Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 1051701..1052390 Replicon chromosome
Accession NZ_CP077265
Organism Klebsiella aerogenes strain FDAARGOS 1441

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag I6L71_RS04940 Protein ID WP_032711783.1
Coordinates 1052094..1052390 (-) Length 99 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag I6L71_RS04935 Protein ID WP_032711784.1
Coordinates 1051701..1052036 (-) Length 112 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
I6L71_RS04910 (I6L71_04910) 1046901..1047344 - 444 WP_015705626.1 GNAT family N-acetyltransferase -
I6L71_RS04915 (I6L71_04915) 1047525..1048508 + 984 WP_015366313.1 zinc transporter ZntB -
I6L71_RS04920 (I6L71_04920) 1048993..1050366 + 1374 WP_048229293.1 ATP-dependent RNA helicase DbpA -
I6L71_RS04925 (I6L71_04925) 1050414..1051349 - 936 WP_032711785.1 tRNA 2-thiocytidine(32) synthetase TtcA -
I6L71_RS04930 (I6L71_04930) 1051397..1051666 - 270 Protein_966 tyrosine-type recombinase/integrase -
I6L71_RS04935 (I6L71_04935) 1051701..1052036 - 336 WP_032711784.1 HigA family addiction module antitoxin Antitoxin
I6L71_RS04940 (I6L71_04940) 1052094..1052390 - 297 WP_032711783.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
I6L71_RS04945 (I6L71_04945) 1052627..1053061 - 435 WP_015366316.1 universal stress protein UspF -
I6L71_RS04950 (I6L71_04950) 1053206..1054348 - 1143 WP_048228811.1 porin OmpC -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(5-98)

Antitoxin

Toxin-antitoxin system, antidote protein, HigA

(6-84)


Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 11555.10 Da        Isoelectric Point: 6.6433

>T206917 WP_032711783.1 NZ_CP077265:c1052390-1052094 [Klebsiella aerogenes]
MQNHIGSFRDVWLEEFFLHSAPHEKIPPDIHTTLARKLDIINAAVTYLDLRSPPGNRYEELNGKLEGYSSIRINQQYRLI
FKWVDGKAEDLYLDPHKY

Download         Length: 297 bp

>T206917 NZ_CP102756:c1480433-1480215 [Salmonella enterica subsp. enterica serovar Kentucky]
ATGTCTGATAAACCATTAACTAAAACTGATTATTTGATGCGTTTACGGCGCTGTCAGACAATTGACACTCTGGAGCGCGT
CATTGAGAAAAATAAATATGAATTGTCCGACAATGAGCTGGCTGTATTTTACTCAGCTGCGGATCACCGTCTTGCAGAAT
TGACGATGAACAAACTCTACGACAAGATCCCCTCTTCAGTATGGAAATTCATTCGTTAA

Antitoxin


Download         Length: 112 a.a.        Molecular weight: 12694.53 Da        Isoelectric Point: 7.2045

>AT206917 WP_032711784.1 NZ_CP077265:c1052036-1051701 [Klebsiella aerogenes]
MKQATRKPTTVGDILQFEYLEPLDLKINELAEMIHVHRNSVSALVNNNRKLTTDMAFRLSKAFNTTVDFWLNLQAAVDLW
EVENDTRAQEEFSRIVPASKFIASKADKKVA

Download         Length: 336 bp

>AT206917 NZ_CP102756:c1480835-1480461 [Salmonella enterica subsp. enterica serovar Kentucky]
ATGGACGAATACTCACCCAAAAGACATGATATAGCACAGCTTAAATTTCTTTGCGAAACCCTGTATCATGACTGTCTTGC
AAACCTTGAAGAAAGCAACCATGGCTGGGTTAATGACCCGACCTCAGCAGTCAACCTGCAGCTCAATGAGCTGATAGAGC
ATATTGCAACTTTCGCGCTTAATTATAAAATTAAGTACAATGAAGACAATAAATTGATTGCGCAGATAGATGAATACCTG
GACGACACCTTTATGTTGTTCAGCAGCTATGGTATTAATACGCAGGATTTGCAAAAATGGCGTAAATCGGGCAACCGCCT
GTTCCGTTGTTTCGTCAACGCCACCAGGGCTAATCCTGTTAGTTTGTCTTGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References