Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 42020..42671 Replicon plasmid unnamed1
Accession NZ_CP077370
Organism Acinetobacter lwoffii strain FDAARGOS 1394

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag I6L24_RS15500 Protein ID WP_216986649.1
Coordinates 42315..42671 (-) Length 119 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag I6L24_RS15495 Protein ID WP_096902776.1
Coordinates 42020..42322 (-) Length 101 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
I6L24_RS15470 (I6L24_15475) 38022..39389 - 1368 WP_004281854.1 TolC family protein -
I6L24_RS15475 (I6L24_15480) 39439..39849 - 411 WP_004733191.1 hypothetical protein -
I6L24_RS15480 (I6L24_15485) 39991..40383 - 393 WP_004281856.1 Cd(II)/Pb(II)-responsive transcriptional regulator -
I6L24_RS15485 (I6L24_15490) 40473..41753 + 1281 WP_184413650.1 cation transporter -
I6L24_RS15490 (I6L24_15495) 41817..41978 + 162 Protein_48 IS6 family transposase -
I6L24_RS15495 (I6L24_15500) 42020..42322 - 303 WP_096902776.1 XRE family transcriptional regulator Antitoxin
I6L24_RS15500 (I6L24_15505) 42315..42671 - 357 WP_216986649.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
I6L24_RS15505 (I6L24_15510) 43307..44284 + 978 WP_004761028.1 TerC family protein -
I6L24_RS15510 (I6L24_15515) 44682..45385 + 704 Protein_52 IS6-like element IS1008 family transposase -
I6L24_RS15515 (I6L24_15520) 45514..45801 + 288 WP_216986650.1 BrnT family toxin -
I6L24_RS15520 (I6L24_15525) 45788..46102 + 315 WP_216986651.1 BrnA antitoxin family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..121296 121296
- inside IScluster/Tn - - 41817..45385 3568


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(12-105)

Antitoxin

HigA2-like, helix-turn-helix domain

(14-89)


Sequences

Toxin        


Download         Length: 119 a.a.        Molecular weight: 13640.66 Da        Isoelectric Point: 7.1651

>T207092 WP_216986649.1 NZ_CP077370:c42671-42315 [Acinetobacter lwoffii]
MWTVITTDLFNQWLEQQDEPTQEKVLTALVVLQQQGPSLGRPLVDTVYESKFTNMKELRVQHRGRPLRAFFAFDPLRQAI
VLCIADKGGKKRFYKDMLDIADEQYQLHLTTLGDKSNG

Download         Length: 357 bp

>T207092 NZ_CP102879:48579-48995 [Klebsiella pneumoniae]
GTGAACAAGACCTATATGCTCGACACCTGTATCTGCTCGTTCATCATGCGCGAGCAGCCGGAAGCCGTCCTGAAGCGCCT
GGAGCAGGCGGTGCTGCGCGGCCAGCGCATCGTTGTCTCGGCCATCACTTATTCTGAAATGCGCTTCGGGGCCACCGGCC
CGAAGGCCTCCCCGCGCCACGTCGAGCTGGTCGACGCGTTCTGCGCCCGCCTCGATGCCATCCTGCCCTGGGATCGCGCT
GCGGTGGACGCCACCACGGAGATTAAGGTGGCGCTGCGAATGGCCGGGACGCCGATCGGCCCGAACGACACGGCCATTGC
CGGGCACGCCATCGCCGCCGGTGCCGTGCTGGTGACGAATAATACGCGGGAATTTGAGCGGGTACCGGGTCTTGTGCTGG
AAGACTGGGTAAGATAA

Antitoxin


Download         Length: 101 a.a.        Molecular weight: 11241.09 Da        Isoelectric Point: 7.2052

>AT207092 WP_096902776.1 NZ_CP077370:c42322-42020 [Acinetobacter lwoffii]
MAKTLQELLASRSPESQARIQKMADELLLENQLHLIREELEISQKELAETLGIKQPSLSAIENRGNDLKISTMKKYVEAM
GGKLRIDVELPTGKHIGFKV

Download         Length: 303 bp

>AT207092 NZ_CP102879:48352-48582 [Klebsiella pneumoniae]
ATGAGAACTGTATCCATTTTTAAAAACGGCAATAACCGCGCCATTCGTCTGCCCCGCGATCTGGATTTTGAGGGAGTGAG
CGAGCTGGAGATCGTCCGGGAAGGGGACAGCATTATTTTGCGTCCCGTCCGGCCGACCTGGGGCTCGTTCGCGCAGTTCG
AGAAGGCAGACCCGGACTTTATGGCGGAGCGCGAGGACGTTGTCAGCGACGAAGGACGATTTAACCTGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References