Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/Tad-HTH_37
Location 72534..73137 Replicon plasmid unnamed1
Accession NZ_CP077304
Organism Acinetobacter pittii strain FDAARGOS 1396

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag I6L26_RS18320 Protein ID WP_000288004.1
Coordinates 72534..72863 (+) Length 110 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag I6L26_RS18325 Protein ID WP_001258993.1
Coordinates 72850..73137 (+) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
I6L26_RS18280 (I6L26_18280) 68336..68664 + 329 Protein_63 DUF4236 domain-containing protein -
I6L26_RS18285 (I6L26_18285) 68906..69418 - 513 WP_000464612.1 Fic family protein -
I6L26_RS18290 (I6L26_18290) 69421..69606 - 186 WP_000755724.1 hypothetical protein -
I6L26_RS18295 (I6L26_18295) 69773..70705 + 933 WP_000743263.1 IS5 family transposase -
I6L26_RS18300 (I6L26_18300) 70836..71033 - 198 WP_025464206.1 hypothetical protein -
I6L26_RS18305 (I6L26_18305) 71126..71344 - 219 WP_000994925.1 hypothetical protein -
I6L26_RS18310 (I6L26_18310) 71401..72003 - 603 WP_000096286.1 BRO family protein -
I6L26_RS18315 (I6L26_18315) 72210..72479 + 270 WP_000453245.1 transcriptional regulator -
I6L26_RS18320 (I6L26_18320) 72534..72863 + 330 WP_000288004.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
I6L26_RS18325 (I6L26_18325) 72850..73137 + 288 WP_001258993.1 helix-turn-helix transcriptional regulator Antitoxin
I6L26_RS18330 (I6L26_18330) 73174..73362 - 189 WP_000340067.1 hypothetical protein -
I6L26_RS18335 (I6L26_18335) 73757..74080 - 324 Protein_74 DUF4236 domain-containing protein -
I6L26_RS18340 (I6L26_18340) 74089..74265 - 177 WP_002120129.1 hypothetical protein -
I6L26_RS18345 (I6L26_18345) 74337..74660 - 324 WP_005804845.1 hypothetical protein -
I6L26_RS18350 (I6L26_18350) 75015..75524 - 510 Protein_77 terminase -
I6L26_RS18355 (I6L26_18355) 75508..76031 - 524 Protein_78 DUF2280 domain-containing protein -
I6L26_RS18360 (I6L26_18360) 76122..76763 - 642 WP_000372120.1 putative metallopeptidase -
I6L26_RS18365 (I6L26_18365) 76732..77193 - 462 WP_000378528.1 hypothetical protein -
I6L26_RS18370 (I6L26_18370) 77254..77709 - 456 WP_001136766.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..94386 94386
- flank IS/Tn - - 69773..70705 932


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(13-102)

Antitoxin

Cro/C1-type helix-turn-helix domain

(38-90)


Sequences

Toxin        


Download         Length: 110 a.a.        Molecular weight: 12571.69 Da        Isoelectric Point: 8.8102

>T207019 WP_000288004.1 NZ_CP077304:72534-72863 [Acinetobacter pittii]
MYTIEYYSEDVQDEILTLPDGLLARYFNLTDRMVIYGANLGEPHTLPMSKGLFELRLKSQEGIARVMYCTLVGKRIVMLH
SFVKKTQKTPKQDLNLALDRMKEVKNANT

Download         Length: 330 bp

>T207019 NZ_CP102850:c399257-399039 [Gordonia mangrovi]
ATCGATCCGCGGATTCACCGGGTCGCGCTGCGCAAACTTCGTCAGGTGGGATCGGCAGAGTCGCTCGACGACCTCACGGT
CCCACCCGGGAATCGGCTCGAAGCACTGAAAGGTGATCGGGCGGGACAACACAGCATCAGAATCAATGACCAGTGGCGAA
TCTGCTTCGTCTGGGCGGACACTGGGCCGGAGGAGGTCGAGATCGTTGACTACCACTGA

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10565.30 Da        Isoelectric Point: 10.1453

>AT207019 WP_001258993.1 NZ_CP077304:72850-73137 [Acinetobacter pittii]
MRTHEEMKALALSRSAVRTEYERIEREEMPLLDMVLTARRDAGLSQAQIAERMGTSVPAVSRLEKALITGKPSPSIATLQ
KYAAAIGKHVEVRFV

Download         Length: 288 bp

>AT207019 NZ_CP102850:c399052-398750 [Gordonia mangrovi]
TTGACTACCACTGACAAGATCGCGCCGATCCATCCCGGGGAAGTCCTCATGGAGGACTTCATCGAAGGTTTCGGCATCAC
GCAGAACAAGTTGGCGGTGTCAGTGGGTGTGCCTCCGCGGCGCATCAATGAGATCGTGCACGGCAAGCGCGCGATCAGCG
CTGACACGGCCTTGCGACTTGGGAAGTACTTTGGCACATCGGCTCAATTCTGGCTCAATCTGCAGTCGCATTACGACCTG
GACCTCGCCGAGGACCGTGCAGCAGAGCAGATTGCCGCGATCATTCCGCTTCAGTCGGCATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References