGATATGGGCAGAATTCTTCTCGATTTATCAGACGATGTCATTCAACGTCTCGATGACCTCAAAGT
GCAGCGTAACATTCCGCGAGCGGAACTGTTACGTGAAGCGGTTGAACAATATCTGGAGAAACAAGATCGAGCTAAAGATA
CCATCTCCAGTGCGCTGGGTCTGTGGCAAGACTGCGAAGAAGACGGCATGGAATATCAACGTCAGCTACGCAAGGAGTGG
TAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References