207014

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-RelB
Location 2315414..2315931 Replicon chromosome
Accession NZ_CP077302
Organism Corynebacterium coyleae strain FDAARGOS 1425

Toxin (Protein)


Gene name yoeB Uniprot ID A0A1H4NRG6
Locus tag I6L55_RS11165 Protein ID WP_070423172.1
Coordinates 2315671..2315931 (+) Length 87 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID A0A1H4NQ62
Locus tag I6L55_RS11160 Protein ID WP_070423251.1
Coordinates 2315414..2315674 (+) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
I6L55_RS11140 (I6L55_11140) 2310879..2312183 + 1305 WP_092102541.1 hypothetical protein -
I6L55_RS11145 (I6L55_11145) 2312495..2312881 + 387 WP_143028479.1 hypothetical protein -
I6L55_RS11150 (I6L55_11150) 2313044..2313919 - 876 WP_092102547.1 pyridoxal 5'-phosphate synthase lyase subunit PdxS -
I6L55_RS11155 (I6L55_11155) 2313978..2315336 + 1359 WP_244268726.1 PLP-dependent aminotransferase family protein -
I6L55_RS11160 (I6L55_11160) 2315414..2315674 + 261 WP_070423251.1 type II toxin-antitoxin system prevent-host-death family antitoxin Antitoxin
I6L55_RS11165 (I6L55_11165) 2315671..2315931 + 261 WP_070423172.1 Txe/YoeB family addiction module toxin Toxin
I6L55_RS11170 (I6L55_11170) 2315941..2317464 - 1524 WP_092102553.1 proteasome ATPase -
I6L55_RS11175 (I6L55_11175) 2317503..2318336 - 834 WP_070423170.1 tRNA (adenine-N1)-methyltransferase -
I6L55_RS11180 (I6L55_11180) 2318352..2319563 - 1212 WP_092102555.1 M18 family aminopeptidase -
I6L55_RS11185 (I6L55_11185) 2319590..2320429 + 840 WP_092103091.1 RecB family exonuclease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(1-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-72)


Sequences

Toxin        


Download         Length: 87 a.a.        Molecular weight: 10381.82 Da        Isoelectric Point: 8.0396

>T207014 WP_070423172.1 NZ_CP077302:2315671-2315931 [Corynebacterium coyleae]
MILSWDEDAWAEYVEWQTTDKRVLKRINMLIRDIQRNGNQGIGKPEPLKHELSGYWSRRITSEHRLVYKMTETEIRIAAC
RYHYGE

Download         Length: 261 bp

>T207014 NZ_CP102841:c5206656-5206273 [Klebsiella pneumoniae]
ATGACCTCCGGATCTGCGCTTTTTGATACCAATATTCTTATTGATTTATTTAGCGGGCGTCGCGAAGCCAAACAGGCGCT
GGAGGCCTGGCCACCGCAGAATGCGATCAGTCTGATTACCTGGATGGAGGTGATGGTTGGCGCTAAAAAATATCACCAGG
AGCAGCGCACGCGAATGGCGCTGAGCACCTTTAATATCATTAACATCTCACAGGATATTGCAGAGCGAAGCGTTGCGCTG
CGGCAGGAGTATAAGCTTAAGCTGCCGGATGCCATCATTCTGGCGACGGCGCAACTCCATCGTCTGGAACTAATTACGCG
GAATACGAAGGATTTTGCCGGTATTCCTGGCGTAGTCACGCCGTACGAAATCCACCCTGAATAA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9793.00 Da        Isoelectric Point: 4.3356

>AT207014 WP_070423251.1 NZ_CP077302:2315414-2315674 [Corynebacterium coyleae]
MKVMSYSESRANYAEVLNTVVDDCEEVVITRSGHDPVVIVSLAEYESMKETSYLLQSPANARVLKERIERLEKGTSVQNE
LIEEDR

Download         Length: 261 bp

>AT207014 NZ_CP102841:c5206898-5206656 [Klebsiella pneumoniae]
ATGATGGCTGAAAGGGATATGGGCAGAATTCTTCTCGATTTATCAGACGATGTCATTCAACGTCTCGATGACCTCAAAGT
GCAGCGTAACATTCCGCGAGCGGAACTGTTACGTGAAGCGGTTGAACAATATCTGGAGAAACAAGATCGAGCTAAAGATA
CCATCTCCAGTGCGCTGGGTCTGTGGCAAGACTGCGAAGAAGACGGCATGGAATATCAACGTCAGCTACGCAAGGAGTGG
TAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1H4NRG6

Antitoxin

Source ID Structure
AlphaFold DB A0A1H4NQ62

References