Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 39084..39735 Replicon plasmid unnamed1
Accession NZ_CP077304
Organism Acinetobacter pittii strain FDAARGOS 1396

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag I6L26_RS18180 Protein ID WP_000269910.1
Coordinates 39084..39392 (+) Length 103 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag I6L26_RS18185 Protein ID WP_001140619.1
Coordinates 39433..39735 (+) Length 101 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
I6L26_RS18715 34303..34392 + 90 Protein_36 DNA-binding protein -
I6L26_RS18150 (I6L26_18150) 34709..35227 + 519 WP_000447196.1 tetratricopeptide repeat protein -
I6L26_RS18155 (I6L26_18155) 35359..35871 + 513 WP_001089570.1 SMI1/KNR4 family protein -
I6L26_RS18160 (I6L26_18160) 36079..36981 + 903 WP_000466974.1 hypothetical protein -
I6L26_RS18165 (I6L26_18165) 37238..37483 + 246 WP_000246757.1 type II toxin-antitoxin system RelB/DinJ family antitoxin -
I6L26_RS18170 (I6L26_18170) 37473..37766 + 294 WP_000221360.1 type II toxin-antitoxin system RelE/ParE family toxin -
I6L26_RS18175 (I6L26_18175) 37953..38069 + 117 Protein_42 IS5/IS1182 family transposase -
I6L26_RS18180 (I6L26_18180) 39084..39392 + 309 WP_000269910.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
I6L26_RS18185 (I6L26_18185) 39433..39735 + 303 WP_001140619.1 XRE family transcriptional regulator Antitoxin
I6L26_RS18190 (I6L26_18190) 39728..39937 + 210 WP_000069470.1 hypothetical protein -
I6L26_RS18195 (I6L26_18195) 40047..40274 - 228 WP_000555567.1 hypothetical protein -
I6L26_RS18200 (I6L26_18200) 41040..41343 - 304 Protein_47 XRE family transcriptional regulator -
I6L26_RS18205 (I6L26_18205) 41336..41692 - 357 WP_000269908.1 type II toxin-antitoxin system RelE/ParE family toxin -
I6L26_RS18210 (I6L26_18210) 42250..42933 + 684 WP_000478902.1 hypothetical protein -
I6L26_RS18215 (I6L26_18215) 43138..43666 + 529 Protein_50 IS3 family transposase -
I6L26_RS18220 (I6L26_18220) 43909..44229 + 321 WP_001081101.1 type II toxin-antitoxin system Phd/YefM family antitoxin -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..94386 94386


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(12-102)

Antitoxin

HigA2-like, helix-turn-helix domain

(13-89)


Sequences

Toxin        


Download         Length: 103 a.a.        Molecular weight: 11742.64 Da        Isoelectric Point: 9.0002

>T207018 WP_000269910.1 NZ_CP077304:39084-39392 [Acinetobacter pittii]
MWTVITTDLFNEWLVQQDQSTQEKVLAALVVLQQQGPSLGRPLVDTVYDSKFTNMKELRVQHRGKPLRAFFAFDPLRQAI
VLCIGDKGGKKRFYKEMLDIAD

Download         Length: 309 bp

>T207018 NZ_CP102843:c11046-10732 [Klebsiella pneumoniae]
ATGCCACAGGTAACGATTTCCGCGCTGGCACAGCGAGATTTACAACGCCTCCAGGACTTTCTCAAAACCAAAAATCGGCT
GGCAGCCAGAAAAGCCGGTGAGGTGATCGTCCGGGCTATCCAGCAACTGAAAACATTGCCAGACATTGGCCGCCCGGTGC
CATTTCTGCCGCTGGAATATCAGGAACTGGTGATCGGGTTTGGCGACAGTGGCTATGTGATGCTCTACCGCCACGACCGG
GAAATGGACCGGATTGTGATCGTCACCGTCAGGCATCAGAAAGAATCCGGGTATCCGGGGGCAGACAGCCTCTAA

Antitoxin


Download         Length: 101 a.a.        Molecular weight: 11206.01 Da        Isoelectric Point: 6.7282

>AT207018 WP_001140619.1 NZ_CP077304:39433-39735 [Acinetobacter pittii]
MAKTLQELLANRSPESQARIQQMADELLLETQLHLIREELEISQKELAATLGIKQPSLSAIENRGHDLKISTMKKYVEAM
GGKLRIDVELPTGKHIGFNV

Download         Length: 303 bp

>AT207018 NZ_CP102843:c11312-11034 [Klebsiella pneumoniae]
ATGTCATCAGCAACATCCATCAGGCTCGATGAAGAACTTAAGGACCGGCTGAAAACGCTGGCCGATGACCGGCACCGCTC
AGCGCACGCGCTAATGCTGGAGGCAATCACCGAATACATCGACCGGGAAGAGAAGCGCAGCCAGTACCTGCGGGACGGAC
AAGCCGCATGGCAGCACTATCAGGAAACGGGTCTGCACCTTACTGCGGAAGAAGCAGAAGCCTGGATAAGTACCTGGGGA
ACTGAGAACGAGCAGGATGCTCCGCCATGCCACAGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References