Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 1934506..1935082 Replicon chromosome
Accession NZ_CP077302
Organism Corynebacterium coyleae strain FDAARGOS 1425

Toxin (Protein)


Gene name graT Uniprot ID -
Locus tag I6L55_RS09380 Protein ID WP_092102065.1
Coordinates 1934506..1934787 (+) Length 94 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID A0A1F1URP9
Locus tag I6L55_RS09385 Protein ID WP_070452758.1
Coordinates 1934822..1935082 (+) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
I6L55_RS09350 (I6L55_09350) 1930729..1930998 - 270 WP_005293257.1 hypothetical protein -
I6L55_RS09355 (I6L55_09355) 1931191..1931541 - 351 WP_038593990.1 hypothetical protein -
I6L55_RS09360 (I6L55_09360) 1931538..1932959 - 1422 WP_070484394.1 mercury(II) reductase -
I6L55_RS09365 (I6L55_09365) 1933058..1933447 + 390 WP_005290994.1 heavy metal-responsive transcriptional regulator -
I6L55_RS09370 (I6L55_09370) 1933491..1933619 - 129 WP_005293248.1 monooxygenase -
I6L55_RS09375 (I6L55_09375) 1933822..1934172 - 351 WP_070452620.1 VOC family protein -
I6L55_RS09380 (I6L55_09380) 1934506..1934787 + 282 WP_092102065.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
I6L55_RS09385 (I6L55_09385) 1934822..1935082 + 261 WP_070452758.1 HigA family addiction module antitoxin Antitoxin
I6L55_RS09390 (I6L55_09390) 1935096..1935686 - 591 WP_083284865.1 putative glycolipid-binding domain-containing protein -
I6L55_RS09395 (I6L55_09395) 1935735..1936178 - 444 WP_070452622.1 alternative ribosome rescue aminoacyl-tRNA hydrolase ArfB -
I6L55_RS09400 (I6L55_09400) 1936200..1936487 - 288 WP_070452625.1 type II toxin-antitoxin system RelE/ParE family toxin -
I6L55_RS09405 (I6L55_09405) 1936497..1936712 - 216 WP_070452628.1 DUF6290 family protein -
I6L55_RS09410 (I6L55_09410) 1937079..1938116 - 1038 WP_092102067.1 FUSC family protein -
I6L55_RS09415 (I6L55_09415) 1938254..1938700 + 447 WP_092102070.1 aminoglycoside N-acetyltransferase AAC(3)-XI -
I6L55_RS09420 (I6L55_09420) 1938697..1939728 - 1032 WP_070568648.1 HAMP domain-containing sensor histidine kinase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(1-93)

Antitoxin

Toxin-antitoxin system, antidote protein, HigA

(2-69)


Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 11024.51 Da        Isoelectric Point: 9.8469

>T207013 WP_092102065.1 NZ_CP077302:1934506-1934787 [Corynebacterium coyleae]
MIQSFADKDTERLWNRERVRSIDSRIHSVALRKLRQLGYAQTLDELRIPPGSRLEALKGDRRGQFSIRINDQWRICFRWS
AAGPEEVEIVDYH

Download         Length: 282 bp

>T207013 NZ_CP102841:c4883114-4882239 [Klebsiella pneumoniae]
ATGCAGGTTTTACCCTATGTTGCTGTCGAACGGGAATTTGCGCTGAAAGGTGGCACTGCCATCAATCTCTTTATCCGCGA
TTTCCCTCGATTATCGGTGGATATCGACCTCGCCTGGGTGCCCCTGGAAAGCAGAGCCATCGCTTTACCTCATATACGGG
ATGCGCTTGCACGTATTGCCGCCAATCTGCAACAACAGGCAGGTATGAGCGCTGTATTACAAGCTAATCGTTCAGATGAG
ATGCGTGTCATTGTTACTACCGATAGCGCGCAAATAAAGATAGAGGTTTCACCGGTCGCCCGGGGAACATTATATCCACC
ACAGGAGCGAGAAGTGGTGGGGGCGGTAGAGGACGTTTTTGGCTATGCCAGCCTTCCAGTGGTTTCGTTGCCTGACCTCT
ACGGTGGAAAATTATGCGCGGCGCTGGATCGCCAGCATCCCAGAGATTTTTATGACGTGAAATTACTTCTTGATGCGCAG
GAGCTTGACCGTCCCATTTTCAATGGGTTTATCGTGTATTTACTGAGCCATAATCGGCCTCTGGCTGAAGTGCTGAATCC
TCGCTGGAAAGATATTGCTGAACCTTTTTACCGTGAATTCAGCGGGATGACATTTGAGACGATAGCCCTGGAGGAACTGA
CAGCAGTCCCCAACAGGATGATTGCTGCGTTAAAATCCTGTATCACACAACAGGATGTCGATTTTTTACTGTCATTTAAA
CGAGGCGAACCAGACTGGCGTTTAGCGCCGGAAATGCGTATTCAGGATTTGCCTGCCGTGCAGTGGAAATTGCGCAATAT
TCATCAGATGCCAGCGATAAAACGCGCTGAGTCATTAGATAAACTGGAAAAGGTGCTGGCCGAGTGGCGCAGTTAG

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9677.22 Da        Isoelectric Point: 5.6726

>AT207013 WP_070452758.1 NZ_CP077302:1934822-1935082 [Corynebacterium coyleae]
MEDFLKEMEITQHKLAVSIGVPPRRINEIVHGKRAVTADTALRLAKFFGMSPQFWLGLQAQYDLDVAEDKILAEIERIQP
LQAASA

Download         Length: 261 bp

>AT207013 NZ_CP102841:c4883920-4883162 [Klebsiella pneumoniae]
ATGGCAACAAAATTAAACTGGCTGCTGCAAAACAGCGCTCCCGGAGATGTGATCCTTCAGTCCTGGTTAAGCCAGCATGC
CATCTCTCCCTCTCTGGCCTTTAAATACGCGCAAAGTGGCTGGTTAAAAAAAAGAGGCAACGGCGTATATGCGCGTGCGG
GACGTGAGCCGGAGTGGAACGATGCATTAGCATGTTTGCAAAATCAGCTTGCCGCTCCGGTGTATGTTGCGGGGCTCAGT
AGCTTAGTCTGGCAGGGCCGTTCACACTATCTACAGCTAAAACAAAACCAGTGCTGGCTTAGTGTGGAAAATAAAGCGCT
GCTGCCGAAATGGTTCAGGGAATTCCCGGGTGTGGAGTGGATAGTCATATCGGGGAAAAAACTGCCGGTGCTGGATGATA
GATACCGTGTAACGCTTGATATAAAAGGGAAAAAACTCATCGGCAGTGCGCCAGAACTGGCTGCTTACGAGTTGCTGAGC
GCGGTGCCGGGGACCCTCTCATTTAACCACGCTGCAGAGCTTTTCCAGGGGCTGGTTAATCTTAATCCTCGTAAAGTAGA
GTATCTTCTTTCCGTCAGCCAGTCCGTGCAGGCCAAGCGTTTGTATCTCTTCTTCGCCAGTTTTTACGAGCATGGCTGGC
TCAAACGAATCGATAGCCAAAAAATCGATCTGGGAGCGGGCAAGCGGCAAATCGTGGAAAATGGAAAGTTCAATGCTCAA
TACCAAATCACAGTGCCTGAACGCTTTCAAAAGGAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A1F1URP9

References