Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/RelE-HTH
Location 15379..15964 Replicon plasmid unnamed4
Accession NZ_CP077373
Organism Acinetobacter lwoffii strain FDAARGOS 1394

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag I6L24_RS16335 Protein ID WP_216986677.1
Coordinates 15644..15964 (-) Length 107 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag I6L24_RS16330 Protein ID WP_216986676.1
Coordinates 15379..15651 (-) Length 91 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
I6L24_RS16305 (I6L24_16310) 10828..11364 + 537 WP_216986675.1 plasmid replication DNA-binding protein -
I6L24_RS16310 (I6L24_16315) 11647..13101 - 1455 WP_131275007.1 SulP family inorganic anion transporter -
I6L24_RS16315 (I6L24_16320) 13349..13558 - 210 WP_010116191.1 hypothetical protein -
I6L24_RS16320 (I6L24_16325) 13941..14321 + 381 WP_005225409.1 fluoride efflux transporter CrcB -
I6L24_RS16325 (I6L24_16330) 14348..14872 + 525 WP_131275023.1 inorganic diphosphatase -
I6L24_RS16330 (I6L24_16335) 15379..15651 - 273 WP_216986676.1 NadS family protein Antitoxin
I6L24_RS16335 (I6L24_16340) 15644..15964 - 321 WP_216986677.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
I6L24_RS16340 (I6L24_16345) 16109..16708 + 600 WP_216986678.1 hypothetical protein -
I6L24_RS16345 (I6L24_16350) 17154..17345 - 192 WP_004282089.1 YqaE/Pmp3 family membrane protein -
I6L24_RS16350 (I6L24_16355) 17375..17656 - 282 WP_216986680.1 mobilization protein -
I6L24_RS16355 (I6L24_16360) 17866..19302 + 1437 WP_216986679.1 MobQ family relaxase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..19982 19982


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-2

(41-102)

Antitoxin

Cro/C1-type helix-turn-helix domain

(37-85)


Sequences

Toxin        


Download         Length: 107 a.a.        Molecular weight: 12208.07 Da        Isoelectric Point: 9.3987

>T207096 WP_216986677.1 NZ_CP077373:c15964-15644 [Acinetobacter lwoffii]
MLFIETSIFTKQIKELVSDKEYRQLQQDLLVQPDKGDLIKNGGGIRKVRCAQGNKGKSGGIRVIYYWVTEDDQIFFLVAY
PKSVKDNLTDKETSILRQLVKEQFHG

Download         Length: 321 bp

>T207096 NZ_CP102883:730931-731416 [Klebsiella pneumoniae]
ATGATCTCGGCACCAGAACCGCTTCATGCCGGGCATATTCTTACCCCGTTTTGCTGCGGTATAGATTCCATGGATCACTG
GCTGAAACAGCGGGCGATGAAAAATCAGGTTACTGGCGCATCCCGCACCTTTGTCTGCTGCGACGACGCGAAGGTGATGG
CTTACTACTCACTGGCTTCCAGCGCTGTGACGACAAATACTGCGCCGGGTCGTTTTCGCCGCAATATGCCTGCCCCGATC
CCGGTTGTGGTACTGGGTCGTCTGGCGGTGGATAAATCACTACATGGGAAAGGTGTCGGGCGGGCCCTGGTACGTGATGC
CGGGCTGCGTGTGATTCAGGTGGCGGAGACTATCGGCATTCGCGGGATGCTGGTTCACGCCCTGTCGGATGAAGCACGGG
ATTTTTACCTGCGGGTGGGGTTTGAGCCGTCGCCGATGGATCCGATGATGTTGATGGTGACGTTGAGGGATTTGGTTAAT
GCCTGA

Antitoxin


Download         Length: 91 a.a.        Molecular weight: 10081.53 Da        Isoelectric Point: 7.2045

>AT207096 WP_216986676.1 NZ_CP077373:c15651-15379 [Acinetobacter lwoffii]
MDNSLFDDLVASIKEAGAIKRNEIKASRVTELELPDIKEVREKTGLTQAEFAARLHISARTLQNWEQGRRYPTGPAATLI
RILDAHPTLI

Download         Length: 273 bp

>AT207096 NZ_CP102883:730641-730934 [Klebsiella pneumoniae]
ATGCCAGCCGCAAACAGCATGTCCATAAAACGCGAAACGTTAAATCTGCGCATTAAACCTGCCGAACGCGATCTTATTGA
TCGGGCGGCGAAAGCCAGAGGGAAAAACCGCACAGACTTTGTGCTGGAGGCCGCCCGCGCTGCCGCTGAGGAAGCGCTGA
TTGAGCAACGCATCATTATGGCCGATCCGCAGGCTTATCAGGAATTTCTCGCTCGTCTGGATCAGGCTCCTGCACCTAAT
GCCGCACTGCGTAAAACTATGCAGACCCCTGCGCCGTGGGAACAGGAAGAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References