Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-YefM
Location 3995..4497 Replicon plasmid unnamed1
Accession NZ_CP077367
Organism Pantoea agglomerans strain FDAARGOS 1447

Toxin (Protein)


Gene name yoeB Uniprot ID A0A8X8DPE2
Locus tag I6L77_RS18545 Protein ID WP_010256862.1
Coordinates 4243..4497 (+) Length 85 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID A0A349IE86
Locus tag I6L77_RS18540 Protein ID WP_010256861.1
Coordinates 3995..4246 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
I6L77_RS18530 (I6L77_18525) 1490..2803 + 1314 WP_031292261.1 CitMHS family transporter -
I6L77_RS18535 (I6L77_18530) 2971..3810 + 840 WP_062759537.1 MBL fold metallo-hydrolase -
I6L77_RS18540 (I6L77_18535) 3995..4246 + 252 WP_010256861.1 YoeB-YefM toxin-antitoxin system antitoxin YefM Antitoxin
I6L77_RS18545 (I6L77_18540) 4243..4497 + 255 WP_010256862.1 Txe/YoeB family addiction module toxin Toxin
I6L77_RS18550 (I6L77_18545) 4553..7099 - 2547 WP_062759536.1 excinuclease ABC subunit UvrA -
I6L77_RS18555 (I6L77_18550) 7763..8221 + 459 WP_031292265.1 hypothetical protein -
I6L77_RS18560 (I6L77_18555) 8215..8508 + 294 WP_022624214.1 DUF1493 family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Mobilizable plasmid - - 1..180597 180597


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(5-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-73)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 9782.16 Da        Isoelectric Point: 9.3799

>T207086 WP_010256862.1 NZ_CP077367:4243-4497 [Pantoea agglomerans]
VKLTWSAEAWEDYLYWQDADKKTVKKINELLKDASRTPFEGKGKPEPLKHNLAGFWSRRITAEHRLVYAVSGDALLIASC
RYHY

Download         Length: 255 bp

>T207086 NZ_CP102877:c4921030-4920113 [Klebsiella pneumoniae]
ATGGATATACAGGCGCCTTATTATCGGCAGGTTGCTCTGCTAATGCAGGTTTTACCCTATGTTGCTGTCGAACGGGAATT
TGCGCTGAAAGGTGGCACTGCCATCAATCTCTTTATCCGCGATTTCCCTCGATTATCGGTGGATATCGACCTCGCCTGGG
TGCCCCTGGAAAGCAGAGCCATCGCTTTACCTCATATACGGGATGCGCTTGCACGTATTGCCGCCAATCTGCAACAACAG
GCAGGTATGAGCGCTGTATTACAAGCTAATCGTTCAGATGAGATGCGTGTCATTGTTACTACCGATAGCGCGCAAATAAA
GATAGAGGTTTCACCGGTCGCCCGGGGAACATTATATCCACCACAGGAGCGAGAAGTGGTGGGGGCGGTAGAGGACGTTT
TTGGCTATGCCAGCCTTCCAGTGGTTTCGTTGCCTGACCTCTACGGTGGAAAATTATGCGCGGCGCTGGATCGCCAGCAT
CCCAGAGATTTTTATGACGTGAAATTACTTCTTGATGCGCAGGAGCTTGACCGTCCCATTTTCAATGGGTTTATCGTGTA
TTTACTGAGCCATAATCGGCCTCTGGCTGAAGTGCTGAATCCTCGCTGGAAAGATATTGCTGAACCTTTTTACCGTGAAT
TCAGCGGGATGACATTTGAGACGATAGCCCTGGAGGAACTGACAGCAGTCCCCAACAGGATGATTGCTGCGTTAAAATCC
TGTTTCACACAACAGGATGTCGATTTTTTACTGTCATTTAAACGAGGCGAACCAGACTGGCGTTTAGCGCCGGAAATGCG
TATTCAGGATTTGCCTGCCGTGCAGTGGAAATTGCGCAATATTCATCAGATGCCAGCGATAAAACGCGCTGAGTCATTAG
ATAAACTGGAAAAGGTGCTGGCCGAGTGGCGCAGTTAG

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9339.48 Da        Isoelectric Point: 4.4155

>AT207086 WP_010256861.1 NZ_CP077367:3995-4246 [Pantoea agglomerans]
MRAISYSEARQNLSATMVQTVEDKAPVLITRQNGESCVLMSLEEYNSLEETAYLLRSPKNARRLMDSIESLQSGNGTDRD
IIE

Download         Length: 252 bp

>AT207086 NZ_CP102877:c4921794-4921036 [Klebsiella pneumoniae]
ATGGCAACAAAATTAAACTGGCTGCTGCAAAACAGCGCTCCCGGAGATGTGATCCTTCAGTCCTGGTTAAGCCAGCATGC
CATCTCTCCCTCTCTGGCCTTTAAATACGCGCAAAGTGGCTGGTTAAAAAAAAGAGGCAACGGCGTATATGCGCGTGCGG
GACGTGAGCCGGAGTGGAACGATGCATTTGCATGTTTGCAAAATCAGCTTGCCGCTCCGGTGTATGTTGCGGGGCTCAGT
AGCTTAGTCTGGCAGGGCCGTTCACACTATCTACAGCTAAAACAAAACCAGTGCTGGCTTAGTGTGGAAAATAAAGCGCT
GCTGCCGAAATGGTTCAGGGAATTCCCGGGTGTGGAGTGGATAGTCATATCGGGGAAAAAACTGCCGGTGCTGGATGATA
GATACCGTGTAACGCTTGATATAAAAGGGAAAAAACTCATCGGCAGTGCGCCAGAACTGGCTGCTTACGAGTTGCTGAGC
GCGGTGCCGGGGACCCTCTCATTTAACCACGCTGCAGAGCTTTTCCAGGGGCTGGTTAATCTTAATCCTCGTAAAGTAGA
GTATCTTCTTTCCGTCAGCCAGTCCGTGCAGGCCAAGCGTTTGTATCTCTTCTTCGCCAGTTTTTACGAGCATGGCTGGC
TCAAACGAATCGATAGCCAAAAAATCGATCTGGGAGCGGGCAAGCGGCAAATCGTGGAAAATGGAAAGTTCAATGCTCAA
TACCAAATCACAGTGCCTGAACGCTTTCAAAAGGAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A349IE86

References