Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 2329848..2330410 Replicon chromosome
Accession NZ_CP077291
Organism Citrobacter farmeri strain FDAARGOS 1423

Toxin (Protein)


Gene name higB Uniprot ID A0A8H9P083
Locus tag I6L53_RS10955 Protein ID WP_042319014.1
Coordinates 2330132..2330410 (-) Length 93 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag I6L53_RS10950 Protein ID WP_042319013.1
Coordinates 2329848..2330132 (-) Length 95 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
I6L53_RS10930 (I6L53_10930) 2324984..2328031 + 3048 WP_094465436.1 formate dehydrogenase-N subunit alpha -
I6L53_RS10935 (I6L53_10935) 2328044..2328928 + 885 WP_042319010.1 formate dehydrogenase subunit beta -
I6L53_RS10940 (I6L53_10940) 2328921..2329577 + 657 WP_042319012.1 formate dehydrogenase-N subunit gamma -
I6L53_RS10945 (I6L53_10945) 2329689..2329781 + 93 Protein_2128 inorganic diphosphatase -
I6L53_RS10950 (I6L53_10950) 2329848..2330132 - 285 WP_042319013.1 HigA family addiction module antitoxin Antitoxin
I6L53_RS10955 (I6L53_10955) 2330132..2330410 - 279 WP_042319014.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
I6L53_RS10960 (I6L53_10960) 2330590..2332305 - 1716 WP_042319015.1 ABC-F family ATP-binding cassette domain-containing protein -
I6L53_RS10965 (I6L53_10965) 2332614..2334311 - 1698 WP_042319016.1 malate dehydrogenase -
I6L53_RS10970 (I6L53_10970) 2334483..2334626 - 144 WP_042319017.1 stationary-phase-induced ribosome-associated protein -
I6L53_RS10975 (I6L53_10975) 2334854..2335285 + 432 WP_042319018.1 peroxiredoxin OsmC -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(1-92)

Antitoxin

Toxin-antitoxin system, antidote protein, HigA

(1-83)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10585.13 Da        Isoelectric Point: 8.9570

>T206972 WP_042319014.1 NZ_CP077291:c2330410-2330132 [Citrobacter farmeri]
MIMNFRHKGLRDLFLHGKTSGVMAKHVRRLRHRLAVIDAAGCVNDINMPGYRLHPLSGDRDGVWAISVSGNWRLTFEFVN
GDAYILDYEDYH

Download         Length: 279 bp

>T206972 NZ_CP102832:c21462-21106 [Acinetobacter baumannii]
ATGTGGACAGTCATTACAACGGATCTGTTTAATGAATGGCTTGAACAGCAAGATGAAGCAACACAAGAGAAAGTCTTAGC
TGCATTGGTTGTTCTACAACAGCAAGGGCCTAGTTTAGGTCGTCCTTTAGTAGATACCGTCTACGATTCTAAATTTACCA
ATATGAAGGAACTACGTGTTCAGCATCGTGGTAAACCGTTAAGGGCATTTTTTGCATTCGATCCCCTAAGACAAGCGATT
GTGCTGTGTATTGGTGATAAGAGTAATAAAAAGCGTTTTTATACAGAGATGCTAGCAATTGCAGATGAGCAATACGCACT
TCATCTCTCAACTTTAGGAGATCAATCTAATGGCTAA

Antitoxin


Download         Length: 95 a.a.        Molecular weight: 10371.06 Da        Isoelectric Point: 8.8567

>AT206972 WP_042319013.1 NZ_CP077291:c2330132-2329848 [Citrobacter farmeri]
MKMANHPRPGDIIQEALDELNVSLREFARAMEIAPSTASRLLTGKAALTPEMAIKLSVVIGSSPEMWLNLQNTWSLAEAQ
KSVDVSRLRRLAVQ

Download         Length: 285 bp

>AT206972 NZ_CP102832:c21113-20811 [Acinetobacter baumannii]
ATGGCTAAGAGCTTACAAGAATTATTGGCTAGTCGCTCTCCAGAGAGTCAAGCTCGTATTCAAAAAATGGCTGATGAATT
ACTTTTAGAAAGTCAGCTTCACCTTATCCGAGAAGAGTTAGAAATTTCCCAGAAAGAACTAGCTGCAACCCTTGGAATTA
AACAGCCGTCATTATCAGCAATCGAAAATCGTGGTCATGATCTTAAAATTTCAACGATGAAAAAGTATGTTGAAGCAATG
GGTGGAAAACTTCGTATTGATGTAGAGCTTCCAACAGGAAAACACATAGGGTTCAATGTCTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References