Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 3141396..3142041 Replicon chromosome
Accession NZ_CP077331
Organism Lelliottia amnigena strain FDAARGOS 1446

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag I6L76_RS15200 Protein ID WP_216981890.1
Coordinates 3141396..3141758 (+) Length 121 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag I6L76_RS15205 Protein ID WP_202694508.1
Coordinates 3141742..3142041 (+) Length 100 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
I6L76_RS15155 (I6L76_15155) 3136397..3137218 + 822 WP_213813332.1 DUF932 domain-containing protein -
I6L76_RS15160 (I6L76_15160) 3137288..3137758 + 471 WP_216980689.1 DNA repair protein RadC -
I6L76_RS15165 (I6L76_15165) 3137767..3137988 + 222 WP_216980690.1 DUF987 family protein -
I6L76_RS15170 (I6L76_15170) 3138020..3138385 + 366 WP_216980691.1 type IV toxin-antitoxin system YeeU family antitoxin -
I6L76_RS15175 (I6L76_15175) 3138419..3138739 + 321 WP_216980692.1 TA system toxin CbtA family protein -
I6L76_RS15180 (I6L76_15180) 3139141..3139701 + 561 WP_216980693.1 toll/interleukin-1 receptor domain-containing protein -
I6L76_RS15185 (I6L76_15185) 3139754..3140590 + 837 WP_216980694.1 DUF6430 domain-containing protein -
I6L76_RS15190 (I6L76_15190) 3140604..3140795 - 192 WP_032634623.1 toxin-antitoxin system HicB family antitoxin -
I6L76_RS15195 (I6L76_15195) 3140921..3141211 + 291 WP_216980695.1 SymE family type I addiction module toxin -
I6L76_RS15200 (I6L76_15200) 3141396..3141758 + 363 WP_216981890.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
I6L76_RS15205 (I6L76_15205) 3141742..3142041 + 300 WP_202694508.1 XRE family transcriptional regulator Antitoxin
I6L76_RS15210 (I6L76_15210) 3142110..3143108 - 999 WP_216980696.1 class I SAM-dependent methyltransferase -
I6L76_RS15215 (I6L76_15215) 3143202..3143726 - 525 WP_059180518.1 lipocalin family protein -
I6L76_RS15220 (I6L76_15220) 3143952..3144680 + 729 WP_216980697.1 MerR family transcriptional regulator -
I6L76_RS15225 (I6L76_15225) 3144778..3145188 + 411 WP_059180520.1 hydroxyisourate hydrolase -
I6L76_RS15230 (I6L76_15230) 3145350..3146309 + 960 WP_059180521.1 DUF523 and DUF1722 domain-containing protein -
I6L76_RS15235 (I6L76_15235) 3146493..3146909 - 417 WP_131487776.1 Imm63 family immunity protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 3119395..3164320 44925


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(12-105)

Antitoxin

Cro/C1-type helix-turn-helix domain

(32-80)


Sequences

Toxin        


Download         Length: 121 a.a.        Molecular weight: 14253.38 Da        Isoelectric Point: 7.3572

>T207060 WP_216981890.1 NZ_CP077331:3141396-3141758 [Lelliottia amnigena]
MWTVLLGHVFEQWLYEQDEGLQEKVFVDLLNLQNYGPHLARPWVDTVKGSRHKNMKELRIQYSGRPIRAFFAFDPIRQAI
MLCAGDKRGDKMFYERLIRIADEEFSIHLATWGQQNENLK

Download         Length: 363 bp

>T207060 NZ_CP102869:352066-352413 [Klebsiella pneumoniae]
ATGTGGGATGTAGAAACGACGGATACGTTTGATACCTGGTTCGAATTACAAAGTAGAGCTTTAAAAGAGGATATGTTGGC
CACGATTCTCATCCTGTCTGAGTTTGCTCCGCAGCTTGGGCGCCCGTATGTTGATACGGTGAAAGATTCAACGTTTCAGA
ATATGAAAGAACTCCGGGTTCAGCATCATGGGCTCCCCATCCGCGCCTTTTTTGCTTTTGATCCTCTGCGGAAAGCTATC
GTTTTATGTGCGGGCGATAAGGATGGCATGAATGAGAAACGTTTTTACAAAGAGATGATTACTCTGGCTGACAGAGAATT
CAGCCAACACCTGACTAAGGAGCGATAA

Antitoxin


Download         Length: 100 a.a.        Molecular weight: 11126.10 Da        Isoelectric Point: 9.7256

>AT207060 WP_202694508.1 NZ_CP077331:3141742-3142041 [Lelliottia amnigena]
MKTLNEVIASRSPESQKRIKEMADEMILETGLQMMREELKLSQKAVAELMGISQPAVTQLEQRGNELKIATLKRYIEAMG
GKLSLNVELPTGKRVAFHI

Download         Length: 300 bp

>AT207060 NZ_CP102869:352413-352712 [Klebsiella pneumoniae]
ATGGCCACGCTAAAAGAACTCATGGCGAAACAGAGTCCTGAAAGCCAGCAGCGTATTGCAGCGAAAGCGGCAGAGATACG
CCAGTCTGTCGCTTTAAACTTGCTTCGAGAAGAGTTGCAAATGTCGCAAACAGAGATGGCTGCGGCTATGGGGGTAAAGC
AGCCAACGATCGCTAAAATGGAACAGACTGATAACGACCCTCGGCTTTCGACCCTAAAACGCTACATTGCGGCATTGGGG
GGAGAACTCAGTATAAATGTCACATTGCCGACTGGAAAAAAAGTCTCGTTTAATTTGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References