Detailed information of TA system TA207045

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): DinJ-YafQ (relBE)/YafQ-RelB
• Location: 97924..98456
• Replicon: plasmid unnamed1
• Accession: NZ_CP077318
• Organism: Providencia rettgeri strain FDAARGOS 1450

Toxin (Protein)

• Gene name: yafQ
• Uniprot ID: -
• Locus tag: I6L80_RS21235
• Protein ID: WP_115168364.1
• Coordinates: 98181..98456 (+)
• Length: 92 a.a.

Antitoxin (Protein)

• Gene name: dinJ
• Uniprot ID: -
• Locus tag: I6L80_RS21230
• Protein ID: WP_282561812.1
• Coordinates: 97924..98187 (+)
• Length: 88 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
I6L80_RS21200 (I6L80_21200)	93223..94441	+	1219	Protein_89	IS3 family transposase	-
I6L80_RS21205 (I6L80_21205)	94728..94940	+	213	WP_115168369.1	RNA chaperone/antiterminator CspA	-
I6L80_RS21210 (I6L80_21210)	95208..95519	-	312	WP_115168368.1	type II toxin-antitoxin system MqsA family antitoxin	-
I6L80_RS21215 (I6L80_21215)	95512..95856	-	345	WP_115168367.1	toxin	-
I6L80_RS21220 (I6L80_21220)	96184..96765	-	582	WP_282561811.1	hypothetical protein	-
I6L80_RS21225 (I6L80_21225)	97121..97750	+	630	WP_217007959.1	recombinase family protein	-
I6L80_RS21230 (I6L80_21230)	97924..98187	+	264	WP_282561812.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	Antitoxin
I6L80_RS21235 (I6L80_21235)	98181..98456	+	276	WP_115168364.1	type II toxin-antitoxin system YafQ family toxin	Toxin
I6L80_RS21240 (I6L80_21240)	98669..99061	+	393	WP_115168363.1	hypothetical protein	-
I6L80_RS21245 (I6L80_21245)	99251..99640	-	390	WP_115168362.1	hypothetical protein	-
I6L80_RS21250 (I6L80_21250)	99932..100138	-	207	WP_254178935.1	hypothetical protein	-
I6L80_RS21255 (I6L80_21255)	100193..100555	+	363	Protein_100	IS6 family transposase	-
I6L80_RS21260 (I6L80_21260)	100606..101300	-	695	Protein_101	IS1 family transposase	-
I6L80_RS21265 (I6L80_21265)	101328..101600	-	273	WP_115168361.1	hypothetical protein	-
I6L80_RS21270 (I6L80_21270)	101682..101837	+	156	WP_217007960.1	hypothetical protein	-
I6L80_RS21275 (I6L80_21275)	102142..102363	+	222	WP_217007961.1	hypothetical protein	-
I6L80_RS21280 (I6L80_21280)	102519..102659	+	141	WP_254178936.1	helix-turn-helix domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Non-Mobilizable plasmid	-	-	1..108549	108549

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, YafQ-like toxin (7-88)

Antitoxin

• RelB antitoxin/Antitoxin DinJ (1-84)

Sequences

Toxin

Protein

• Length: 92 a.a.
• Molecular weight: 10650.34 Da
• Isoelectric Point: 9.9690

>T207045 WP_115168364.1 NZ_CP077318:98181-98456 [Providencia rettgeri]
MLTPIRSSTFKADVKRQKKRGKDLNKLKVLIELLIKEEQIPADYVDHPLIGNWRGYRDAHIEGDWLLIYKITGQELKLAR
TGSHQDIFSQY

Nucleotide

• Length: 276 bp

>T207045 NZ_CP102853:c4222145-4221972 [Escherichia coli]
ATGGCACTATTCTCTAAAATATTAATTTTTTATGTGATTGGTGTGAACATATCCTTTGTCATTATCTGGTTTATCTCACA
TGAGAAAACACATATTCGTTTACTTAGTGCATTCCTGGTCGGAATAACCTGGCCAATGAGTCTGCCTGTGGCATTACTTT
TTTCTCTCTTTTAG

Antitoxin

Protein

• Length: 88 a.a.
• Molecular weight: 9332.83 Da
• Isoelectric Point: 5.8270

>AT207045 WP_282561812.1 NZ_CP077318:97924-98187 [Providencia rettgeri]
MISDTTVKARISHDVKERAVSALAKMGLNTSDLIRMVMIRVADEGKLPFDIKTPNVVTKEAIEELEKGNGKALSSTNALF
DDLGIC

Nucleotide

• Length: 264 bp

>AT207045 NZ_CP102853:c4222469-4222173 [Escherichia coli]
ATGGAAGGTAAAAACAAGTTCAATACTTATGTTGTTTCTTTTGATTATCCATCATCTTATTCCTCAGTGTTCTTAAGGTT
AAGATCATTGATGTATGATATGAATTTCTCTTCTATCGTGGCTGATGAATATGGGATACCACGACAATTGAATGAAAATT
CTTTCGCAATAACGACATCGTTAGCCGCAAGTGAAATCGAAGATTTAATCAGGCTTAAATGCTTAGACTTACCGGATATT
GATTTTGACCTCAACATTATGACAGTTGATGACTATTTCCGTCAGTTTTACAAGTAG