Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 4156449..4157176 Replicon chromosome
Accession NZ_CP077291
Organism Citrobacter farmeri strain FDAARGOS 1423

Toxin (Protein)


Gene name higB Uniprot ID A0A8H9NTD6
Locus tag I6L53_RS19520 Protein ID WP_042325266.1
Coordinates 4156862..4157176 (-) Length 105 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag I6L53_RS19515 Protein ID WP_042325268.1
Coordinates 4156449..4156865 (-) Length 139 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
I6L53_RS19500 (I6L53_19500) 4151781..4153169 + 1389 WP_042325274.1 phosphomannomutase/phosphoglucomutase -
I6L53_RS19505 (I6L53_19505) 4153166..4154236 + 1071 WP_042325272.1 sn-glycerol-3-phosphate ABC transporter ATP-binding protein UgpC -
I6L53_RS19510 (I6L53_19510) 4154374..4156392 + 2019 WP_042325270.1 NADPH-dependent 2,4-dienoyl-CoA reductase -
I6L53_RS19515 (I6L53_19515) 4156449..4156865 - 417 WP_042325268.1 helix-turn-helix domain-containing protein Antitoxin
I6L53_RS19520 (I6L53_19520) 4156862..4157176 - 315 WP_042325266.1 type II toxin-antitoxin system HigB family toxin Toxin
I6L53_RS19525 (I6L53_19525) 4157392..4158528 - 1137 WP_042325264.1 23S rRNA (guanine(1835)-N(2))-methyltransferase RlmG -
I6L53_RS19530 (I6L53_19530) 4158615..4159118 + 504 WP_042325262.1 M48 family metallopeptidase -
I6L53_RS19535 (I6L53_19535) 4159188..4160186 + 999 WP_042325259.1 Gfo/Idh/MocA family oxidoreductase -
I6L53_RS19540 (I6L53_19540) 4160457..4161422 + 966 WP_042325257.1 TerC family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, mRNA interferase HigB

(22-93)

Antitoxin

Cro/C1-type helix-turn-helix domain

(82-136)


Sequences

Toxin        


Download         Length: 105 a.a.        Molecular weight: 11977.13 Da        Isoelectric Point: 10.4647

>T206977 WP_042325266.1 NZ_CP077291:c4157176-4156862 [Citrobacter farmeri]
MHLITLKALRDAAEKYPQHTPELIALGNVLSKGCFRTPAALKAVFPSLDNFKYLDKHYVINIGRNALRVVVLLFFTSQKC
YIRHVFTHKEYDAFTAMHRTKGKK

Download         Length: 315 bp

>T206977 NZ_CP102833:1969816-1969918 [Klebsiella pneumoniae]
GCAAGGCGACTTAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATACA
GGAATCGTATTCGGTCTCTTTTT

Antitoxin


Download         Length: 139 a.a.        Molecular weight: 15171.76 Da        Isoelectric Point: 4.9093

>AT206977 WP_042325268.1 NZ_CP077291:c4156865-4156449 [Citrobacter farmeri]
MMVISEILKAGEKLTAVAPFLAGIHNEEQYADAMLFIDHLLLNDPDNPLLDLVCAKITAWEKSAPEFAEFNALLETMPAG
VSIIRVLMDQHGLNMTDLPEIGSKSMVSRVLNGQRKLTLEHAKKLAARFGISPALFID

Download         Length: 417 bp

>AT206977 NZ_CP102833:c1969925-1969780 [Klebsiella pneumoniae]
TAAAGATAAAAAGAGACCGAATACGATTCCTGTATTCGGTCCAGGGAAATGGCTCTTGGGAGAGAGCCGTGCGCTAAAAG
TTGGCATTAATGCAGGCTAAGTCGCCTTGCACTATAAGAATAGTTTAACGCGTCAGCTTTTCCAGT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References