Detailed information of TA system TA207057

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): higBA (relBE)/HigB-HigA
• Location: 2855204..2855931
• Replicon: chromosome
• Accession: NZ_CP077331
• Organism: Lelliottia amnigena strain FDAARGOS 1446

Toxin (Protein)

• Gene name: higB
• Uniprot ID: -
• Locus tag: I6L76_RS13810
• Protein ID: WP_131486857.1
• Coordinates: 2855204..2855515 (+)
• Length: 104 a.a.

Antitoxin (Protein)

• Gene name: higA
• Uniprot ID: -
• Locus tag: I6L76_RS13815
• Protein ID: WP_174342747.1
• Coordinates: 2855512..2855931 (+)
• Length: 140 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
I6L76_RS13780 (I6L76_13780)	2850728..2851483	+	756	WP_202694602.1	phosphonate C-P lyase system protein PhnK	-
I6L76_RS13785 (I6L76_13785)	2851493..2852173	+	681	WP_216980601.1	phosphonate C-P lyase system protein PhnL	-
I6L76_RS13790 (I6L76_13790)	2852170..2853306	+	1137	WP_216980602.1	alpha-D-ribose 1-methylphosphonate 5-triphosphate diphosphatase	-
I6L76_RS13795 (I6L76_13795)	2853303..2853860	+	558	WP_174342797.1	ribose 1,5-bisphosphokinase	-
I6L76_RS13800 (I6L76_13800)	2853847..2854281	+	435	WP_059179880.1	aminoalkylphosphonate N-acetyltransferase	-
I6L76_RS13805 (I6L76_13805)	2854291..2855049	+	759	WP_216980603.1	phosphonate metabolism protein PhnP	-
I6L76_RS13810 (I6L76_13810)	2855204..2855515	+	312	WP_131486857.1	type II toxin-antitoxin system HigB family toxin	Toxin
I6L76_RS13815 (I6L76_13815)	2855512..2855931	+	420	WP_174342747.1	helix-turn-helix domain-containing protein	Antitoxin
I6L76_RS13820 (I6L76_13820)	2856965..2857078	+	114	Protein_2710	phosphonate metabolism protein PhnP	-
I6L76_RS13825 (I6L76_13825)	2857150..2857635	+	486	WP_216980604.1	hypothetical protein	-
I6L76_RS13830 (I6L76_13830)	2857700..2858023	-	324	WP_216980605.1	DDRRRQL repeat protein YjdP	-
I6L76_RS13835 (I6L76_13835)	2858093..2860375	-	2283	WP_216980606.1	ATP-binding protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, mRNA interferase HigB (22-93)

Antitoxin

• Cro/C1-type helix-turn-helix domain (85-138)

Sequences

Toxin

Protein

• Length: 104 a.a.
• Molecular weight: 12423.23 Da
• Isoelectric Point: 9.5047

>T207057 WP_131486857.1 NZ_CP077331:2855204-2855515 [Lelliottia amnigena]
MHVISKEPFEEAAKHYPNDSLALLALYRLLRETDFISPTELRTLIPSLDNFKYRSKWWVIDVGGNNLRIVAYINFVNKRF
YVKHIVTHSEYDKLNRYYRENKE

Nucleotide

• Length: 312 bp

>T207057 NZ_CP102866:482488-482838 [Bacillus velezensis]
TTGATTGTAAAGCGCGGCGATGTTTATTTTGCTGATTTATCTCCTGTTGTTGGCTCAGAGCAAGGCGGCGTACGCCCGGT
TTTAGTGATCCAAAATGATATCGGAAATCGCTTTAGCCCGACTGCTATTGTTGCAGCCATAACAGCCCAAATACAGAAAG
CGAAATTACCAACCCACGTCGAAATTGATGCAAAACGCTACGGTTTTGAAAGAGATTCCGTTATTTTGCTGGAGCAAATT
CGGACGATTGACAAGCAAAGATTAACGGATAAAATAACTCATCTGGATGATGAAATGATGGATAAGGTTGATGAAGCCTT
GCAAATCAGTTTGGCACTCATTGATTTTTAG

Antitoxin

Protein

• Length: 140 a.a.
• Molecular weight: 15431.47 Da
• Isoelectric Point: 4.4202

>AT207057 WP_174342747.1 NZ_CP077331:2855512-2855931 [Lelliottia amnigena]
MIANTARAIEATKQLVDAVPFLGGSSSESDYREALALVDYLIENDDENPLIDFLASKIADYENNSDRFAEFNKSVAEMPV
GVALLRTLIDQYKLSYADLKEEIGSKSLVSQILSGQRSLTITHIKALSARFGVRPEWFL

Nucleotide

• Length: 420 bp

>AT207057 NZ_CP102866:482201-482482 [Bacillus velezensis]
TTGTCTGAATCCAGCGCAAGAACCGAAATGAAAATCAGCTTGCCTGAAAACTTAGTAGCTGAATTGGATGGTGTAGCGAT
GCGGGAGAAACGAAGCAGAAACGAACTGATATCACAAGCAGTGAGAGCGTATGTCAGCGAACGGACAACTCGCCATAACC
GTGATTTGATGAGACGCGGGTATATGGAAATGGCGAAAATCAACTTGAATATCTCTTCTGAGGCTCACTATGCTGAGTGC
GAAGCAGAAACGACCGTTGAGCGCTTAGTCAGCGGAGGATAA