Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 381405..382126 Replicon plasmid unnamed2
Accession NZ_CP077368
Organism Pantoea agglomerans strain FDAARGOS 1447

Toxin (Protein)


Gene name higB Uniprot ID A0A8X8J2A8
Locus tag I6L77_RS21130 Protein ID WP_010247063.1
Coordinates 381815..382126 (-) Length 104 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag I6L77_RS21125 Protein ID WP_010247064.1
Coordinates 381405..381818 (-) Length 138 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
I6L77_RS21100 (I6L77_21095) 377796..378530 - 735 WP_010247068.1 GntR family transcriptional regulator -
I6L77_RS21105 (I6L77_21100) 378831..379070 + 240 WP_140417618.1 hypothetical protein -
I6L77_RS21110 (I6L77_21105) 379106..379555 + 450 WP_033760508.1 PTS sugar transporter subunit IIA -
I6L77_RS21115 (I6L77_21110) 379604..379876 + 273 WP_010247066.1 PTS sugar transporter subunit IIB -
I6L77_RS21120 (I6L77_21115) 379916..381289 + 1374 WP_088234220.1 PTS ascorbate transporter subunit IIC -
I6L77_RS21125 (I6L77_21120) 381405..381818 - 414 WP_010247064.1 helix-turn-helix domain-containing protein Antitoxin
I6L77_RS21130 (I6L77_21125) 381815..382126 - 312 WP_010247063.1 type II toxin-antitoxin system HigB family toxin Toxin
I6L77_RS21135 (I6L77_21130) 382567..384120 + 1554 WP_062758874.1 aspartate aminotransferase family protein -
I6L77_RS21140 (I6L77_21135) 384131..385423 + 1293 WP_062758876.1 lysine N(6)-hydroxylase/L-ornithine N(5)-oxygenase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - hcp/tssD / iroN 1..511735 511735


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, mRNA interferase HigB

(20-93)

Antitoxin

Cro/C1-type helix-turn-helix domain

(82-135)


Sequences

Toxin        


Download         Length: 104 a.a.        Molecular weight: 12207.12 Da        Isoelectric Point: 9.8340

>T207090 WP_010247063.1 NZ_CP077368:c382126-381815 [Pantoea agglomerans]
MHIISRGPFREAAIIYPNHASALDAAYLVLRDENFATPDALKIRFQSLDRMKYREKWWVIDVGGNSLRIMFYADFDRGKI
FIKHIVTHAEYDKLVKKYRESKE

Download         Length: 312 bp

>T207090 NZ_CP102878:c90229-89747 [Klebsiella pneumoniae]
ATGGGAATGAGAGCGCCTGAATCCCTGACGGCTGAACATAACATCGCTGAGTTCTGCTGCCAGGAGCCTGCCCTTAATGA
GTGGTTAAAGAAGAAGGCTCTCAGAAACCACAGTACCGGCATTTCCCGTGTCTATGTCGTCTGCGCAGAAAACACTAACC
GGGTCATCGGTTATTATTGTTTATCTTCGGGTAGCGTCCACCGTAACACAGTGCCTGGGGCCTATAGACGCAACGCGCCT
GATGTCATTCCAGTCATTGTTTTGGGACGGCTTGCCATCGACCAGGCCTGGGCCGGGAATGGGCTTGGTGCCGCACTTCT
TAAGGATGCTATATACCGTACGCAAAACATAGCCTTTCAGGTCGGGGTGAGAGCACTGGCCGTGCATGCGCTGAATGAAG
AAGTTAAATGTTTTTACACCCGTTTTGGCTTTGAGCCTTCCATAGTCAACACGCTGACATTGTTATTCCCGATAAAAGTC
TGA

Antitoxin


Download         Length: 138 a.a.        Molecular weight: 15402.41 Da        Isoelectric Point: 4.9795

>AT207090 WP_010247064.1 NZ_CP077368:c381818-381405 [Pantoea agglomerans]
MITEAIQATNDLVRIVPFLGGSTDKRDYEQALELVEYLVEHQPDSPLVEILSDKVARYENSAPEFAAFNARTDAIPRGVA
LLRVIMDQHGLTQSSFADEIGQRSYVSRILRGDRPLTDKHKARLAARFNLPFEAFAE

Download         Length: 414 bp

>AT207090 NZ_CP102878:c90498-90220 [Klebsiella pneumoniae]
ATGAAACCAGACGTTCGTGAAGCTCCGATTAATATCCGGGCCAAAACATCACAGCGTGACCTGATCGACATGGCCGCAAG
CCTGGTCTCAAAATCACGGACTGATTTTATGCTTGAGGTTGCCTGCAGGGAGGCACAGGACATTCTGCTTGATCAACGCC
TGTTCCTCCTCAATGACAATCAGTTTGAGGCGTTTATTGAAGAGCTTGACGCCCCAATAACGCCGGAGCGCCAGGCGCGA
ATCGATAACCTGATGAACCGCAAATCACCATGGGAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References