Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/MqsA(antitoxin)
Location 95208..95856 Replicon plasmid unnamed1
Accession NZ_CP077318
Organism Providencia rettgeri strain FDAARGOS 1450

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag I6L80_RS21215 Protein ID WP_115168367.1
Coordinates 95512..95856 (-) Length 115 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag I6L80_RS21210 Protein ID WP_115168368.1
Coordinates 95208..95519 (-) Length 104 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
I6L80_RS21180 (I6L80_21180) 90710..90973 + 264 WP_115168371.1 type II toxin-antitoxin system ParD family antitoxin -
I6L80_RS21185 (I6L80_21185) 90954..91256 + 303 WP_115168370.1 type II toxin-antitoxin system RelE/ParE family toxin -
I6L80_RS21190 (I6L80_21190) 91694..92260 - 567 Protein_87 transcriptional regulator -
I6L80_RS21195 (I6L80_21195) 92310..93014 + 705 Protein_88 IS6 family transposase -
I6L80_RS21200 (I6L80_21200) 93223..94441 + 1219 Protein_89 IS3 family transposase -
I6L80_RS21205 (I6L80_21205) 94728..94940 + 213 WP_115168369.1 RNA chaperone/antiterminator CspA -
I6L80_RS21210 (I6L80_21210) 95208..95519 - 312 WP_115168368.1 type II toxin-antitoxin system MqsA family antitoxin Antitoxin
I6L80_RS21215 (I6L80_21215) 95512..95856 - 345 WP_115168367.1 toxin Toxin
I6L80_RS21220 (I6L80_21220) 96184..96765 - 582 WP_282561811.1 hypothetical protein -
I6L80_RS21225 (I6L80_21225) 97121..97750 + 630 WP_217007959.1 recombinase family protein -
I6L80_RS21230 (I6L80_21230) 97924..98187 + 264 WP_282561812.1 type II toxin-antitoxin system RelB/DinJ family antitoxin -
I6L80_RS21235 (I6L80_21235) 98181..98456 + 276 WP_115168364.1 type II toxin-antitoxin system YafQ family toxin -
I6L80_RS21240 (I6L80_21240) 98669..99061 + 393 WP_115168363.1 hypothetical protein -
I6L80_RS21245 (I6L80_21245) 99251..99640 - 390 WP_115168362.1 hypothetical protein -
I6L80_RS21250 (I6L80_21250) 99932..100138 - 207 WP_254178935.1 hypothetical protein -
I6L80_RS21255 (I6L80_21255) 100193..100555 + 363 Protein_100 IS6 family transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..108549 108549


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Cro/C1-type helix-turn-helix domain

(44-87)


Sequences

Toxin        


Download         Length: 115 a.a.        Molecular weight: 13474.53 Da        Isoelectric Point: 9.9755

>T207044 WP_115168367.1 NZ_CP077318:c95856-95512 [Providencia rettgeri]
MKALFVELPAFERYRESYLTDDEFRSFQLMLLKNPLCGDVIQQTGGLRKVRFSDSKRNKGKRGGTRIIYYWYLEKSQFLL
FTIYGKSIADDLTTSQREQLSKMLDIIKKRSNDD

Download         Length: 345 bp

>T207044 NZ_CP102853:c4119038-4118688 [Escherichia coli]
ATGGTAAAGAAAAGTGAATTTGAACGGGGAGACATTGTGCTGGTTGGCTTTGATCCAGCAAGCGGCCATGAACAGCAAGG
TGCTGGTCGACCTGCGCTTGTGCTCTCCGTTCAAGCCTTTAATCAACTGGGAATGACGCTGGTGGCCCCCATTACGCAGG
GCGGAAATTTTGCCCGTTATGCCGGATTTAGCGTTCCTTTACATTGCGAAGAAGGCGATGTGCACGGCGTGGTGCTGGTG
AATCAGGTGCGGATGATGGATCTACGCGCCCGGCTGGCAAAGCGTATTGGTCTGGCTGCGGATGAGGTGGTGGAAGAGGC
GTTATTACGCTTGCAGGCGGTGGTGGAATAA

Antitoxin


Download         Length: 104 a.a.        Molecular weight: 11831.79 Da        Isoelectric Point: 10.2031

>AT207044 WP_115168368.1 NZ_CP077318:c95519-95208 [Providencia rettgeri]
MTKRDIFSELQEGMEAWSEFNEGKKTLKTHRINMKPLSMTPTEVKAIREKLKLSQAVFAQYLHTGVTTLQNWEQGLAKPN
KQAVLLLKMVEKRPDTLNELAGF

Download         Length: 312 bp

>AT207044 NZ_CP102853:c4119283-4119032 [Escherichia coli]
ATGCGTATTACCATAAAAAGATGGGGGAACAGTGCAGGTATGGTCATTCCCAATATCGTAATGAAAGAACTTAACTTACA
GCCGGGGCAGAGCGTGGAAGCGCAGGTGAGCAACAACCAACTGATTCTGACACCCATCTCCAGGCGCTACTCGCTTGATG
AACTGCTGGCACAGTGTGACATGAACGCCGCGGAACTTAGCGAGCAGGATGTCTGGGGTAAATCCACCCCTGCGGGTGAC
GAAATATGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References